PCBP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCBP4_HUMAN
• UniProt AC: P57723
• Protein Name: Poly(rC)-binding protein 4
• Gene Name: PCBP4
• Organism: Homo sapiens (Human).
• Sequence Length: 403
• Subcellular Localization: Cytoplasm .
• Protein Description: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC..
• Protein Sequence: MSGSDGGLEEEPELSITLTLRMLMHGKEVGSIIGKKGETVKRIREQSSARITISEGSCPERITTITGSTAAVFHAVSMIAFKLDEDLCAAPANGGNVSRPPVTLRLVIPASQCGSLIGKAGTKIKEIRETTGAQVQVAGDLLPNSTERAVTVSGVPDAIILCVRQICAVILESPPKGATIPYHPSLSLGTVLLSANQGFSVQGQYGAVTPAEVTKLQQLSSHAVPFATPSVVPGLDPGTQTSSQEFLVPNDLIGCVIGRQGSKISEIRQMSGAHIKIGNQAEGAGERHVTITGSPVSIALAQYLITACLETAKSTSGGTPSSAPADLPAPFSPPLTALPTAPPGLLGTPYAISLSNFIGLKPMPFLALPPASPGPPPGLAAYTAKMAAANGSKKAERQKFSPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGSDGGLE ------CCCCCCCCC	47.18	29507054
4	Phosphorylation	----MSGSDGGLEEE ----CCCCCCCCCCC	26.27	29507054
31	Phosphorylation	MHGKEVGSIIGKKGE HCCHHHHHHHCCCCH	19.06	30108239
35	Acetylation	EVGSIIGKKGETVKR HHHHHHCCCCHHHHH	47.39	7614129
35 (in isoform 2)	Ubiquitination	-	47.39	21906983
35 (in isoform 1)	Ubiquitination	-	47.39	21906983
35	Sumoylation	EVGSIIGKKGETVKR HHHHHHCCCCHHHHH	47.39	-
35	Ubiquitination	EVGSIIGKKGETVKR HHHHHHCCCCHHHHH	47.39	21906983
35	Sumoylation	EVGSIIGKKGETVKR HHHHHHCCCCHHHHH	47.39	-
36	Ubiquitination	VGSIIGKKGETVKRI HHHHHCCCCHHHHHH	57.68	-
77	Phosphorylation	AAVFHAVSMIAFKLD HHHHHHHHHHHHCCC	12.78	-
119	Ubiquitination	QCGSLIGKAGTKIKE HHHHHHHHCCCCHHH	36.33	-
130	Phosphorylation	KIKEIRETTGAQVQV CHHHHHHHHCCEEEE	22.23	22210691
131	Phosphorylation	IKEIRETTGAQVQVA HHHHHHHHCCEEEEE	26.26	22210691
146	Phosphorylation	GDLLPNSTERAVTVS CCCCCCCCCCCEECC	35.81	22210691
262	Phosphorylation	CVIGRQGSKISEIRQ EHHCCCCCCHHHHHH	20.62	-
263	Ubiquitination	VIGRQGSKISEIRQM HHCCCCCCHHHHHHH	58.01	-
265	Phosphorylation	GRQGSKISEIRQMSG CCCCCCHHHHHHHCC	30.61	24719451
382	Phosphorylation	PPPGLAAYTAKMAAA CCCCHHHHHHHHHHH	11.13	24719451
383	Phosphorylation	PPGLAAYTAKMAAAN CCCHHHHHHHHHHHC	18.31	24719451
385	Acetylation	GLAAYTAKMAAANGS CHHHHHHHHHHHCCC	22.67	7960907
401	Phosphorylation	KAERQKFSPY----- HHHHHCCCCC-----	30.26	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCBP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCBP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCBP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RN138_HUMAN	RNF138	physical	16713569
PCBP1_HUMAN	PCBP1	physical	23640898
PPID_HUMAN	PPID	physical	26186194
TRI11_HUMAN	TRIM11	physical	26186194
CSPG4_HUMAN	CSPG4	physical	26186194
PPID_HUMAN	PPID	physical	28514442
TRI11_HUMAN	TRIM11	physical	28514442
CSPG4_HUMAN	CSPG4	physical	28514442
DC1L2_HUMAN	DYNC1LI2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.