KLH32_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH32_HUMAN
• UniProt AC: Q96NJ5
• Protein Name: Kelch-like protein 32
• Gene Name: KLHL32
• Organism: Homo sapiens (Human).
• Sequence Length: 620
• Protein Sequence: MPSERCLSIQEMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIGTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
282	Phosphorylation	PVWQTRRTKPRFQSD CCCCCCCCCCCCCCC	41.95	29083192
288	Phosphorylation	RTKPRFQSDTLYIIG CCCCCCCCCCEEEEC	29.83	29083192
290	Phosphorylation	KPRFQSDTLYIIGGK CCCCCCCCEEEECCC	27.06	29083192
292	Phosphorylation	RFQSDTLYIIGGKKR CCCCCCEEEECCCCC	7.81	29083192
349	Ubiquitination	AVMGDFLFVAGGEVE EEECCEEEEECCEEE	3.41	-
385	Ubiquitination	WAEIAPMKNCREHFV HHHCCCCCCHHHHHH	52.41	-
399	Phosphorylation	VLGAMEEYLYAVGGR HHHHHHHHHHHCCCH	7.54	-
401	Phosphorylation	GAMEEYLYAVGGRNE HHHHHHHHHCCCHHH	9.80	-
476	Phosphorylation	PNQNKWISRSPMLQR CCCCCCCCCCHHHHH	26.12	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH32_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH32_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH32_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CDK4_HUMAN	CDK4	physical	23718855

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.