CRX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRX_HUMAN
• UniProt AC: O43186
• Protein Name: Cone-rod homeobox protein
• Gene Name: CRX
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors..
• Protein Sequence: MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MMAYMNPGPHY ----CCCCCCCCCCC	4.59	24043423
11	Phosphorylation	YMNPGPHYSVNALAL CCCCCCCCCCEEHHH	19.90	24043423
12	Phosphorylation	MNPGPHYSVNALALS CCCCCCCCCEEHHHC	13.08	24043423
19	Phosphorylation	SVNALALSGPSVDLM CCEEHHHCCCCCCHH	42.95	24043423
22	Phosphorylation	ALALSGPSVDLMHQA EHHHCCCCCCHHHHC	31.61	24043423
32	Phosphorylation	LMHQAVPYPSAPRKQ HHHHCCCCCCCCHHH	11.83	24043423
34	Phosphorylation	HQAVPYPSAPRKQRR HHCCCCCCCCHHHHH	45.09	24043423
61	Phosphorylation	LEALFAKTQYPDVYA HHHHHHHCCCCCCCC	29.88	24043423
63	Phosphorylation	ALFAKTQYPDVYARE HHHHHCCCCCCCCCC	13.46	22817900
67	Phosphorylation	KTQYPDVYAREEVAL HCCCCCCCCCCEEEH	13.81	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M1AP_HUMAN	M1AP	physical	16189514
MDFI_HUMAN	MDFI	physical	16189514
IPO13_HUMAN	IPO13	physical	15143176
ATX7_HUMAN	ATXN7	physical	11580893
KAT2A_HUMAN	KAT2A	physical	15932940
SP4_HUMAN	SP4	physical	15781457
SP1_HUMAN	SP1	physical	15781457
SP3_HUMAN	SP3	physical	15781457
BAF_HUMAN	BANF1	physical	12215455
KPCI_HUMAN	PRKCI	physical	23718855
IF5A1_HUMAN	EIF5A	physical	25416956
AF17_HUMAN	MLLT6	physical	25416956
ROR2_HUMAN	ROR2	physical	25416956
AAKB2_HUMAN	PRKAB2	physical	25416956
PSB10_HUMAN	PSMB10	physical	25416956
SOX5_HUMAN	SOX5	physical	25416956
STK16_HUMAN	STK16	physical	25416956
ATG12_HUMAN	ATG12	physical	25416956
GCM2_HUMAN	GCM2	physical	25416956
DELE_HUMAN	KIAA0141	physical	25416956
SFI1_HUMAN	SFI1	physical	25416956
ABI2_HUMAN	ABI2	physical	25416956
SZT2_HUMAN	SZT2	physical	25416956
PP16B_HUMAN	PPP1R16B	physical	25416956
OSGI1_HUMAN	OSGIN1	physical	25416956
NIP7_HUMAN	NIP7	physical	25416956
QRIC1_HUMAN	QRICH1	physical	25416956
CA109_HUMAN	C1orf109	physical	25416956
PCLI1_HUMAN	PID1	physical	25416956
GUCD1_HUMAN	GUCD1	physical	25416956
LONF1_HUMAN	LONRF1	physical	25416956
LARP4_HUMAN	LARP4	physical	25416956
KLH32_HUMAN	KLHL32	physical	25416956
UBX2B_HUMAN	UBXN2B	physical	25416956
CI072_HUMAN	C9orf72	physical	25416956
NRL_HUMAN	NRL	physical	25703721
NR2E3_HUMAN	NR2E3	physical	25703721

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613829: Leber congenital amaurosis 7 (LCA7)
• 120970: Cone-rod dystrophy 2 (CORD2)
• 268000: Retinitis pigmentosa (RP)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.