UniProt ID | GCM2_HUMAN | |
---|---|---|
UniProt AC | O75603 | |
Protein Name | Chorion-specific transcription factor GCMb | |
Gene Name | GCM2 {ECO:0000312|HGNC:HGNC:4198} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 506 | |
Subcellular Localization | Nucleus . | |
Protein Description | Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.. | |
Protein Sequence | MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
166 | Phosphorylation | HPRPESKSETEARRS CCCCCCCCHHHHHHH | 60.06 | 22210691 | |
168 | Phosphorylation | RPESKSETEARRSAI CCCCCCHHHHHHHHH | 41.87 | 22210691 | |
193 | Phosphorylation | QKKRIRESEAEENQD HHHHHHHHHHHHCCC | 32.05 | 26330541 | |
201 | Phosphorylation | EAEENQDSSGHFSNI HHHHCCCCCCCCCCC | 28.58 | 26330541 | |
202 | Phosphorylation | AEENQDSSGHFSNIP HHHCCCCCCCCCCCC | 44.57 | 26330541 | |
206 | Phosphorylation | QDSSGHFSNIPPLEN CCCCCCCCCCCCCCC | 28.33 | 26330541 | |
221 | Phosphorylation | PEDFDIVTETSFPIP HHHCCEEEECCCCCC | 33.60 | 26330541 | |
223 | Phosphorylation | DFDIVTETSFPIPGQ HCCEEEECCCCCCCC | 26.71 | 26330541 | |
224 | Phosphorylation | FDIVTETSFPIPGQP CCEEEECCCCCCCCC | 23.85 | 26330541 | |
234 | Phosphorylation | IPGQPCPSFPKSDVY CCCCCCCCCCHHHHE | 61.98 | 26330541 | |
238 | Phosphorylation | PCPSFPKSDVYKATC CCCCCCHHHHEEEEE | 32.33 | 26330541 | |
241 | Phosphorylation | SFPKSDVYKATCDLA CCCHHHHEEEEEEEE | 10.41 | 26330541 | |
359 | Phosphorylation | QAMATRPYYNPELPC EEEECCCCCCCCCCC | 16.75 | 22817900 | |
360 | Phosphorylation | AMATRPYYNPELPCR EEECCCCCCCCCCCE | 27.24 | 22817900 | |
368 | Phosphorylation | NPELPCRYLTTPPPG CCCCCCEECCCCCCC | 18.34 | 23663014 | |
370 | Phosphorylation | ELPCRYLTTPPPGAP CCCCEECCCCCCCCC | 28.46 | 23663014 | |
371 | Phosphorylation | LPCRYLTTPPPGAPA CCCEECCCCCCCCCC | 31.07 | 23663014 | |
381 | Phosphorylation | PGAPALQTVITTTTK CCCCCCCEEEEECCC | 18.09 | 23663014 | |
384 | Phosphorylation | PALQTVITTTTKVSY CCCCEEEEECCCEEE | 17.47 | 23663014 | |
385 | Phosphorylation | ALQTVITTTTKVSYQ CCCEEEEECCCEEEE | 22.73 | 23663014 | |
386 | Phosphorylation | LQTVITTTTKVSYQA CCEEEEECCCEEEEE | 18.90 | 23663014 | |
387 | Phosphorylation | QTVITTTTKVSYQAY CEEEEECCCEEEEEC | 27.62 | 23663014 | |
435 | Phosphorylation | EPWGPPVTVTRAASP CCCCCCEEEEECCCC | 23.18 | 26434776 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GCM2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GCM2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GCM2_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
RBPMS_HUMAN | RBPMS | physical | 25416956 | |
HSFY1_HUMAN | HSFY1 | physical | 25416956 | |
CSTF1_HUMAN | CSTF1 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
146200 | Hypoparathyroidism, familial isolated (FIH) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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