GCM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCM2_HUMAN
• UniProt AC: O75603
• Protein Name: Chorion-specific transcription factor GCMb
• Gene Name: GCM2 {ECO:0000312|HGNC:HGNC:4198}
• Organism: Homo sapiens (Human).
• Sequence Length: 506
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development..
• Protein Sequence: MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
166	Phosphorylation	HPRPESKSETEARRS CCCCCCCCHHHHHHH	60.06	22210691
168	Phosphorylation	RPESKSETEARRSAI CCCCCCHHHHHHHHH	41.87	22210691
193	Phosphorylation	QKKRIRESEAEENQD HHHHHHHHHHHHCCC	32.05	26330541
201	Phosphorylation	EAEENQDSSGHFSNI HHHHCCCCCCCCCCC	28.58	26330541
202	Phosphorylation	AEENQDSSGHFSNIP HHHCCCCCCCCCCCC	44.57	26330541
206	Phosphorylation	QDSSGHFSNIPPLEN CCCCCCCCCCCCCCC	28.33	26330541
221	Phosphorylation	PEDFDIVTETSFPIP HHHCCEEEECCCCCC	33.60	26330541
223	Phosphorylation	DFDIVTETSFPIPGQ HCCEEEECCCCCCCC	26.71	26330541
224	Phosphorylation	FDIVTETSFPIPGQP CCEEEECCCCCCCCC	23.85	26330541
234	Phosphorylation	IPGQPCPSFPKSDVY CCCCCCCCCCHHHHE	61.98	26330541
238	Phosphorylation	PCPSFPKSDVYKATC CCCCCCHHHHEEEEE	32.33	26330541
241	Phosphorylation	SFPKSDVYKATCDLA CCCHHHHEEEEEEEE	10.41	26330541
359	Phosphorylation	QAMATRPYYNPELPC EEEECCCCCCCCCCC	16.75	22817900
360	Phosphorylation	AMATRPYYNPELPCR EEECCCCCCCCCCCE	27.24	22817900
368	Phosphorylation	NPELPCRYLTTPPPG CCCCCCEECCCCCCC	18.34	23663014
370	Phosphorylation	ELPCRYLTTPPPGAP CCCCEECCCCCCCCC	28.46	23663014
371	Phosphorylation	LPCRYLTTPPPGAPA CCCEECCCCCCCCCC	31.07	23663014
381	Phosphorylation	PGAPALQTVITTTTK CCCCCCCEEEEECCC	18.09	23663014
384	Phosphorylation	PALQTVITTTTKVSY CCCCEEEEECCCEEE	17.47	23663014
385	Phosphorylation	ALQTVITTTTKVSYQ CCCEEEEECCCEEEE	22.73	23663014
386	Phosphorylation	LQTVITTTTKVSYQA CCEEEEECCCEEEEE	18.90	23663014
387	Phosphorylation	QTVITTTTKVSYQAY CEEEEECCCEEEEEC	27.62	23663014
435	Phosphorylation	EPWGPPVTVTRAASP CCCCCCEEEEECCCC	23.18	26434776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBPMS_HUMAN	RBPMS	physical	25416956
HSFY1_HUMAN	HSFY1	physical	25416956
CSTF1_HUMAN	CSTF1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 146200: Hypoparathyroidism, familial isolated (FIH)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.