ING2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ING2_HUMAN
• UniProt AC: Q9H160
• Protein Name: Inhibitor of growth protein 2
• Gene Name: ING2
• Organism: Homo sapiens (Human).
• Sequence Length: 280
• Subcellular Localization: Nucleus . Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
• Protein Description: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs)..
• Protein Sequence: MLGQQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDLNQKKRLQQLLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKAKMDSSQPERSSRRPRRQRTSESRDLCHMANGIEDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKDRRSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	GQQQQQLYSSAALLT HHHHHHHHHHHHHHH	9.02	21945579
11	Phosphorylation	QQQQQLYSSAALLTG HHHHHHHHHHHHHHC	23.30	21945579
12	Phosphorylation	QQQQLYSSAALLTGE HHHHHHHHHHHHHCC	12.19	21945579
17	Phosphorylation	YSSAALLTGERSRLL HHHHHHHHCCHHHHH	37.54	24719451
56	Phosphorylation	LRELDNKYQETLKEI HHHHHHHHHHHHHHH	20.17	20068231
59	Phosphorylation	LDNKYQETLKEIDDV HHHHHHHHHHHHHHH	27.83	20068231
61	Ubiquitination	NKYQETLKEIDDVYE HHHHHHHHHHHHHHH	61.10	-
69	Ubiquitination	EIDDVYEKYKKEDDL HHHHHHHHHHCCCCC	44.69	-
70	Phosphorylation	IDDVYEKYKKEDDLN HHHHHHHHHCCCCCH	18.49	-
93	Phosphorylation	LQRALINSQELGDEK HHHHHHCCHHHCHHH	20.31	26330541
143	Phosphorylation	DKAKMDSSQPERSSR HHHCCCCCCCHHHCC	45.55	23836654
157	Phosphorylation	RRPRRQRTSESRDLC CCCCHHCHHHHHHHH	28.62	28450419
158	Phosphorylation	RPRRQRTSESRDLCH CCCHHCHHHHHHHHH	35.45	24719451
160	Phosphorylation	RRQRTSESRDLCHMA CHHCHHHHHHHHHHH	30.75	28450419
195	Sumoylation	KKKRSKAKQEREASP HHHHHHHHHHHHCCC	57.33	20676127
217	Ubiquitination	NEPTYCLCNQVSYGE CCCCEEEECCEEHHH	2.74	-
257	Ubiquitination	KGKWYCPKCRGDNEK CCCEECCCCCCCCCC	32.76	-
264	Acetylation	KCRGDNEKTMDKSTE CCCCCCCCCCCHHHH	56.24	24849013
265	Phosphorylation	CRGDNEKTMDKSTEK CCCCCCCCCCHHHHH	25.15	28258704
275	Acetylation	KSTEKTKKDRRSR-- HHHHHHHHHHHCC--	62.79	24849023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20621832

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ING2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ING2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_HUMAN	SIN3A	physical	16387653
HDAC1_HUMAN	HDAC1	physical	16387653
HDAC2_HUMAN	HDAC2	physical	16387653
SDS3_HUMAN	SUDS3	physical	16387653
RBBP7_HUMAN	RBBP7	physical	16387653
RBBP4_HUMAN	RBBP4	physical	16387653
ARI4A_HUMAN	ARID4A	physical	16387653
ARI4B_HUMAN	ARID4B	physical	16387653
SP130_HUMAN	SAP130	physical	16387653
BRM1L_HUMAN	BRMS1L	physical	16387653
SAP30_HUMAN	SAP30	physical	16387653
SMRC2_HUMAN	SMARCC2	physical	16387653
SMRC1_HUMAN	SMARCC1	physical	16387653
ACL6A_HUMAN	ACTL6A	physical	16387653
SNF5_HUMAN	SMARCB1	physical	16387653
H3_YEAST	HHT1	physical	16728974
SAP30_YEAST	SAP30	physical	16728974
HDAC1_HUMAN	HDAC1	physical	16728974
SIN3A_HUMAN	SIN3A	physical	16728974
SKIL_HUMAN	SKIL	physical	18334480
SMAD2_HUMAN	SMAD2	physical	18334480
CSN2_HUMAN	COPS2	physical	17929852
SMUF1_HUMAN	SMURF1	physical	20621832
A4_HUMAN	APP	physical	21832049
SIN3B_HUMAN	SIN3B	physical	28514442
ARI4B_HUMAN	ARID4B	physical	28514442
SP130_HUMAN	SAP130	physical	28514442
HDAC1_HUMAN	HDAC1	physical	28514442
RBBP7_HUMAN	RBBP7	physical	28514442
CENPH_HUMAN	CENPH	physical	28514442
BRM1L_HUMAN	BRMS1L	physical	28514442
SDS3_HUMAN	SUDS3	physical	28514442
ARI4A_HUMAN	ARID4A	physical	28514442
SP30L_HUMAN	SAP30L	physical	28514442
SIN3A_HUMAN	SIN3A	physical	28514442
SYTC2_HUMAN	TARSL2	physical	28514442
BRMS1_HUMAN	BRMS1	physical	28514442
SAP30_HUMAN	SAP30	physical	28514442
BAHC1_HUMAN	BAHCC1	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442
AHNK_HUMAN	AHNAK	physical	28514442
HDAC2_HUMAN	HDAC2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.