| UniProt ID | TFPI2_HUMAN | |
|---|---|---|
| UniProt AC | P48307 | |
| Protein Name | Tissue factor pathway inhibitor 2 | |
| Gene Name | TFPI2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 235 | |
| Subcellular Localization | Secreted. | |
| Protein Description | May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.. | |
| Protein Sequence | MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIRKIRKKQF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 57 | Phosphorylation | LRYYYDRYTQSCRQF HHHHHHHHCHHHHHH | 13.26 | - | |
| 77 | Phosphorylation | EGNANNFYTWEACDD CCCCCCCCCHHHCCH | 17.05 | - | |
| 101 | Phosphorylation | KVCRLQVSVDDQCEG CEEEEEEEECCCCCC | 13.58 | 29507054 | |
| 110 | Phosphorylation | DDQCEGSTEKYFFNL CCCCCCCCEEEEEEH | 47.56 | 30631047 | |
| 116 | N-linked_Glycosylation | STEKYFFNLSSMTCE CCEEEEEEHHHCCHH | 29.16 | UniProtKB CARBOHYD | |
| 152 | 2-Hydroxyisobutyrylation | CMGFCAPKKIPSFCY CCCEECCCCCCCCCC | 44.82 | - | |
| 168 | Phosphorylation | PKDEGLCSANVTRYY CCCCCCCCCCCEEEE | 28.11 | 22777824 | |
| 170 | N-linked_Glycosylation | DEGLCSANVTRYYFN CCCCCCCCCEEEECC | 21.28 | UniProtKB CARBOHYD | |
| 172 | Phosphorylation | GLCSANVTRYYFNPR CCCCCCCEEEECCCC | 16.86 | 29514088 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TFPI2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TFPI2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TFPI2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TFPI2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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