dbPTM

UBX2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBX2B_HUMAN
UniProt AC	Q14CS0
Protein Name	UBX domain-containing protein 2B
Gene Name	UBXN2B
Organism	Homo sapiens (Human).
Sequence Length	331
Subcellular Localization	Nucleus . Cytoplasm, cytosol . Endoplasmic reticulum . Golgi apparatus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to centrosome during mitotic prophase and metaphase.
Protein Description	Adapter protein required for Golgi and endoplasmic reticulum biogenesis. [PubMed: 17141156 Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis]
Protein Sequence	MAEGGGPEPGEQERRSSGPRPPSARDLQLALAELYEDEVKCKSSKSNRPKATVFKSPRTPPQRFYSSEHEYSGLNIVRPSTGKIVNELFKEAREHGAVPLNEATRASGDDKSKSFTGGGYRLGSSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDDGELRPYNEPTNAQFLESVKRGEIPLELQRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVQSRPEFAALDFILVTSFPNKELTDESLTLLEADILNTVLLQQLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEGGGPEP ------CCCCCCCCC	24.92	22814378
16	Phosphorylation	PGEQERRSSGPRPPS CCHHCCCCCCCCCCC	45.96	20873877
17	Phosphorylation	GEQERRSSGPRPPSA CHHCCCCCCCCCCCH	51.51	25159151
23	Phosphorylation	SSGPRPPSARDLQLA CCCCCCCCHHHHHHH	38.32	24670416
35	Phosphorylation	QLALAELYEDEVKCK HHHHHHHHHCHHHCC	16.91	28796482
40	Ubiquitination	ELYEDEVKCKSSKSN HHHHCHHHCCCCCCC	33.62	-
46	Phosphorylation	VKCKSSKSNRPKATV HHCCCCCCCCCCCEE	39.76	-
50	Ubiquitination	SSKSNRPKATVFKSP CCCCCCCCCEEECCC	54.15	-
52	Phosphorylation	KSNRPKATVFKSPRT CCCCCCCEEECCCCC	32.38	29449344
55	Ubiquitination	RPKATVFKSPRTPPQ CCCCEEECCCCCCCH	56.04	-
55	Methylation	RPKATVFKSPRTPPQ CCCCEEECCCCCCCH	56.04	115978971
56	Phosphorylation	PKATVFKSPRTPPQR CCCEEECCCCCCCHH	14.24	25159151
59	Phosphorylation	TVFKSPRTPPQRFYS EEECCCCCCCHHCCC	42.58	25159151
65	Phosphorylation	RTPPQRFYSSEHEYS CCCCHHCCCCCCCCC	17.30	28450419
66	Phosphorylation	TPPQRFYSSEHEYSG CCCHHCCCCCCCCCC	26.91	27273156
67	Phosphorylation	PPQRFYSSEHEYSGL CCHHCCCCCCCCCCC	31.43	26657352
71	Phosphorylation	FYSSEHEYSGLNIVR CCCCCCCCCCCCEEC	15.22	23927012
72	Phosphorylation	YSSEHEYSGLNIVRP CCCCCCCCCCCEECC	33.54	28450419
80	Phosphorylation	GLNIVRPSTGKIVNE CCCEECCCCHHHHHH	38.95	27251275
81	Phosphorylation	LNIVRPSTGKIVNEL CCEECCCCHHHHHHH	45.22	27251275
83	Ubiquitination	IVRPSTGKIVNELFK EECCCCHHHHHHHHH	43.50	-
90	Ubiquitination	KIVNELFKEAREHGA HHHHHHHHHHHHHCC	64.19	-
104	Phosphorylation	AVPLNEATRASGDDK CEECCHHHHHCCCCC	22.16	28555341
107	Phosphorylation	LNEATRASGDDKSKS CCHHHHHCCCCCCCC	39.19	-
112	Phosphorylation	RASGDDKSKSFTGGG HHCCCCCCCCCCCCC	40.29	-
113	Ubiquitination	ASGDDKSKSFTGGGY HCCCCCCCCCCCCCC	56.16	-
114	Phosphorylation	SGDDKSKSFTGGGYR CCCCCCCCCCCCCCC	34.82	-
125	Phosphorylation	GGYRLGSSFCKRSEY CCCCCCCCHHCCHHC	32.63	27251275
128	Ubiquitination	RLGSSFCKRSEYIYG CCCCCHHCCHHCCCC	57.88	-
132	Phosphorylation	SFCKRSEYIYGENQL CHHCCHHCCCCCCHH	10.73	29978859
134	Phosphorylation	CKRSEYIYGENQLQD HCCHHCCCCCCHHHH	19.93	29978859
154	Phosphorylation	KLWSNGFSLDDGELR HHHHCCCCCCCCCCC	32.08	28348404
163	Phosphorylation	DDGELRPYNEPTNAQ CCCCCCCCCCCCCHH	26.23	28348404
167	Phosphorylation	LRPYNEPTNAQFLES CCCCCCCCCHHHHHH	36.69	28348404
176	Ubiquitination	AQFLESVKRGEIPLE HHHHHHHHCCCCCHH	65.06	21906983
205	Phosphorylation	EDHQDQEYIKPRLRF CCCCCHHHCCCCEEE	14.49	29978859
207	Ubiquitination	HQDQEYIKPRLRFKA CCCHHHCCCCEEEEE	24.15	-
213	Ubiquitination	IKPRLRFKAFSGEGQ CCCCEEEEEECCCCC	41.93	-
216	Phosphorylation	RLRFKAFSGEGQKLG CEEEEEECCCCCCCC	40.57	29978859
221	Ubiquitination	AFSGEGQKLGSLTPE EECCCCCCCCCCCCC	66.72	-
224	Phosphorylation	GEGQKLGSLTPEIVS CCCCCCCCCCCCHHC	39.23	30278072
226	Phosphorylation	GQKLGSLTPEIVSTP CCCCCCCCCCHHCCC	22.14	30278072
231	Phosphorylation	SLTPEIVSTPSSPEE CCCCCHHCCCCCHHH	40.02	30278072
232	Phosphorylation	LTPEIVSTPSSPEEE CCCCHHCCCCCHHHH	19.12	30278072
234	Phosphorylation	PEIVSTPSSPEEEDK CCHHCCCCCHHHHCC	59.62	29255136
235	Phosphorylation	EIVSTPSSPEEEDKS CHHCCCCCHHHHCCH	37.22	29255136
242	Phosphorylation	SPEEEDKSILNAVVL CHHHHCCHHHEEEEE	44.63	26657352
276	Phosphorylation	LIQRFNSTHRILDVR HHHHHHCCCCEEHHH	19.11	24719451
302	Phosphorylation	ALDFILVTSFPNKEL CCCEEEEECCCCCCC	22.62	28450419
303	Phosphorylation	LDFILVTSFPNKELT CCEEEEECCCCCCCC	31.09	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
56	S	Phosphorylation	Kinase	CDK1	P06493	PSP
59	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBX2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBX2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
INCA1_HUMAN	INCA1	physical	25416956
TERA_HUMAN	VCP	physical	26186194
MRCKB_HUMAN	CDC42BPB	physical	26186194
NIF3L_HUMAN	NIF3L1	physical	26186194
PP1R7_HUMAN	PPP1R7	physical	26186194
PP1RB_HUMAN	PPP1R11	physical	26186194
ASPC1_HUMAN	ASPSCR1	physical	26186194
ARP6_HUMAN	ACTR6	physical	26186194
F104A_HUMAN	FAM104A	physical	26186194
ASPC1_HUMAN	ASPSCR1	physical	26389662
PP1R7_HUMAN	PPP1R7	physical	26389662
VCIP1_HUMAN	VCPIP1	physical	26389662
PP1RB_HUMAN	PPP1R11	physical	26389662
TERA_HUMAN	VCP	physical	26389662
LACTB_HUMAN	LACTB	physical	26389662
PP1A_HUMAN	PPP1CA	physical	26389662
PP1B_HUMAN	PPP1CB	physical	26389662
MRCKB_HUMAN	CDC42BPB	physical	26389662
SC24A_HUMAN	SEC24A	physical	26389662
F104A_HUMAN	FAM104A	physical	26389662
GSK3B_HUMAN	GSK3B	physical	26389662
HPBP1_HUMAN	HSPBP1	physical	26389662
KLH36_HUMAN	KLHL36	physical	26389662
PP1G_HUMAN	PPP1CC	physical	26389662
TRAF2_HUMAN	TRAF2	physical	26389662
UBR2_HUMAN	UBR2	physical	26389662
FAF1_HUMAN	FAF1	physical	26389662
F104A_HUMAN	FAM104A	physical	28514442
MRCKB_HUMAN	CDC42BPB	physical	28514442
ASPC1_HUMAN	ASPSCR1	physical	28514442
TERA_HUMAN	VCP	physical	28514442
ARP6_HUMAN	ACTR6	physical	28514442
PP1R7_HUMAN	PPP1R7	physical	28514442
FA89A_HUMAN	FAM89A	physical	28514442
PP1RB_HUMAN	PPP1R11	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBX2B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-235, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-232; SER-234 ANDSER-235, AND MASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND THR-59, AND MASSSPECTROMETRY.	18669648 [Abstract]