| UniProt ID | RFOX1_HUMAN | |
|---|---|---|
| UniProt AC | Q9NWB1 | |
| Protein Name | RNA binding protein fox-1 homolog 1 | |
| Gene Name | RBFOX1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 397 | |
| Subcellular Localization | Nucleus. Cytoplasm. | |
| Protein Description | RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.. | |
| Protein Sequence | MNCEREQLRGNQEAAAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPEHTLNLYPPAQTHSEQSPADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTENKSQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKTVNPYTNGWKLNPVVGAVYSPEFYAGTVLLCQANQEGSSMYSAPSSLVYTSAMPGFPYPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVYQDGFYGADIYGGYAAYRYAQPTPATAAAYSDSYGRVYAADPYHHALAPAPTYGVGAMNAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYNRFAPY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 62 | Phosphorylation | QTTVPEHTLNLYPPA CCCCCCCCEECCCCC | 18.71 | 24275569 | |
| 66 | Phosphorylation | PEHTLNLYPPAQTHS CCCCEECCCCCCCCC | 13.19 | 24275569 | |
| 71 | Phosphorylation | NLYPPAQTHSEQSPA ECCCCCCCCCCCCCC | 29.49 | 24275569 | |
| 84 | Phosphorylation | PADTSAQTVSGTATQ CCCCCCCEECCEEEE | 19.16 | 24275569 | |
| 134 | Methylation | RFRDPDLRQMFGQFG CCCCHHHHHHHHHHC | 33.04 | - | |
| 156 | Ubiquitination | IFNERGSKGFGFVTF EEECCCCCCEEEEEE | 62.17 | - | |
| 161 (in isoform 1) | Ubiquitination | - | 6.49 | 21890473 | |
| 161 (in isoform 3) | Ubiquitination | - | 6.49 | 21890473 | |
| 175 | Ubiquitination | DADRAREKLHGTVVE CHHHHHHHHCCEEEE | 39.98 | - | |
| 175 | Acetylation | DADRAREKLHGTVVE CHHHHHHHHCCEEEE | 39.98 | 19817473 | |
| 176 (in isoform 2) | Ubiquitination | - | 3.74 | 21890473 | |
| 176 (in isoform 4) | Ubiquitination | - | 3.74 | 21890473 | |
| 176 (in isoform 5) | Ubiquitination | - | 3.74 | 21890473 | |
| 179 | Phosphorylation | AREKLHGTVVEGRKI HHHHHCCEEEECCEE | 15.61 | 23532336 | |
| 185 | Ubiquitination | GTVVEGRKIEVNNAT CEEEECCEEEECCCE | 54.82 | - | |
| 205 | Phosphorylation | NKKTVNPYTNGWKLN CCCCCCCCCCCCCCC | 13.97 | 7102709 | |
| 317 | Asymmetric dimethylarginine | YGGYAAYRYAQPTPA ECCEEEEECCCCCCC | 18.65 | - | |
| 317 | Methylation | YGGYAAYRYAQPTPA ECCEEEEECCCCCCC | 18.65 | - | |
| 388 | Methylation | SLQASIYRGGYNRFA HHHHHHHCCCCCCCC | 30.32 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RFOX1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RFOX1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RFOX1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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