CUBN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUBN_MOUSE
• UniProt AC: Q9JLB4
• Protein Name: Cubilin
• Gene Name: Cubn
• Organism: Mus musculus (Mouse).
• Sequence Length: 3623
• Subcellular Localization: Apical cell membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Membrane, coated pit . Endosome . Lysosome membrane; Peripheral membrane protein. Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithel
• Protein Description: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface..
• Protein Sequence: MASHFLWGFVTLLMVPGLDGETGTPEQKLQKRIADLHQPRMTTEEGNLVFLTSSAQNIEFRTGSLGKIKLNDDDLGECLHQIQRNKDDIIDLKRNTTGLPQNILSQVHQLNSKLVDLERDFQSLQQNVERKVCSSNPCHNGGTCVNLHDSFICICPSQWKGLFCSEDVNECVLYAGTPFGCQSGSTCVNTMGSFRCDCTPDTYGPQCASKYNDCEQGSQQLCKHGICEDLQRVYHGQLRFNCICDAGWTTLPNGISCTEDKDECSLQPSPCSEHAQCFNTQGSFYCGACPKGWQGNGYQCQDINECEINNGGCSQAPLVPCLNTPGSFTCGNCPAGFSGDGRVCTPLDICSIHNGGCHPDATCSSSSVLGSLLPVCTCPPGYTGNGYGSNGCVRLSNMCSRHPCVNGQCIETVSSYFCKCDSGWFGQNCTENINECVSNPCLNGGTCIDGVNGFTCDCTSSWTGYYCQTPQAACGGILSGTQGTFAYQSPNDTYVHNVNCFWVVRTDEEKVLHITFTFFDLESASNCPREYLQIHDGDSSADFPLGRYCGSTPPQGVHSSANSLYFHLYSEYIKRGRGFTARWEAKLPECGGILTGNYGSITSPGYPGNYPPGRDCVWNLLVSPGSLITFTFGTLSLESHNDCSKDYLEIRDGPFHHDPILGKFCTSLSTPPLQTTGPAARIHFHSDSETSDKGFHITYLTTPSDLYCGGNYTDTEGELLLPPLTGPFSHSRQCVYLISQPQGEQIVINFTHVELESQRGCSHTFIEVGDHESLLRKICGNETLFPIRSISNNVWIRLRIDALVQKASFRADYQVACGGELRGEGVIRSPFYPNAYAGRRTCRWTISQPPREVVLLNFTDFQIGSSSSCDTDYIEIGPSSVLGSPGNEKFCGTNIPSFITSVYNVLYVTFVKSSSMENRGFMAMFSSEKLECGKVLTESTGIIESPGHPNVYPSGVNCTWHIVVQRGQLIRLVFSSFYLEFHYNCANDYLEVYDTIAQTSLGRYCGKSIPPSLTSSSHSIKLIFVSDSALAHEGFSINYEAINASSVCLYDYTDNFGRLSSPNFPNNYPHNWNCVYRITVGLNQQIALHFTDFALEDYFGPKCVDFVEIRDGGFETSPLIGIYCGSVFPPRIISHSNKLWLRFKSDTALTARGFSAYWDASSTGCGGNLTTPTGVLTSPNYPMPYYHSSECYWRLEASRGSPFLLEFQDFHLEHHPNCSLDYLAVFDGPSTNSRLINKLCGDTPPAPIRSSKDIVLLKLRTDAGQQGRGFEINYRQTCDNVVIVNKTSGILESINYPNPYDKDQRCNWTIQATTGNTVNYTFLEFDVENYVNCSTDYLELYDGPQRIGRYCGENIPPPGATTGSKLIVVFHTDGVDSGEKGFKMHWFIHGCGGEMSGTMGSFSSPGYPNSYPHNKECIWNIRVAPGNSIQLTIHDFDVEYHASCKYDTLEIYTGLDFHSPRIAQLCSRSPSANPMQISSTDNELAIRFKTDSSLNGRGFNASWRAVPGGCGGIFQVSRGEIHSPNYPNNYRANTECSWIIQVEKYHRVLLNITDFDLEATDSCLMTYDGSSSANTRVATVCGRQQPPNSITSSGNSLFVRFQSGSSSQSRGFRAQFRQECGAHIITDSSDSISSPLYPANYPNNQNCTWIIEAQPPFNHIALSFTHFHLQSSTDCTRDFVEILDGRDSDAPVQGRYCGTSLPHPIISFGNALTVRFVSDSVYGFDGFHAIYSASTSACGGTFYTGDGIFNSPGYPEDYHSNTECVWNIASSPGNHLQLSFLSFQLENSLNCNKDFVEIREGNATGHLMGRYCGNSLPGNYSSIEGHNLWVRFVSDGSGTGMGFQARFKNIFGNDNIVGTHGKIATPFWPGNYPLNSNYRWTVNVDSSHIIHGRILEMDIELTTNCFYDSLKIYDGFDIHSRLIGTYCGTQRESFSSSRNSLTFQFSSDSSKSGRGFLLEWFAVDVSNVTLPTIAPGACGGYMVTGDTPVFFFSPGWPGPYGNGADCIWIIYAPDSTVELNILSMDIEAQLSCSYDKLIIKDGDSRLSQQLAVLCGRSVPGPIRSTGEYMYIRFTSDGSVTGAGFNASFQKSCGGYLHADRGIITSPKYPDNYLPNLNCSWHVLVQSGLTIAVHFEQPFQIQNRDSSCSQGDYLVLRNGPDNHSPPLGPSGGNGRFCGIYTPSTLFTSDNEMFIQFISDNSNGGQGFKIRYEAKSLACGGTIYIHDANSDGYVTSPNYPANYPQHAECIWILEAPSGRSIQLQFEDQFNIEETPNCSASYLELRDGANSNAPVLSKLCGHTLPRNWVSSRGLMYLKFHTEGGSGYMGFKAKYSIVSCGGTVSGDSGVIESVGYPTRLYANNVFCQWHIQGLPGHYLTIRFEDFNLQSSPGCAKDFVEIWENHTSGILLGRYCGNSIPSSVDTSSNVASIRFVTDGSVTDSGFRLQFKSSREVCGGDLHGPTGTFTSPNYPNPNPHPRICEWTINVHEGRQIILTFTNLRLSTQQSCNTEHLIVFNGIRNNSPRLQKLCSRVNVTNEFKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGTLPSVSGGNFSSPGYNGIRDYARNLDCEWTLSNPNRENSSISIHFLGLSLESHQDCTFDVLEFRVGNADGPLIEKFCSLSAPRVPLVIPYPQVWIHFVSNERVEYTGFYVEYSFTNCGGIQTGENGVISSPNYPNLYSRWTQCSWLLEAPEGHTITLTFSDFSVENHPTCTSDSVTVRNGDSPGSPIIGRYCGQSVPGPIQSGSNQLVVTFNTNNQGQSRGFYATWNTNTLGCGGTLHSDNGTIKSPHWPQTFPENSRCSWTAVTHESKHWEISFDSNFRIPSSDSQCRNSFVKVWEGMLETNDALLATSCGNVAPSPIVTLGNIFTAVFQSEEMPAQGFSASFISRCGRTFNSSTGDIVSPNFPKHYDNNMNCNYYIDVAPQSLVILTFVSFHLEDRSAVSGTCDYDGLHIIKGHNLSSTPLVTICGSETLRPLTIDGPVMLNFYSDAYITDFGFKISYRVANCGGIYSGTYGVLNSPSFSYTNYPNNVYCVYSLQVRNDRLILLRFNDFEIVPSNLCSHDYLEVFDGPSIGNRSIGKFCGSTLPQVIKSTNNSLTLLFKTDSSQTARGWKVSFRETIGPQQGCGGYLTEDSKSFVSPDHDSDGLYDKGLNCIWYIIAPENKLVKLTFNAFTLEEPSSPGKCTFDYVQIADGASINSYLGGRFCGSSRPAPFISSGNFLTVQFVSDISIQMRGFNATYTFVDMPCGGTYNATSMPQNTSSPQLSNIRRPFSTCTWVIEAPPHQQVQITVWKLQLPSQDCSRSSLELQDSEQTNGNQVTQFCGANYTTLPVFYSSGSTAVVVFKSDFLNRNSRVHFTYEIADCNREYNQAFGNLKSPGWPQGYANNLDCSIILRAPQNHRISLFFYWFQLEDSRQCMNDFLEVRNGSSSSSPLLGKYCSNLLPNPIFSQSNELYLHFHSDDSDTHHGYEIIWASSPTGCGGTLLGNEGILANPGFPDSYPNNTHCEWTIVAPSGRPLSVGFPFLSIDSPGGCDQNYLILFNGPDANSPPFGPFCGIDTVVAPFHASSNRVFIRFHAEYATVSSGFEIMWSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	N-linked_Glycosylation	DIIDLKRNTTGLPQN CCEECCCCCCCCCHH	40.17	-
428	N-linked_Glycosylation	DSGWFGQNCTENINE CCCCCCCCCCCCHHH	34.75	-
491	N-linked_Glycosylation	TFAYQSPNDTYVHNV EEEEECCCCCEEEEE	60.55	-
626	Phosphorylation	NLLVSPGSLITFTFG HHEECCCCEEEEEEE	21.71	24719451
711	N-linked_Glycosylation	SDLYCGGNYTDTEGE HHEECCCCCCCCCCC	23.09	-
749	N-linked_Glycosylation	QGEQIVINFTHVELE CCCEEEEEEEEEEEE	25.52	-
781	N-linked_Glycosylation	LLRKICGNETLFPIR HHHHHHCCCCEEEEE	34.37	-
857	N-linked_Glycosylation	PREVVLLNFTDFQIG CCEEEEEECCCCCCC	33.34	-
957	N-linked_Glycosylation	NVYPSGVNCTWHIVV CCCCCCCCCEEEEEE	22.49	-
1016	Phosphorylation	IPPSLTSSSHSIKLI CCCCCCCCCCCEEEE	27.17	22942356
1043	N-linked_Glycosylation	SINYEAINASSVCLY CCCHHHCCCCEEEEE	40.60	-
1168	N-linked_Glycosylation	SSTGCGGNLTTPTGV CCCCCCCCCCCCCCC	21.35	-
1217	N-linked_Glycosylation	FHLEHHPNCSLDYLA HHCCCCCCCCCCEEE	24.53	-
1285	N-linked_Glycosylation	CDNVVIVNKTSGILE CCEEEEEECCCCHHH	30.66	-
1307	N-linked_Glycosylation	YDKDQRCNWTIQATT CCCCCCCCEEEEECC	40.91	-
1319	N-linked_Glycosylation	ATTGNTVNYTFLEFD ECCCCCEEEEEEEEE	28.26	-
1332	N-linked_Glycosylation	FDVENYVNCSTDYLE EEHHHCEECCCCEEE	12.03	-
1500	N-linked_Glycosylation	SLNGRGFNASWRAVP CCCCCCCEEEEEECC	35.57	-
1534	Phosphorylation	PNNYRANTECSWIIQ CCCCCCCCCCCEEEE	37.07	24719451
1551	N-linked_Glycosylation	KYHRVLLNITDFDLE EEEEEEEECCCCCCE	30.84	-
1603	Phosphorylation	SLFVRFQSGSSSQSR EEEEEEECCCCCCCC	37.62	30635358
1605	Phosphorylation	FVRFQSGSSSQSRGF EEEEECCCCCCCCCH	31.87	30635358
1606	Phosphorylation	VRFQSGSSSQSRGFR EEEECCCCCCCCCHH	35.60	30635358
1607	Phosphorylation	RFQSGSSSQSRGFRA EEECCCCCCCCCHHH	33.59	30635358
1609	Phosphorylation	QSGSSSQSRGFRAQF ECCCCCCCCCHHHHH	36.00	30635358
1646	N-linked_Glycosylation	ANYPNNQNCTWIIEA CCCCCCCCEEEEEEE	27.58	-
1802	N-linked_Glycosylation	FVEIREGNATGHLMG EEEEECCCCCCCEEE	29.58	-
1804	Phosphorylation	EIREGNATGHLMGRY EEECCCCCCCEEECC	29.18	-
1819	N-linked_Glycosylation	CGNSLPGNYSSIEGH CCCCCCCCCCCCCCC	31.41	-
1967	N-linked_Glycosylation	WFAVDVSNVTLPTIA EEEEECCCCCCCCCC	30.55	-
2085	N-linked_Glycosylation	SVTGAGFNASFQKSC CEECCEECEEHHHHH	33.48	19349973
2117	N-linked_Glycosylation	DNYLPNLNCSWHVLV CCCCCCCCCEEEEEE	25.15	-
2274	N-linked_Glycosylation	FNIEETPNCSASYLE CCCCCCCCCCEEEEE	39.53	-
2400	N-linked_Glycosylation	DFVEIWENHTSGILL HHHHHHHHCCCCEEE	28.83	-
2531	N-linked_Glycosylation	QKLCSRVNVTNEFKS HHHHHCCCCCCHHHC	33.51	-
2538	Phosphorylation	NVTNEFKSSGNTMKV CCCCHHHCCCCEEEE	49.12	21659604
2581	N-linked_Glycosylation	LPSVSGGNFSSPGYN CCCCCCCCCCCCCCC	36.83	-
2610	N-linked_Glycosylation	LSNPNRENSSISIHF CCCCCCCCCCEEEEE	37.51	-
2813	N-linked_Glycosylation	GGTLHSDNGTIKSPH CCEEECCCCCCCCCC	53.15	-
2925	N-linked_Glycosylation	SRCGRTFNSSTGDIV HHCCCCCCCCCCCCC	34.14	19349973
2989	N-linked_Glycosylation	LHIIKGHNLSSTPLV CEEEECCCCCCCCEE	50.73	-
3008	Phosphorylation	SETLRPLTIDGPVML CCCCCEEEECCCEEE	21.50	-
3106	N-linked_Glycosylation	FDGPSIGNRSIGKFC CCCCCCCCCHHHHHC	32.62	-
3125	N-linked_Glycosylation	PQVIKSTNNSLTLLF HHHHHHCCCCEEEEE	43.09	19349973
3200	Phosphorylation	ENKLVKLTFNAFTLE CCCEEEEEEEEEECC	14.77	27357545
3210	Phosphorylation	AFTLEEPSSPGKCTF EEECCCCCCCCCCEE	53.06	27357545
3268	N-linked_Glycosylation	SIQMRGFNATYTFVD EEEECCCCEEEEEEE	33.91	-
3283	N-linked_Glycosylation	MPCGGTYNATSMPQN CCCCCCCCCCCCCCC	36.26	-
3290	N-linked_Glycosylation	NATSMPQNTSSPQLS CCCCCCCCCCCCCHH	35.74	-
3357	N-linked_Glycosylation	VTQFCGANYTTLPVF EECCCCCCCCCEEEE	21.70	-
3434	Phosphorylation	APQNHRISLFFYWFQ CCCCCCEEEEEEEEE	21.05	24759943
3457	N-linked_Glycosylation	NDFLEVRNGSSSSSP HHHEEECCCCCCCCC	60.93	-
3533	N-linked_Glycosylation	GFPDSYPNNTHCEWT CCCCCCCCCCCEEEE	58.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CUBN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUBN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUBN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CUBN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2085; ASN-2925 ANDASN-3125, AND MASS SPECTROMETRY.
PubMed: 19349973