PCLI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCLI1_HUMAN
• UniProt AC: Q7Z2X4
• Protein Name: PTB-containing, cubilin and LRP1-interacting protein
• Gene Name: PID1
• Organism: Homo sapiens (Human).
• Sequence Length: 250
• Subcellular Localization: Cytoplasm .
• Protein Description: Increases proliferation of preadipocytes without affecting adipocytic differentiation..
• Protein Sequence: MFSLPLSLPLCEDTAFLPSKCCSSHKTIKQARTLIMIFLASGTHFQTMLKSKLNVLTLKKEPLPAVIFHEPEAIELCTTTPLMKTRTHSGCKVTYLGKVSTTGMQFLSGCTEKPVIELWKKHTLAREDVFPANALLEIRPFQVWLHHLDHKGEATVHMDTFQVARIAYCTADHNVSPNIFAWVYREINDDLSYQMDCHAVECESKLEAKKLAHAMMEAFRKTFHSMKSDGRIHSNSSSEEVSQELESDDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12 (in isoform 3)	Phosphorylation	-	67.11	22210691
13 (in isoform 3)	Phosphorylation	-	42.19	22210691
17	Ubiquitination	LCEDTAFLPSKCCSS CCCCCCCCCHHHHCC	4.31	29967540
19	Phosphorylation	EDTAFLPSKCCSSHK CCCCCCCHHHHCCCC	40.24	24719451
29 (in isoform 3)	Phosphorylation	-	43.04	22210691
55	Phosphorylation	MLKSKLNVLTLKKEP HHHHHCCEEECCCCC	6.65	27251275
57	Phosphorylation	KSKLNVLTLKKEPLP HHHCCEEECCCCCCC	32.04	27251275
87	Phosphorylation	TPLMKTRTHSGCKVT CCCCCCCCCCCCEEE	26.14	-
89	Phosphorylation	LMKTRTHSGCKVTYL CCCCCCCCCCEEEEE	45.32	-
223	Phosphorylation	MEAFRKTFHSMKSDG HHHHHHHHHHHCCCC	4.50	-
225	Phosphorylation	AFRKTFHSMKSDGRI HHHHHHHHHCCCCCC	24.58	24719451
232	Phosphorylation	SMKSDGRIHSNSSSE HHCCCCCCCCCCCHH	5.23	-
234	Phosphorylation	KSDGRIHSNSSSEEV CCCCCCCCCCCHHHH	35.72	28192239
236	Phosphorylation	DGRIHSNSSSEEVSQ CCCCCCCCCHHHHHH	37.95	28258704
237	Phosphorylation	GRIHSNSSSEEVSQE CCCCCCCCHHHHHHH	46.12	23927012
238	Phosphorylation	RIHSNSSSEEVSQEL CCCCCCCHHHHHHHH	37.28	23927012
242	Phosphorylation	NSSSEEVSQELESDD CCCHHHHHHHHHCCC	22.63	25072903
245	Phosphorylation	SEEVSQELESDDG-- HHHHHHHHHCCCC--	6.22	27251275
247	Phosphorylation	EVSQELESDDG---- HHHHHHHCCCC----	54.34	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCLI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCLI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCLI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRP4_HUMAN	LRP4	physical	20205790
CUBN_MOUSE	Cubn	physical	17124247
LRP1_MOUSE	Lrp1	physical	17124247
THAP1_HUMAN	THAP1	physical	25416956
GOPC_HUMAN	GOPC	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.