NRL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRL_HUMAN
• UniProt AC: P54845
• Protein Name: Neural retina-specific leucine zipper protein
• Gene Name: NRL
• Organism: Homo sapiens (Human).
• Sequence Length: 237
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. [PubMed: 21981118 Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3]
• Protein Sequence: MALPPSPLAMEYVNDFDLMKFEVKREPSEGRPGPPTASLGSTPYSSVPPSPTFSEPGMVGATEGTRPGLEELYWLATLQQQLGAGEALGLSPEEAMELLQGQGPVPVDGPHGYYPGSPEETGAQHVQLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSSGPGSGDPSHLFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Sumoylation	VNDFDLMKFEVKREP CCHHHCEEEEEECCC	45.75	-
20	Sumoylation	VNDFDLMKFEVKREP CCHHHCEEEEEECCC	45.75	-
24	Sumoylation	DLMKFEVKREPSEGR HCEEEEEECCCCCCC	43.79	-
36	Phosphorylation	EGRPGPPTASLGSTP CCCCCCCCCCCCCCC	31.82	-
50	Phosphorylation	PYSSVPPSPTFSEPG CCCCCCCCCCCCCCC	30.42	17335001
52	Phosphorylation	SSVPPSPTFSEPGMV CCCCCCCCCCCCCCC	44.10	-
54	Phosphorylation	VPPSPTFSEPGMVGA CCCCCCCCCCCCCCC	45.41	22210691
62	Phosphorylation	EPGMVGATEGTRPGL CCCCCCCCCCCCCCH	29.08	22210691
65	Phosphorylation	MVGATEGTRPGLEEL CCCCCCCCCCCHHHH	27.71	22210691
229	Phosphorylation	LTSSGPGSGDPSHLF HCCCCCCCCCHHHCC	43.06	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
20	K	Sumoylation	Disumoylated at Lys-20.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FIZ1_HUMAN	FIZ1	physical	12566383
CRX_BOVIN	CRX	physical	10887186
OPTN_HUMAN	OPTN	physical	23956131
NR2E3_HUMAN	NR2E3	physical	25703721

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613750: Retinitis pigmentosa 27 (RP27)
• 162080: Retinal degeneration autosomal recessive clumped pigment type (RDCP)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.