SOBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOBP_HUMAN
• UniProt AC: A7XYQ1
• Protein Name: Sine oculis-binding protein homolog
• Gene Name: SOBP {ECO:0000312|EMBL:AAH91526.2}
• Organism: Homo sapiens (Human).
• Sequence Length: 873
• Protein Description: Implicated in development of the cochlea..
• Protein Sequence: MAEMEKEGRPPENKRSRKPAHPVKREINEEMKNFAENTMNELLGWYGYDKVELKDGEDIEFRSYPTDGESRQHISVLKENSLPKPKLPEDSVISPYNISTGYSGLATGNGLSDSPAGSKDHGSVPIIVPLIPPPFIKPPAEDDVSNVQIMCAWCQKVGIKRYSLSMGSEVKSFCSEKCFAACRRAYFKRNKARDEDGHAENFPQQHYAKETPRLAFKNNCELLVCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYKETQANLPAGLCSTLHPPMENKAEGTGVQLLTPDSWNIPLTDARRKAPSPVATAGQSQGPGPSASTTVSPSDTANCSVTKIPTPVPKSIPISETPNIPPVSVQPPASIGPPLGVPPRSPPMVMTNRGPVPLPIFMEQQIMQQIRPPFIRGPPHHASNPNSPLSNPMLPGIGPPPGGPRNLGPTSSPMHRPMLSPHIHPPSTPTMPGNPPGLLPPPPPGAPLPSLPFPPVSMMPNGPMPVPQMMNFGLPSLAPLVPPPTLLVPYPVIVPLPVPIPIPIPIPHVSDSKPPNGFSSNGENFIPNAPGDSAAAGGKPSGHSLSPRDSKQGSSKSADSPPGCSGQALSLAPTPAEHGRSEVVDLTRRAGSPPGPPGAGGQLGFPGVLQGPQDGVIDLTVGHRARLHNVIHRALHAHVKAEREPSAAERRTCGGCRDGHCSPPAAGDPGPGAPAGPEAAAACNVIVNGTRGAAAEGAKSAEPPPEQPPPPPPPAPPKKLLSPEEPAVSELESVKENNCASNCHLDGEAAKKLMGEEALAGGDKSDPNLNNPADEDHAYALRMLPKTGCVIQPVPKPAEKAAMAPCIISSPMLSAGPEDLEPPLKRRCLRIRNQNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	IEFRSYPTDGESRQH CEEEECCCCCCCHHH	48.69	26471730
70	Phosphorylation	SYPTDGESRQHISVL ECCCCCCCHHHEEEE	42.65	26471730
186	Phosphorylation	FAACRRAYFKRNKAR HHHHHHHHHHHHCCC	14.07	23532336
313	Phosphorylation	DARRKAPSPVATAGQ CHHHHCCCCCEECCC	36.54	26657352
317	Phosphorylation	KAPSPVATAGQSQGP HCCCCCEECCCCCCC	31.39	29116813
321	Phosphorylation	PVATAGQSQGPGPSA CCEECCCCCCCCCCC	35.87	29978859
327	Phosphorylation	QSQGPGPSASTTVSP CCCCCCCCCCCCCCH	40.54	29978859
329	Phosphorylation	QGPGPSASTTVSPSD CCCCCCCCCCCCHHH	29.02	29116813
330	Phosphorylation	GPGPSASTTVSPSDT CCCCCCCCCCCHHHC	30.82	29978859
331	Phosphorylation	PGPSASTTVSPSDTA CCCCCCCCCCHHHCC	19.25	29978859
333	Phosphorylation	PSASTTVSPSDTANC CCCCCCCCHHHCCCC	19.32	27486199
335	Phosphorylation	ASTTVSPSDTANCSV CCCCCCHHHCCCCEE	39.84	27486199
337	Phosphorylation	TTVSPSDTANCSVTK CCCCHHHCCCCEEEE	24.90	27486199
341	Phosphorylation	PSDTANCSVTKIPTP HHHCCCCEEEECCCC	32.40	27486199
343	Phosphorylation	DTANCSVTKIPTPVP HCCCCEEEECCCCCC	13.63	27486199
347	Phosphorylation	CSVTKIPTPVPKSIP CEEEECCCCCCCCCC	40.15	23312004
371	Phosphorylation	VSVQPPASIGPPLGV CCCCCCHHCCCCCCC	33.57	28348404
382	Phosphorylation	PLGVPPRSPPMVMTN CCCCCCCCCCEEECC	38.85	28348404
388	Phosphorylation	RSPPMVMTNRGPVPL CCCCEEECCCCCCCC	15.45	-
578	Phosphorylation	AAAGGKPSGHSLSPR CCCCCCCCCCCCCCC	53.26	27174698
581	Phosphorylation	GGKPSGHSLSPRDSK CCCCCCCCCCCCCCC	33.78	27174698
583	Phosphorylation	KPSGHSLSPRDSKQG CCCCCCCCCCCCCCC	22.39	27174698
594	Phosphorylation	SKQGSSKSADSPPGC CCCCCCCCCCCCCCC	38.98	30266825
597	Phosphorylation	GSSKSADSPPGCSGQ CCCCCCCCCCCCCCC	32.48	30266825
602	Phosphorylation	ADSPPGCSGQALSLA CCCCCCCCCCCEECC	39.59	30266825
607	Phosphorylation	GCSGQALSLAPTPAE CCCCCCEECCCCCHH	26.04	26074081
611	Phosphorylation	QALSLAPTPAEHGRS CCEECCCCCHHCCCH	29.53	26074081
618	Phosphorylation	TPAEHGRSEVVDLTR CCHHCCCHHHHHHHH	39.06	26074081
624	Phosphorylation	RSEVVDLTRRAGSPP CHHHHHHHHHCCCCC	17.41	26074081
629	Phosphorylation	DLTRRAGSPPGPPGA HHHHHCCCCCCCCCC	27.26	29255136
677	Sumoylation	RALHAHVKAEREPSA HHHHHHHHHHCCCCH	34.36	28112733
699	Phosphorylation	GCRDGHCSPPAAGDP CCCCCCCCCCCCCCC	28.39	26714015
759	Phosphorylation	APPKKLLSPEEPAVS CCCCCCCCCCCCCHH	40.47	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOBP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUMO2_HUMAN	SUMO2	physical	23086935

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.