dbPTM

BAHC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BAHC1_HUMAN
UniProt AC	Q9P281
Protein Name	BAH and coiled-coil domain-containing protein 1 {ECO:0000305}
Gene Name	BAHCC1 {ECO:0000312\|HGNC:HGNC:29279}
Organism	Homo sapiens (Human).
Sequence Length	2639
Subcellular Localization
Protein Description
Protein Sequence	MDGRDFAPPPHLLSERGSLGHRSAAAAARLAPAGPAAQPPAHFQPGKYFPSPLPMASHTASSRLMGSSPASSFMGSFLTSSLGSAASTHPSGPSSSPPEQAYRGSHPTTSQIWFSHSHEAPGYPRFSGSLASTFLPVSHLDHHGNSNVLYGQHRFYGTQKDNFYLRNLPPQPTLLPANHNFPSVARAAPAHPMGSCSRDRDRGEAGSLQKGPKDFDRFLVGKELGREKAGKAAEGKERPAAEEDGGKERHKLVLPVPADGHCREGGPAPRGACEGRPKHLTSCLLNTKVLNGEMGRAALASCAGGMLGRPGTGVVTSGRCAKEAAGPPEPGPAFSECLERRQMLHHTASYAGPPPPLSTAAGSFPCLQLHGGPDGLCPLQDKAPRDLKASGPTFVPSVGHLADKGRPFQAAEACAVAGEGKDRHLEGTMAPDHAAPYGVSYAHLKAEGKGERRPGGFEAALNPRLKGLDYLSSAGPEASFPGLPKSGLDKSGYFELPTSSQDCARPGHQDPLGGKAPQACCTLDKTVGKEAPAGPPGAQKVARIRHQQHLMAAEVEQGGIGAEAKRKSLELASLGYSGPHLPPWGVQAGQGTAMAISEERKAGAYLDPFGSGLQQAALLPQELPAPPDEVSAMKNLLKYSSQALVVGQKAPLVGLGGLKASCIQQEAKFLSSKGPGQSERPDCARSREHDTTHGDGEVRQPPVGIAVALARQKDTVSRSEAAYGTNTARQGRAAPAFKGGGGPRSTHALDLEAEEERTRLCDDRLGLASRELLLQDSKDRVEFARIHPPSSCPGDLAPHLMMQSGQLGGDPAPHTHPHPPWLPRTRSPSLWMGGHSYGLGHPALHQNLPPGFPASVAGPVPSVFPLPQDAPTQLVILPSEPTPHSAPHALADVMDQASLWPPMYGGRGPASHMQHPGQLPVYSRPQLLRQQELYALQQQRAAQFQRKPEDQHLDLEEPAQEKAPKSTHKPVALTPTAPGAPSPAAGPTKLPPCCHPPDPKPPASSPTPPPRPSAPCTLNVCPASSPGPGSRVRSAEEKNGEGQQSTADIITSEPVARAHSVAHAGLEFLASNDPSTSASQSFGITDLPPGYLRPMAGLGFSLPSDVHSSNLEDPETMQTTAPGAQPEPTRTFLPGEPPPCSPRSLEEPGLLSGAREATQDLAATPYPTERGPQGKAADPSPLEGLQELQCAALLEAGGPEATGQAHSTQGGAREERSREEGEQGPSSGASSQVLEQRAGSPGALEDEGEQPAPEEDELEEDELGQQSMEDSEEDCGGAPDNSHPPRALPGLDALVAATINLGDLPSDSPPDPQPPAASGPPSTVPLPHSSGIHGIALLSELADLAIQRQRSERTVPEEEEDVLAFNLQHLATLATAWSLVEAAGLDSSTAPAQPPTANPCSGPRLTPRMQILQRKDTWTPKTKPVCPLKAAIDRLDTQEVGMRVRLAELQRRYKEKQRELARLQRKHDHERDESSRSPARRGPGRPRKRKHSSSLPAPRPTGPLPRSDGKKVKAVRTSLGLLCAELRGGSGGEPAKKRSKLERSVYAGLQTASVEKAQCKKSSCQGGLAPSVAHRVAQLKPKVKSKGLPTGLSSFQQKEATPGGRIREKLSRAKSAKVSGATRHPQPKGHGSRETPRCPAQPSVAASQEAGSGYDSEDCEGLLGTEAPPREAGLLLHTGASVAVLGPSPSSVVKMEANQKAKKKKERQGLLGACRLSSPESEVKIKRRSVKAKVGTTLERAPGQRPPGALGKKKAKGKAKGSLRAEPGATPSRDALFNPSRAFACREEGSQLASERLKRATRKGTVLQPVLRRKNGALSITLATRNAKAILGKGRKLSKVKHKAGKQGKGRAVSRLLESFAVEEDFEFDDNSSFSEEEEDEEEEEEDSGPLSAEQSAALARSCAIHKEDLRDGLPVLIPKEDSLLYAGSVRTLQPPDIYSIVIEGERGNRQRIYSLEQLLQEAVLDVRPQSSRYLPPGTRVCAYWSQKSRCLYPGNVVRGASGDEDEDLDSVVVEFDDGDTGHIAVSNVRLLPPDFKIQCTEPSPALLVSSSCRRTKKVSSEAPPPSEAATPSLSPKAQDGPEALKTPGKKSISKDKAGKAELLTSGAKSPTGASDHFLGRRGSPLLSWSAVAQTKRKAVAAASKGPGVLQNLFQLNGSSKKLRAREALFPVHSVATPIFGNGFRADSFSSLASSYAPFVGGTGPGLPRGAHKLLRAKKAERVEAEKGGRRRAGGEFLVKLDHEGVTSPKNKTCKALLMGDKDFSPKLGRPLPSPSYVHPALVGKDKKGRAPIPPLPMGLALRKYAGQAEFPLPYDSDCHSSFSDEDEDGPGLAAGVPSRFLARLSVSSSSSGSSTSSSSGSVSTSSLCSSDNEDSSYSSDDEDPALLLQTCLTHPVPTLLAQPEALRSKGSGPHAHAQRCFLSRATVAGTGAGSGPSSSSKSKLKRKEALSFSKAKELSRRQRPPSVENRPKISAFLPARQLWKWSGNPTQRRGMKGKARKLFYKAIVRGEETLRVGDCAVFLSAGRPNLPYIGRIESMWESWGSNMVVKVKWFYHPEETKLGKRQCDGKNALYQSCHEDENDVQTISHKCQVVAREQYEQMARSRKCQDRQDLYYLAGTYDPTTGRLVTADGVPILC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	AHFQPGKYFPSPLPM CCCCCCCCCCCCCCC	27.00	25690035
94	Phosphorylation	STHPSGPSSSPPEQA CCCCCCCCCCCHHHH	47.15	30576142
95	Phosphorylation	THPSGPSSSPPEQAY CCCCCCCCCCHHHHH	50.42	30576142
173	Phosphorylation	RNLPPQPTLLPANHN CCCCCCCCCCCCCCC	35.36	22210691
222	Acetylation	FDRFLVGKELGREKA HHHHHHCHHHCHHHC	42.14	19608861
222	Ubiquitination	FDRFLVGKELGREKA HHHHHHCHHHCHHHC	42.14	29967540
228	Acetylation	GKELGREKAGKAAEG CHHHCHHHCHHHHCC	62.16	11922879
236	Acetylation	AGKAAEGKERPAAEE CHHHHCCCCCCCCCC	41.89	11922889
301	Phosphorylation	MGRAALASCAGGMLG HHHHHHHHHHCCCCC	12.83	23532336
317	Phosphorylation	PGTGVVTSGRCAKEA CCCCEEECCCCHHHH	16.78	23532336
319	Dimethylation	TGVVTSGRCAKEAAG CCEEECCCCHHHHCC	19.58	-
388	Ubiquitination	DKAPRDLKASGPTFV CCCCCCHHHCCCCCC	44.81	29967540
421	Ubiquitination	CAVAGEGKDRHLEGT HHHCCCCCCCCCCCC	47.49	29967540
466	Ubiquitination	AALNPRLKGLDYLSS HHHCHHHCCHHHHHH	59.72	29967540
485	Ubiquitination	ASFPGLPKSGLDKSG CCCCCCCCCCCCCCC	63.30	29967540
540	Ubiquitination	AGPPGAQKVARIRHQ CCCCCHHHHHHHHHH	37.01	29967540
638	Acetylation	SAMKNLLKYSSQALV HHHHHHHHHHCCEEE	46.37	7675715
649	Acetylation	QALVVGQKAPLVGLG CEEECCCCCCCCCCC	46.15	7675725
659	Ubiquitination	LVGLGGLKASCIQQE CCCCCHHHHHHHHHH	41.34	29967540
673	Ubiquitination	EAKFLSSKGPGQSER HHHHHHCCCCCCCCC	66.79	29967540
686	O-linked_Glycosylation	ERPDCARSREHDTTH CCCCHHHCCCCCCCC	24.40	30379171
744	Dimethylation	FKGGGGPRSTHALDL CCCCCCCCCCCCCCC	58.42	-
745	Phosphorylation	KGGGGPRSTHALDLE CCCCCCCCCCCCCCC	27.90	24719451
746	Phosphorylation	GGGGPRSTHALDLEA CCCCCCCCCCCCCCH	16.67	24719451
824	Methylation	PHPPWLPRTRSPSLW CCCCCCCCCCCCCCC	40.37	-
826	Methylation	PPWLPRTRSPSLWMG CCCCCCCCCCCCCCC	48.10	-
885	Phosphorylation	PSEPTPHSAPHALAD CCCCCCCCCCCHHHH	44.70	28787133
966	Phosphorylation	AQEKAPKSTHKPVAL HHHHCCCCCCCCCEE	34.38	26074081
967	Phosphorylation	QEKAPKSTHKPVALT HHHCCCCCCCCCEEC	39.79	26074081
969	Acetylation	KAPKSTHKPVALTPT HCCCCCCCCCEECCC	41.08	26051181
974	Phosphorylation	THKPVALTPTAPGAP CCCCCEECCCCCCCC	14.62	26074081
976	Phosphorylation	KPVALTPTAPGAPSP CCCEECCCCCCCCCC	40.00	26074081
982	Phosphorylation	PTAPGAPSPAAGPTK CCCCCCCCCCCCCCC	27.00	26074081
988	Phosphorylation	PSPAAGPTKLPPCCH CCCCCCCCCCCCCCC	44.27	26074081
1100	Phosphorylation	RPMAGLGFSLPSDVH CCCCCCCCCCCCCCC	31.81	27251275
1110	Phosphorylation	PSDVHSSNLEDPETM CCCCCCCCCCCCCHH	29.17	21130716
1113	Phosphorylation	VHSSNLEDPETMQTT CCCCCCCCCCHHCCC	43.44	26074081
1200	Phosphorylation	LLEAGGPEATGQAHS HHHCCCCCCCCCCCC	24.63	17525332
1209	Phosphorylation	TGQAHSTQGGAREER CCCCCCCCCCCCCHH	21.12	-
1236	Phosphorylation	ASSQVLEQRAGSPGA HHHHHHHHHCCCCCC	19.09	24275569
1240	Phosphorylation	VLEQRAGSPGALEDE HHHHHCCCCCCCCCC	29.58	24275569
1251	Phosphorylation	LEDEGEQPAPEEDEL CCCCCCCCCCCCCCC	44.76	-
1386	Phosphorylation	LVEAAGLDSSTAPAQ HHHHCCCCCCCCCCC	33.98	24719451
1391	Phosphorylation	GLDSSTAPAQPPTAN CCCCCCCCCCCCCCC	41.61	24719451
1443	Phosphorylation	DTQEVGMRVRLAELQ CHHHHHHHHHHHHHH	35.03	-
1444	Phosphorylation	TQEVGMRVRLAELQR HHHHHHHHHHHHHHH	34.43	-
1461	Phosphorylation	KEKQRELARLQRKHD HHHHHHHHHHHHHCH	25.34	28152594
1462	Phosphorylation	EKQRELARLQRKHDH HHHHHHHHHHHHCHH	35.30	22210691
1463	Phosphorylation	KQRELARLQRKHDHE HHHHHHHHHHHCHHH	41.19	22210691
1479	Acetylation	DESSRSPARRGPGRP CHHCCCCCCCCCCCC	60.42	-
1522	Phosphorylation	VRTSLGLLCAELRGG HHHHHHHHHHHHCCC	33.91	24719451
1531	Phosphorylation	AELRGGSGGEPAKKR HHHCCCCCCCCCHHH	23.11	23312004
1532	Phosphorylation	ELRGGSGGEPAKKRS HHCCCCCCCCCHHHH	21.24	23312004
1540	Phosphorylation	EPAKKRSKLERSVYA CCCHHHHHHHHHHHH	26.74	23312004
1604	Phosphorylation	QKEATPGGRIREKLS HCCCCCCHHHHHHHH	18.21	-
1623	Phosphorylation	AKVSGATRHPQPKGH CCCCCCCCCCCCCCC	21.94	-
1654	Phosphorylation	SQEAGSGYDSEDCEG HCCCCCCCCHHHCCC	6.35	-
1686	Phosphorylation	GASVAVLGPSPSSVV CCEEEEECCCHHHHH	25.21	21949786
1687	Phosphorylation	ASVAVLGPSPSSVVK CEEEEECCCHHHHHH	36.96	25850435
1690	Phosphorylation	AVLGPSPSSVVKMEA EEECCCHHHHHHHHH	51.58	21949786
1739	Phosphorylation	AKVGTTLERAPGQRP HHCCCCHHCCCCCCC	27.93	27050516
1759	Phosphorylation	KKKAKGKAKGSLRAE CCCCCCCCCCCCCCC	25.87	23403867
1763	Phosphorylation	KGKAKGSLRAEPGAT CCCCCCCCCCCCCCC	31.66	24719451
2013	Phosphorylation	DEDLDSVVVEFDDGD CCCCCEEEEEECCCC	19.30	25627689
2025	Phosphorylation	DGDTGHIAVSNVRLL CCCCCEEEEEEEEEC	18.83	-
2029	Phosphorylation	GHIAVSNVRLLPPDF CEEEEEEEEECCCCC	31.19	-
2030	Phosphorylation	HIAVSNVRLLPPDFK EEEEEEEEECCCCCE	40.54	-
2036	Phosphorylation	VRLLPPDFKIQCTEP EEECCCCCEEEECCC	45.71	29255136
2040	Phosphorylation	PPDFKIQCTEPSPAL CCCCEEEECCCCCCE	22.06	29255136
2042	Phosphorylation	DFKIQCTEPSPALLV CCEEEECCCCCCEEE	36.80	29255136
2044	Phosphorylation	KIQCTEPSPALLVSS EEEECCCCCCEEEEC	28.79	29255136
2056	Phosphorylation	VSSSCRRTKKVSSEA EECCCCCCCCCCCCC	37.82	28985074
2063	Phosphorylation	TKKVSSEAPPPSEAA CCCCCCCCCCCHHCC	41.72	-
2074	Phosphorylation	SEAATPSLSPKAQDG HHCCCCCCCCCCCCC	37.43	28450419
2075	Phosphorylation	EAATPSLSPKAQDGP HCCCCCCCCCCCCCH	36.40	28450419
2079	Phosphorylation	PSLSPKAQDGPEALK CCCCCCCCCCHHHHC	27.45	23401153
2081	Phosphorylation	LSPKAQDGPEALKTP CCCCCCCCHHHHCCC	53.09	29255136
2084	Phosphorylation	KAQDGPEALKTPGKK CCCCCHHHHCCCCCC	32.72	21949786
2093	Phosphorylation	KTPGKKSISKDKAGK CCCCCCCCCCCCCCC	15.57	28450419
2097	Phosphorylation	KKSISKDKAGKAELL CCCCCCCCCCCEEHH	27.03	28450419
2113	Phosphorylation	SGAKSPTGASDHFLG CCCCCCCCCCCCCCC	33.16	23612710
2146	Phosphorylation	AVAAASKGPGVLQNL HHHHHHCCHHHHHHH	18.11	-
2216	Phosphorylation	RGAHKLLRAKKAERV HHHHHHHHHHHHHHH	50.60	30266825
2217	Phosphorylation	GAHKLLRAKKAERVE HHHHHHHHHHHHHHH	31.32	23401153
2234	Phosphorylation	KGGRRRAGGEFLVKL CCCCCCCCCCEEEEC	31.12	24719451
2243	Phosphorylation	EFLVKLDHEGVTSPK CEEEECCCCCCCCCC	33.87	28450419
2245	Phosphorylation	LVKLDHEGVTSPKNK EEECCCCCCCCCCCC	44.09	28450419
2246	Phosphorylation	VKLDHEGVTSPKNKT EECCCCCCCCCCCCC	13.23	29978859
2274	Phosphorylation	KLGRPLPSPSYVHPA CCCCCCCCCCCCCHH	14.99	23186163
2400	Phosphorylation	LTHPVPTLLAQPEAL HHCCCCHHHHCHHHH	17.70	24505115
2404	Phosphorylation	VPTLLAQPEALRSKG CCHHHHCHHHHHCCC	47.17	25627689
2410	Phosphorylation	QPEALRSKGSGPHAH CHHHHHCCCCCCCHH	42.78	24505115
2417	Acetylation	KGSGPHAHAQRCFLS CCCCCCHHHHHHHHC	45.83	-
2421	Phosphorylation	PHAHAQRCFLSRATV CCHHHHHHHHCCCEE	34.22	24719451
2436	Phosphorylation	AGTGAGSGPSSSSKS CCCCCCCCCCCCCHH	44.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BAHC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BAHC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BAHC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
COMD1_HUMAN	COMMD1	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BAHC1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-222, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1200, AND MASSSPECTROMETRY.	17525332 [Abstract]