PSB10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSB10_HUMAN
• UniProt AC: P40306
• Protein Name: Proteasome subunit beta type-10
• Gene Name: PSMB10
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Cytoplasm . Nucleus.
• Protein Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides..
• Protein Sequence: MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLKPALEP -------CCCCCCCC	11.08	22814378
3	Ubiquitination	-----MLKPALEPRG -----CCCCCCCCCC	27.26	24816145
22	Phosphorylation	ENCQRNASLERVLPG CCCCCCCCHHHHCCC	34.02	27067055
31	Ubiquitination	ERVLPGLKVPHARKT HHHCCCCCCCCCCCC	60.68	21906983
37	Ubiquitination	LKVPHARKTGTTIAG CCCCCCCCCCCEEEE	52.68	29967540
68	Ubiquitination	NDSVVADKSCEKIHF CCCEECCCCCCEEEE	47.47	21906983
72	Ubiquitination	VADKSCEKIHFIAPK ECCCCCCEEEEECCC	45.89	22817900
72	Acetylation	VADKSCEKIHFIAPK ECCCCCCEEEEECCC	45.89	25953088
79	Ubiquitination	KIHFIAPKIYCCGAG EEEEECCCEEECCCC	36.97	29967540
101	Ubiquitination	TTRMVASKMELHALS HHHHHHHHHHHHHHH	27.02	22505724
101	Acetylation	TTRMVASKMELHALS HHHHHHHHHHHHHHH	27.02	25953088
108	Phosphorylation	KMELHALSTGREPRV HHHHHHHHCCCCCHH	29.60	27251275
109	Phosphorylation	MELHALSTGREPRVA HHHHHHHCCCCCHHH	40.90	27251275
158	Phosphorylation	GVHPHGSYSRLPFTA EECCCCCCCCCCEEE	11.47	20090780
168	Phosphorylation	LPFTALGSGQDAALA CCEEEECCCHHHHHH	33.85	30087585
223	Ubiquitination	VITKTGAKLLRTLSS EEEHHHHHHHHHCCC	49.77	25015289
223	Acetylation	VITKTGAKLLRTLSS EEEHHHHHHHHHCCC	49.77	23749302
227	Phosphorylation	TGAKLLRTLSSPTEP HHHHHHHHCCCCCCC	30.84	30266825
229	Phosphorylation	AKLLRTLSSPTEPVK HHHHHHCCCCCCCCC	33.39	30266825
230	Phosphorylation	KLLRTLSSPTEPVKR HHHHHCCCCCCCCCC	38.67	23401153
232	Phosphorylation	LRTLSSPTEPVKRSG HHHCCCCCCCCCCCC	55.67	30266825
236	Acetylation	SSPTEPVKRSGRYHF CCCCCCCCCCCCCEE	52.11	25953088
236	Ubiquitination	SSPTEPVKRSGRYHF CCCCCCCCCCCCCEE	52.11	21963094
241	Phosphorylation	PVKRSGRYHFVPGTT CCCCCCCCEECCCCC	11.79	-
247	Phosphorylation	RYHFVPGTTAVLTQT CCEECCCCCEEEEEE	12.91	22210691
252	Phosphorylation	PGTTAVLTQTVKPLT CCCCEEEEEECCCCH	18.65	22210691
259	Phosphorylation	TQTVKPLTLELVEET EEECCCCHHHHHHHH	27.06	-
266	Phosphorylation	TLELVEETVQAMEVE HHHHHHHHHHHHCCC	12.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSB10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSB10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSB10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN_HUMAN	PTN	physical	16169070
PSB3_HUMAN	PSMB3	physical	17506986
PSB3_HUMAN	PSMB3	physical	17948026
PSB3_HUMAN	PSMB3	physical	22939629
PSB4_HUMAN	PSMB4	physical	22939629
PSB6_HUMAN	PSMB6	physical	22939629
PSB1_HUMAN	PSMB1	physical	22939629
PSB5_HUMAN	PSMB5	physical	22939629
PSMD6_HUMAN	PSMD6	physical	22939629
CCDB1_HUMAN	CCNDBP1	physical	25416956
PSB3_HUMAN	PSMB3	physical	26344197
PSB4_HUMAN	PSMB4	physical	26344197
PSB5_HUMAN	PSMB5	physical	26344197
PSMD5_HUMAN	PSMD5	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB08889: Carfilzomib