GUCD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GUCD1_HUMAN
• UniProt AC: Q96NT3
• Protein Name: Protein GUCD1
• Gene Name: GUCD1
• Organism: Homo sapiens (Human).
• Sequence Length: 240
• Protein Sequence: MRTEAEAAGPPLEPGDFVQLPVPVIQQLYHWDCGLACSRMVLRYLGQLDDSEFERALQKLQLTRSIWTIDLAYLMHHFGVRHRFCTQTLGVDKGYKNQSFYRKHFDTEETRVNQLFAQAKACKVLVEKCTVSVKDIQAHLAQGHVAIVLVNSGVLHCDLCSSPVKYCCFTPSGHHCFCRTPDYQGHFIVLRGYNRATGCIFYNNPAYADPGMCSTSISNFEEARTSYGTDEDILFVYLDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23 (in isoform 3)	Phosphorylation	-		20068231
24 (in isoform 3)	Phosphorylation	-		20068231
28 (in isoform 3)	Phosphorylation	-		20068231
51	Phosphorylation	YLGQLDDSEFERALQ HHCCCCHHHHHHHHH		-
59	Ubiquitination	EFERALQKLQLTRSI HHHHHHHHHHHHHHH		-
73	Phosphorylation	IWTIDLAYLMHHFGV HHHHHHHHHHHHHCC		-
93	Ubiquitination	TQTLGVDKGYKNQSF CCCCCCCCCCCCHHH		-
96	Ubiquitination	LGVDKGYKNQSFYRK CCCCCCCCCHHHHHH		-
103	Ubiquitination	KNQSFYRKHFDTEET CCHHHHHHCCCCHHH		-
115	Ubiquitination	EETRVNQLFAQAKAC HHHHHHHHHHHHHHH		-
120	Ubiquitination	NQLFAQAKACKVLVE HHHHHHHHHHHHHHH		-
123	Ubiquitination	FAQAKACKVLVEKCT HHHHHHHHHHHHHCE		-
128	Ubiquitination	ACKVLVEKCTVSVKD HHHHHHHHCEEEHHH		-
149	Ubiquitination	QGHVAIVLVNSGVLH CCCEEEEEECCCCCC		-
152	Ubiquitination	VAIVLVNSGVLHCDL EEEEEECCCCCCCCC		-
159	Ubiquitination	SGVLHCDLCSSPVKY CCCCCCCCCCCCCEE		-
184	Ubiquitination	FCRTPDYQGHFIVLR EEECCCCCCCEEEEE		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:24743017

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GUCD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GUCD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NEDD4_MOUSE	Nedd4	physical	24743017
ELAV3_MOUSE	Elavl3	physical	24743017
NEDD4_HUMAN	NEDD4	physical	24743017
K1C40_HUMAN	KRT40	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.