| UniProt ID | SKIL_HUMAN | |
|---|---|---|
| UniProt AC | P12757 | |
| Protein Name | Ski-like protein | |
| Gene Name | SKIL | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 684 | |
| Subcellular Localization | ||
| Protein Description | May have regulatory role in cell division or differentiation in response to extracellular signals.. | |
| Protein Sequence | MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MENLQTNFSLVQG --CCCCHHCCEEEEC | 41.20 | 29759185 | |
| 9 | Phosphorylation | ENLQTNFSLVQGSTK CCCHHCCEEEECCCC | 29.69 | 29759185 | |
| 14 | Phosphorylation | NFSLVQGSTKKLNGM CCEEEECCCCCCCCC | 21.69 | 29759185 | |
| 15 | Phosphorylation | FSLVQGSTKKLNGMG CEEEECCCCCCCCCC | 38.74 | 29759185 | |
| 26 | Phosphorylation | NGMGDDGSPPAKKMI CCCCCCCCCCHHHHC | 34.40 | 21815630 | |
| 50 | Ubiquitination | INKVPTVKKEHLDDY ECCCCCCCHHHCCCC | 55.72 | 32015554 | |
| 50 | Sumoylation | INKVPTVKKEHLDDY ECCCCCCCHHHCCCC | 55.72 | 25755297 | |
| 50 | Sumoylation | INKVPTVKKEHLDDY ECCCCCCCHHHCCCC | 55.72 | - | |
| 70 | Sumoylation | ETDGEHVKRTCTSVP CCCCHHHHCCCCCCC | 43.85 | 28112733 | |
| 70 | Ubiquitination | ETDGEHVKRTCTSVP CCCCHHHHCCCCCCC | 43.85 | 32015554 | |
| 229 | Ubiquitination | TLTDAQRLCNALLRP EHHHHHHHHHHHHCC | 1.43 | 21890473 | |
| 229 | Ubiquitination | TLTDAQRLCNALLRP EHHHHHHHHHHHHCC | 1.43 | 21890473 | |
| 236 | Ubiquitination | LCNALLRPRTFPQNG HHHHHHCCCCCCCCC | 39.36 | 32015554 | |
| 249 | Ubiquitination | NGSVLPAKSSLAQLK CCCCCCCCCHHHHHH | 38.34 | 21890473 | |
| 249 (in isoform 1) | Ubiquitination | - | 38.34 | 21890473 | |
| 249 (in isoform 2) | Ubiquitination | - | 38.34 | 21890473 | |
| 249 (in isoform 3) | Ubiquitination | - | 38.34 | 21890473 | |
| 249 (in isoform 4) | Ubiquitination | - | 38.34 | 21890473 | |
| 256 | Ubiquitination | KSSLAQLKETGSAFE CCHHHHHHHHCCCEE | 40.94 | 32015554 | |
| 322 | Ubiquitination | TCHWGFESAKWHCYL CCCCCHHHCCEEEEE | 32.65 | 33845483 | |
| 342 | Ubiquitination | YLGTPEEKKLKIILE HCCCCHHHHHHHHHH | 62.84 | 33845483 | |
| 383 | Sumoylation | QSWYPVIKQEGDHVS HHHHCEEEECCCCCC | 42.40 | - | |
| 383 | Sumoylation | QSWYPVIKQEGDHVS HHHHCEEEECCCCCC | 42.40 | - | |
| 392 | Phosphorylation | EGDHVSQTHSFLHPS CCCCCCCCHHCCCHH | 16.39 | 30576142 | |
| 399 | Phosphorylation | THSFLHPSYYLYMCD CHHCCCHHHHHEECC | 18.70 | 30576142 | |
| 403 | Ubiquitination | LHPSYYLYMCDKVVA CCHHHHHEECCCEEC | 4.60 | 21890473 | |
| 403 | Ubiquitination | LHPSYYLYMCDKVVA CCHHHHHEECCCEEC | 4.60 | 21890473 | |
| 407 | Ubiquitination | YYLYMCDKVVAPNVS HHHEECCCEECCCCC | 33.41 | 33845483 | |
| 420 | Ubiquitination | VSLTSAVSQSKELTK CCHHHHHHCCCCCCH | 28.58 | 22817900 | |
| 423 (in isoform 1) | Ubiquitination | - | 49.45 | 21890473 | |
| 423 | Ubiquitination | TSAVSQSKELTKTEA HHHHHCCCCCCHHHH | 49.45 | 22817900 | |
| 423 (in isoform 3) | Ubiquitination | - | 49.45 | 21890473 | |
| 423 (in isoform 4) | Ubiquitination | - | 49.45 | 21890473 | |
| 426 | Phosphorylation | VSQSKELTKTEASKS HHCCCCCCHHHHHHH | 36.69 | 20068231 | |
| 426 | Ubiquitination | VSQSKELTKTEASKS HHCCCCCCHHHHHHH | 36.69 | 22817900 | |
| 427 | Ubiquitination | SQSKELTKTEASKSI HCCCCCCHHHHHHHH | 57.92 | 33845483 | |
| 428 | Phosphorylation | QSKELTKTEASKSIS CCCCCCHHHHHHHHH | 31.39 | 20068231 | |
| 428 (in isoform 3) | Phosphorylation | - | 31.39 | 26437602 | |
| 429 | Ubiquitination | SKELTKTEASKSISR CCCCCHHHHHHHHHH | 53.13 | 33845483 | |
| 431 | Phosphorylation | ELTKTEASKSISRQS CCCHHHHHHHHHHHH | 22.24 | 29978859 | |
| 432 | Acetylation | LTKTEASKSISRQSE CCHHHHHHHHHHHHH | 59.88 | 12655533 | |
| 433 | Phosphorylation | TKTEASKSISRQSEK CHHHHHHHHHHHHHH | 24.25 | 29978859 | |
| 435 | Phosphorylation | TEASKSISRQSEKAH HHHHHHHHHHHHHHH | 31.21 | 29978859 | |
| 440 | Acetylation | SISRQSEKAHSSGKL HHHHHHHHHHHCCCC | 57.56 | 12655409 | |
| 440 | Ubiquitination | SISRQSEKAHSSGKL HHHHHHHHHHHCCCC | 57.56 | 22817900 | |
| 446 | Ubiquitination | EKAHSSGKLQKTVSY HHHHHCCCCCCCCCC | 50.09 | 22817900 | |
| 447 | Ubiquitination | KAHSSGKLQKTVSYP HHHHCCCCCCCCCCC | 7.82 | 33845483 | |
| 449 | Ubiquitination | HSSGKLQKTVSYPDV HHCCCCCCCCCCCCC | 62.42 | 22817900 | |
| 450 | Phosphorylation | SSGKLQKTVSYPDVS HCCCCCCCCCCCCCC | 11.17 | 30108239 | |
| 452 | Phosphorylation | GKLQKTVSYPDVSLE CCCCCCCCCCCCCHH | 35.86 | 25159151 | |
| 453 | Phosphorylation | KLQKTVSYPDVSLEE CCCCCCCCCCCCHHH | 10.10 | 30108239 | |
| 457 | Ubiquitination | TVSYPDVSLEEQEKM CCCCCCCCHHHHHHC | 37.13 | 33845483 | |
| 457 | Phosphorylation | TVSYPDVSLEEQEKM CCCCCCCCHHHHHHC | 37.13 | 25159151 | |
| 463 | Acetylation | VSLEEQEKMDLKTSR CCHHHHHHCCHHHHH | 37.09 | 7978537 | |
| 467 | Ubiquitination | EQEKMDLKTSRELCS HHHHCCHHHHHHHHH | 39.94 | 33845483 | |
| 473 | Ubiquitination | LKTSRELCSRLDASI HHHHHHHHHHHHHHH | 1.58 | 32015554 | |
| 483 | Ubiquitination | LDASISNNSTSKRKS HHHHHCCCCCCCCCC | 39.61 | 33845483 | |
| 484 | Phosphorylation | DASISNNSTSKRKSE HHHHCCCCCCCCCCC | 38.00 | 25627689 | |
| 486 | Phosphorylation | SISNNSTSKRKSESA HHCCCCCCCCCCCCH | 30.22 | 25627689 | |
| 487 | Methylation | ISNNSTSKRKSESAT HCCCCCCCCCCCCHH | 65.03 | 115981155 | |
| 487 | Ubiquitination | ISNNSTSKRKSESAT HCCCCCCCCCCCCHH | 65.03 | 33845483 | |
| 489 | Sumoylation | NNSTSKRKSESATCN CCCCCCCCCCCHHHH | 63.41 | - | |
| 489 | Sumoylation | NNSTSKRKSESATCN CCCCCCCCCCCHHHH | 63.41 | 28112733 | |
| 490 | Phosphorylation | NSTSKRKSESATCNL CCCCCCCCCCHHHHH | 40.59 | 21815630 | |
| 492 | Phosphorylation | TSKRKSESATCNLVR CCCCCCCCHHHHHHH | 35.65 | 25627689 | |
| 494 | Ubiquitination | KRKSESATCNLVRDI CCCCCCHHHHHHHCH | 15.94 | 29967540 | |
| 499 | Ubiquitination | SATCNLVRDINKVGI CHHHHHHHCHHHHCH | 42.11 | 32015554 | |
| 503 | Ubiquitination | NLVRDINKVGIGLVA HHHHCHHHHCHHHHH | 42.02 | 33845483 | |
| 505 (in isoform 4) | Ubiquitination | - | 15.17 | 21890473 | |
| 505 | Ubiquitination | VRDINKVGIGLVAAA HHCHHHHCHHHHHHC | 15.17 | 21890473 | |
| 506 (in isoform 3) | Ubiquitination | - | 4.28 | 21890473 | |
| 506 | Ubiquitination | RDINKVGIGLVAAAS HCHHHHCHHHHHHCC | 4.28 | 29967540 | |
| 509 | Ubiquitination | NKVGIGLVAAASSPL HHHCHHHHHHCCCCE | 2.62 | 32015554 | |
| 513 | Phosphorylation | IGLVAAASSPLLVKD HHHHHHCCCCEEEEE | 27.97 | 29255136 | |
| 514 | Phosphorylation | GLVAAASSPLLVKDV HHHHHCCCCEEEEEE | 18.16 | 29255136 | |
| 519 | Ubiquitination | ASSPLLVKDVICEDD CCCCEEEEEEECCCC | 46.37 | 32015554 | |
| 520 | Ubiquitination | SSPLLVKDVICEDDK CCCEEEEEEECCCCC | 27.77 | 29967540 | |
| 527 | Sumoylation | DVICEDDKGKIMEEV EEECCCCCCHHHHHH | 74.54 | - | |
| 527 | Sumoylation | DVICEDDKGKIMEEV EEECCCCCCHHHHHH | 74.54 | 28112733 | |
| 529 | Ubiquitination | ICEDDKGKIMEEVMR ECCCCCCHHHHHHHH | 44.62 | 32015554 | |
| 531 | Ubiquitination | EDDKGKIMEEVMRTY CCCCCHHHHHHHHHH | 4.02 | 21890473 | |
| 531 | Ubiquitination | EDDKGKIMEEVMRTY CCCCCHHHHHHHHHH | 4.02 | 21890473 | |
| 532 | Ubiquitination | DDKGKIMEEVMRTYL CCCCHHHHHHHHHHH | 51.41 | 29967540 | |
| 534 | Ubiquitination | KGKIMEEVMRTYLKQ CCHHHHHHHHHHHHH | 1.68 | 29967540 | |
| 540 | Ubiquitination | EVMRTYLKQQEKLNL HHHHHHHHHHHHHHH | 39.25 | 29967540 | |
| 551 (in isoform 1) | Ubiquitination | - | 49.45 | 21890473 | |
| 551 | Ubiquitination | KLNLILQKKQQLQME HHHHHHHHHHHHHHH | 49.45 | 21890473 | |
| 552 | Ubiquitination | LNLILQKKQQLQMEV HHHHHHHHHHHHHHH | 30.25 | 29967540 | |
| 555 | Ubiquitination | ILQKKQQLQMEVKML HHHHHHHHHHHHHHH | 4.92 | 33845483 | |
| 560 | Ubiquitination | QQLQMEVKMLSSSKS HHHHHHHHHHHCCHH | 22.33 | 29967540 | |
| 566 | Ubiquitination | VKMLSSSKSMKELTE HHHHHCCHHHHHHHH | 57.42 | 29967540 | |
| 579 | Ubiquitination | TEEQQNLQKELESLQ HHHHHHHHHHHHHHH | 44.73 | 33845483 | |
| 580 | Ubiquitination | EEQQNLQKELESLQN HHHHHHHHHHHHHHH | 68.39 | 29967540 | |
| 581 | Ubiquitination | EQQNLQKELESLQNE HHHHHHHHHHHHHHH | 44.82 | 33845483 | |
| 592 | Ubiquitination | LQNEHAQRMEEFYVE HHHHHHHHHHHHHHH | 34.95 | 29967540 | |
| 601 | Ubiquitination | EEFYVEQKDLEKKLE HHHHHHHHHHHHHHH | 51.26 | 33845483 | |
| 605 | Ubiquitination | VEQKDLEKKLEQIMK HHHHHHHHHHHHHHH | 70.70 | 33845483 | |
| 612 | Ubiquitination | KKLEQIMKQKCTCDS HHHHHHHHCCCCCCC | 48.51 | 29967540 | |
| 625 | Ubiquitination | DSNLEKDKEAEYAGQ CCCCHHHHHHHHHHH | 70.64 | 33845483 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| - | K | Ubiquitination | E3 ubiquitin ligase | RNF111 | Q6ZNA4 | PMID:17510063 |
| - | K | Ubiquitination | E3 ubiquitin ligase | SMURF2 | Q9HAU4 | PMID:11389444 |
| - | K | Ubiquitination | E3 ubiquitin ligase | FZR1 | Q9UM11 | PMID:11741538 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SKIL_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SKIL_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND MASSSPECTROMETRY. | |
