CELF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CELF3_HUMAN
• UniProt AC: Q5SZQ8
• Protein Name: CUGBP Elav-like family member 3
• Gene Name: CELF3
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA..
• Protein Sequence: MKEPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYTGLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAFVKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIALQFGAYSAYTQALMQQQAALVAAHSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSGTSTPPAIAATPVSAIPAALGVNGYSPVPTQPTGQPAPDALYPNGVHPYPAQSPAAPVDPLQQAYAGMQHYTAAYPAAYSLVAPAFPQPPALVAQQPPPPPQQQQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	HKGCAFLTYCARDSA CCCHHHHHHHHHHHH	15.31	30576142
55	Phosphorylation	KGCAFLTYCARDSAL CCHHHHHHHHHHHHH	6.05	22817900
60	Phosphorylation	LTYCARDSALKAQSA HHHHHHHHHHHHHHH	29.92	-
84	Ubiquitination	MNRPIQVKPADSESR CCCCCEECCCCCCCC	20.36	-
88	Phosphorylation	IQVKPADSESRGEDR CEECCCCCCCCCCCC	39.31	-
160	Phosphorylation	NTLHSSRTLPGASSS HHHHHCCCCCCCCCE	38.97	-
165	Phosphorylation	SRTLPGASSSLVVKF CCCCCCCCCEEEEEE	26.78	-
166	Phosphorylation	RTLPGASSSLVVKFA CCCCCCCCEEEEEEC	27.45	-
167	Phosphorylation	TLPGASSSLVVKFAD CCCCCCCEEEEEECC	23.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CELF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CELF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CELF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERG28_HUMAN	C14orf1	physical	16169070
SOBP_HUMAN	SOBP	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
CELF5_HUMAN	CELF5	physical	28514442
MKRN1_HUMAN	MKRN1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.