ALG13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALG13_HUMAN
• UniProt AC: Q9NP73
• Protein Name: Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13
• Gene Name: ALG13
• Organism: Homo sapiens (Human).
• Sequence Length: 1137
• Subcellular Localization: Isoform 2: Endoplasmic reticulum . Could be recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14.
• Protein Description: Isoform 1: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities.; Isoform 2: May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway..
• Protein Sequence: MKCVFVTVGTTSFDDLIACVSAPDSLQKIESLGYNRLILQIGRGTVVPEPFSTESFTLDVYRYKDSLKEDIQKADLVISHAGAGSCLETLEKGKPLVVVINEKLMNNHQLELAKQLHKEGHLFYCTCRVLTCPGQAKSIASAPGKCQDSAALTSTAFSGLDFGLLSGYLHKQALVTATHPTCTLLFPSCHAFFPLPLTPTLYKMHKGWKNYCSQKSLNEASMDEYLGSLGLFRKLTAKDASCLFRAISEQLFCSQVHHLEIRKACVSYMRENQQTFESYVEGSFEKYLERLGDPKESAGQLEIRALSLIYNRDFILYRFPGKPPTYVTDNGYEDKILLCYSSSGHYDSVYSKQFQSSAAVCQAVLYEILYKDVFVVDEEELKTAIKLFRSGSKKNRNNAVTGSEDAHTDYKSSNQNRMEEWGACYNAENIPEGYNKGTEETKSPENPSKMPFPYKVLKALDPEIYRNVEFDVWLDSRKELQKSDYMEYAGRQYYLGDKCQVCLESEGRYYNAHIQEVGNENNSVTVFIEELAEKHVVPLANLKPVTQVMSVPAWNAMPSRKGRGYQKMPGGYVPEIVISEMDIKQQKKMFKKIRGKEVYMTMAYGKGDPLLPPRLQHSMHYGHDPPMHYSQTAGNVMSNEHFHPQHPSPRQGRGYGMPRNSSRFINRHNMPGPKVDFYPGPGKRCCQSYDNFSYRSRSFRRSHRQMSCVNKESQYGFTPGNGQMPRGLEETITFYEVEEGDETAYPTLPNHGGPSTMVPATSGYCVGRRGHSSGKQTLNLEEGNGQSENGRYHEEYLYRAEPDYETSGVYSTTASTANLSLQDRKSCSMSPQDTVTSYNYPQKMMGNIAAVAASCANNVPAPVLSNGAAANQAISTTSVSSQNAIQPLFVSPPTHGRPVIASPSYPCHSAIPHAGASLPPPPPPPPPPPPPPPPPPPPPPPPPPPALDVGETSNLQPPPPLPPPPYSCDPSGSDLPQDTKVLQYYFNLGLQCYYHSYWHSMVYVPQMQQQLHVENYPVYTEPPLVDQTVPQCYSEVRREDGIQAEASANDTFPNADSSSVPHGAVYYPVMSDPYGQPPLPGFDSCLPVVPDYSCVPPWHPVGTAYGGSSQIHGAINPGPIGCIAPSPPASHYVPQGM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	VFVTVGTTSFDDLIA EEEEECCCCHHHHHH	22.82	68695273
64	Ubiquitination	TLDVYRYKDSLKEDI EEEEEECHHHHHHHH	31.66	-
68	Ubiquitination	YRYKDSLKEDIQKAD EECHHHHHHHHHHCC	58.24	-
73	Ubiquitination	SLKEDIQKADLVISH HHHHHHHHCCEEEEC	44.17	-
92	Ubiquitination	SCLETLEKGKPLVVV CHHHHHHCCCCEEEE	75.29	-
94	Ubiquitination	LETLEKGKPLVVVIN HHHHHCCCCEEEEEC	46.36	-
103	Ubiquitination	LVVVINEKLMNNHQL EEEEECHHHCCHHHH	48.85	-
105	Sulfoxidation	VVINEKLMNNHQLEL EEECHHHCCHHHHHH	7.55	21406390
114	Ubiquitination	NHQLELAKQLHKEGH HHHHHHHHHHHHCCC	67.05	21890473
114	Ubiquitination	NHQLELAKQLHKEGH HHHHHHHHHHHHCCC	67.05	21890473
114	Ubiquitination	NHQLELAKQLHKEGH HHHHHHHHHHHHCCC	67.05	21890473
114	Ubiquitination	NHQLELAKQLHKEGH HHHHHHHHHHHHCCC	67.05	21890473
114	Ubiquitination	NHQLELAKQLHKEGH HHHHHHHHHHHHCCC	67.05	21890473
159 (in isoform 2)	Ubiquitination	-	23.86	-
215	Ubiquitination	WKNYCSQKSLNEASM HHHHCCHHHCCHHHH	40.39	-
216	Phosphorylation	KNYCSQKSLNEASMD HHHCCHHHCCHHHHH	28.88	27732954
221	Phosphorylation	QKSLNEASMDEYLGS HHHCCHHHHHHHHHH	22.16	27050516
238	Ubiquitination	LFRKLTAKDASCLFR HHHHHCHHHHHHHHH	48.90	-
307	Phosphorylation	QLEIRALSLIYNRDF HHHHHHHHHHHCCCE	16.25	27174698
310	Phosphorylation	IRALSLIYNRDFILY HHHHHHHHCCCEEEE	14.94	27174698
317	Phosphorylation	YNRDFILYRFPGKPP HCCCEEEEECCCCCC	12.85	27174698
382	Ubiquitination	VVDEEELKTAIKLFR ECCHHHHHHHHHHHH	38.91	-
386	Ubiquitination	EELKTAIKLFRSGSK HHHHHHHHHHHCCCC	38.82	-
411	Ubiquitination	EDAHTDYKSSNQNRM CHHHCCCCCCCCCHH	50.66	-
438	Phosphorylation	PEGYNKGTEETKSPE CCCCCCCCCCCCCCC	32.05	25262027
441	Phosphorylation	YNKGTEETKSPENPS CCCCCCCCCCCCCCC	30.50	25262027
443	Phosphorylation	KGTEETKSPENPSKM CCCCCCCCCCCCCCC	44.88	113334281
448	Phosphorylation	TKSPENPSKMPFPYK CCCCCCCCCCCCCHH	53.84	113334287
455	Ubiquitination	SKMPFPYKVLKALDP CCCCCCHHHHHHCCH	41.13	-
458	Ubiquitination	PFPYKVLKALDPEIY CCCHHHHHHCCHHHH	50.30	-
482	Ubiquitination	DSRKELQKSDYMEYA CCCHHHHHCHHHHHC	58.90	-
483	Phosphorylation	SRKELQKSDYMEYAG CCHHHHHCHHHHHCC	22.48	25690035
485	Phosphorylation	KELQKSDYMEYAGRQ HHHHHCHHHHHCCCC	10.03	27642862
488	Phosphorylation	QKSDYMEYAGRQYYL HHCHHHHHCCCCEEC	9.60	27642862
498	Ubiquitination	RQYYLGDKCQVCLES CCEECCCCCEEEEHH	25.43	-
559	Phosphorylation	PAWNAMPSRKGRGYQ CCHHCCCCCCCCCCC	33.27	22210691
567	Ubiquitination	RKGRGYQKMPGGYVP CCCCCCCCCCCCCCC	38.28	-
584	Ubiquitination	VISEMDIKQQKKMFK EEEECCHHHHHHHHH	42.27	-
604	Phosphorylation	EVYMTMAYGKGDPLL EEEEEEECCCCCCCC	14.46	68701979
648	Phosphorylation	HFHPQHPSPRQGRGY CCCCCCCCCCCCCCC	30.50	17081983
655	Phosphorylation	SPRQGRGYGMPRNSS CCCCCCCCCCCCCHH	14.64	50564639
662	Phosphorylation	YGMPRNSSRFINRHN CCCCCCHHHCHHHCC	34.46	22210691
683	Ubiquitination	DFYPGPGKRCCQSYD CCCCCCCCCCCCCCC	45.45	-
711	Ubiquitination	RQMSCVNKESQYGFT CCHHCCCCCHHCCCC	38.04	-
775	Ubiquitination	RRGHSSGKQTLNLEE CCCCCCCCEEEECCC	41.90	-
830	Phosphorylation	DRKSCSMSPQDTVTS CCCCCCCCCCCCHHC	11.78	25159151
834	Phosphorylation	CSMSPQDTVTSYNYP CCCCCCCCHHCCCCC	22.04	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALG13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALG13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALG13_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ALG13_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.