| UniProt ID | FIZ1_HUMAN | |
|---|---|---|
| UniProt AC | Q96SL8 | |
| Protein Name | Flt3-interacting zinc finger protein 1 | |
| Gene Name | FIZ1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 496 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).. | |
| Protein Sequence | MDDVPAPTPAPAPPAAAAPRVPFHCSECGKSFRYRSDLRRHFARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQVVHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGVLPSPLQPGPGLPALSAPCSVCCNVGPCSVCGGSGAGGGEGPEGAGAGLGSWGLAEAAAAAAASLPPFACGACARRFDHGRELAAHWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGPGAPPAQAWAAGPGAGPETAGEGTAAEAGDAPLASDRRLLLGPAGGGVPKLGGLLPEGGGEAPAPAAAAEPSEDTLYQCDCGTFFASAAALASHLEAHSGPATYGCGHCGALYAALAALEEHRRVSHGEGGGEEAATAAREREPASGEPPSGSGRGKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGKFFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDDVPAPT -------CCCCCCCC | 10.03 | 22814378 | |
| 46 | Phosphorylation | RRHFARHTALKPHAC HHHHHHHHHCCCCCC | 28.29 | 28555341 | |
| 63 | Phosphorylation | CGKGFKHSFNLANHL CCCCCHHCHHHHHHH | 19.20 | 28555341 | |
| 74 | Phosphorylation | ANHLRSHTGERPYRC HHHHHHCCCCCCCCC | 41.82 | 29496963 | |
| 102 | Phosphorylation | LHHQVVHTGEKPYCC CCEEEEECCCCCEEE | 35.11 | 25159151 | |
| 107 | Phosphorylation | VHTGEKPYCCLVCEL EECCCCCEEEEEEEE | 13.58 | - | |
| 329 | Phosphorylation | AAEPSEDTLYQCDCG CCCCCCCCCEECCHH | 24.26 | - | |
| 400 | Phosphorylation | AREREPASGEPPSGS HHHCCCCCCCCCCCC | 55.17 | 28122231 | |
| 405 | Phosphorylation | PASGEPPSGSGRGKK CCCCCCCCCCCCCCE | 57.20 | 28122231 | |
| 409 | Methylation | EPPSGSGRGKKIFGC CCCCCCCCCCEEECC | 56.29 | - | |
| 437 | Phosphorylation | ERHVLVHTGEKPFPC HCCEEEECCCCCCCE | 39.29 | 25159151 | |
| 449 | Ubiquitination | FPCLECGKFFRHECY CCEEHHCCEECCHHH | 53.65 | - | |
| 481 | Phosphorylation | ICGKGFITLSNLSRH CCCCCEEEHHHHHHH | 23.13 | - | |
| 483 | Phosphorylation | GKGFITLSNLSRHLK CCCEEEHHHHHHHHH | 27.37 | - | |
| 486 | Phosphorylation | FITLSNLSRHLKLHR EEEHHHHHHHHHHHC | 23.16 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FIZ1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FIZ1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FIZ1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FIZ1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74, AND MASSSPECTROMETRY. | |
