| UniProt ID | ELAV3_MOUSE | |
|---|---|---|
| UniProt AC | Q60900 | |
| Protein Name | ELAV-like protein 3 | |
| Gene Name | Elavl3 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 367 | |
| Subcellular Localization | ||
| Protein Description | Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance.. | |
| Protein Sequence | MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILLDQATGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 69 | Ubiquitination | IGDIESCKLVRDKIT CCCHHHCEEEEECCC | 60.33 | 22790023 | |
| 69 (in isoform 2) | Ubiquitination | - | 60.33 | 22790023 | |
| 94 | Ubiquitination | YSDPNDADKAINTLN CCCCCCHHHHHHHHH | 43.73 | 27667366 | |
| 95 | Ubiquitination | SDPNDADKAINTLNG CCCCCHHHHHHHHHC | 53.54 | 22790023 | |
| 95 (in isoform 2) | Ubiquitination | - | 53.54 | 22790023 | |
| 104 (in isoform 2) | Ubiquitination | - | 39.69 | 22790023 | |
| 104 | Ubiquitination | INTLNGLKLQTKTIK HHHHHCCEEEEEEEE | 39.69 | 22790023 | |
| 113 | Phosphorylation | QTKTIKVSYARPSSA EEEEEEEEEECCCCC | 14.20 | 29899451 | |
| 114 | Phosphorylation | TKTIKVSYARPSSAS EEEEEEEEECCCCCC | 15.04 | 29899451 | |
| 118 | Phosphorylation | KVSYARPSSASIRDA EEEEECCCCCCCCCC | 32.74 | 28066266 | |
| 119 | Phosphorylation | VSYARPSSASIRDAN EEEECCCCCCCCCCC | 28.81 | 22817900 | |
| 121 | Phosphorylation | YARPSSASIRDANLY EECCCCCCCCCCCEE | 21.80 | 28066266 | |
| 134 (in isoform 2) | Ubiquitination | - | 63.00 | 22790023 | |
| 134 | Ubiquitination | LYVSGLPKTMSQKEM EEECCCCCCCCHHHH | 63.00 | 22790023 | |
| 139 | Ubiquitination | LPKTMSQKEMEQLFS CCCCCCHHHHHHHHH | 52.28 | 22790023 | |
| 139 (in isoform 2) | Ubiquitination | - | 52.28 | 22790023 | |
| 208 | Ubiquitination | KFANNPSQKTGQALL EECCCCCHHHHHHHH | 48.89 | 27667366 | |
| 209 (in isoform 2) | Ubiquitination | - | 59.98 | 22790023 | |
| 209 | Ubiquitination | FANNPSQKTGQALLT ECCCCCHHHHHHHHH | 59.98 | 22790023 | |
| 225 | Methylation | LYQSSARRYAGPLHH HHHHHHHHHCCCCCC | 25.93 | - | |
| 236 | Methylation | PLHHQTQRFRLDNLL CCCCCCHHHHHHHHH | 23.26 | - | |
| 236 | Dimethylation | PLHHQTQRFRLDNLL CCCCCCHHHHHHHHH | 23.26 | - | |
| 251 | Phosphorylation | NMAYGVKSPLSLIAR HHHHCCCCHHHHHHH | 28.77 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ELAV3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ELAV3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ELAV3_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ELAV3_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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