CELF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CELF5_HUMAN
• UniProt AC: Q8N6W0
• Protein Name: CUGBP Elav-like family member 5
• Gene Name: CELF5
• Organism: Homo sapiens (Human).
• Sequence Length: 485
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA..
• Protein Sequence: MARLTESEARRQQQQLLQPRPSPVGSSGPEPPGGQPDGMKDLDAIKLFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKGCAFLTYCARDSAIKAQTALHEQKTLPGMARPIQVKPADSESRGGRDRKLFVGMLNKQQSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAFVKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGILTPSLTLPFSPYSAYAQALMQQQTTVLSTSGSYLSPGVAFSPCHIQQIGAVSLNGLPATPIAPASGLHSPPLLGTTAVPGLVAPITNGFAGVVPFPGGHPALETVYANGLVPYPAQSPTVAETLHPAFSGVQQYTAMYPTAAITPIAHSVPQPPPLLQQQQREGPEGCNLFIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDPGHPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MARLTESEARRQ ---CCCCCHHHHHHH	31.73	29083192
7	Phosphorylation	-MARLTESEARRQQQ -CCCCCHHHHHHHHH	31.18	29083192
92	Phosphorylation	HKGCAFLTYCARDSA CCCCCHHHHHHHHHH	15.31	19835603
93	Phosphorylation	KGCAFLTYCARDSAI CCCCHHHHHHHHHHH	6.05	19835603
101	Ubiquitination	CARDSAIKAQTALHE HHHHHHHHHHHHHHH	33.87	29967540
104	Phosphorylation	DSAIKAQTALHEQKT HHHHHHHHHHHHCCC	35.73	19835603
110	Ubiquitination	QTALHEQKTLPGMAR HHHHHHCCCCCCCCC	49.39	30230243
122	Ubiquitination	MARPIQVKPADSESR CCCCCEEECCCCCCC	20.36	30230243
129	Dimethylation	KPADSESRGGRDRKL ECCCCCCCCCCCCHH	47.75	-
129	Methylation	KPADSESRGGRDRKL ECCCCCCCCCCCCHH	47.75	-
132	Dimethylation	DSESRGGRDRKLFVG CCCCCCCCCCHHHHH	43.30	-
132	Methylation	DSESRGGRDRKLFVG CCCCCCCCCCHHHHH	43.30	-
174	Ubiquitination	RGPDGSSKGCAFVKF ECCCCCCCCEEEEEE	60.76	29967540
387 (in isoform 2)	Phosphorylation	-	53.00	28450419
394 (in isoform 2)	Phosphorylation	-	46.64	28450419
396 (in isoform 2)	Phosphorylation	-	27.96	28450419
397 (in isoform 2)	Phosphorylation	-	30.01	28450419
398 (in isoform 2)	Phosphorylation	-	83.60	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CELF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CELF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CELF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUM2_HUMAN	PUM2	physical	28514442
SMAP2_HUMAN	SMAP2	physical	28514442
PAI2B_HUMAN	PAIP2B	physical	28514442
TNKS1_HUMAN	TNKS	physical	28514442
ATX2_HUMAN	ATXN2	physical	28514442
ERI3_HUMAN	ERI3	physical	28514442
PUM1_HUMAN	PUM1	physical	28514442
TNKS2_HUMAN	TNKS2	physical	28514442
SYIM_HUMAN	IARS2	physical	28514442
PAIP1_HUMAN	PAIP1	physical	28514442
ELAV2_HUMAN	ELAVL2	physical	28514442
CASC3_HUMAN	CASC3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.