dbPTM

HEY1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HEY1_HUMAN
UniProt AC	Q9Y5J3
Protein Name	Hairy/enhancer-of-split related with YRPW motif protein 1
Gene Name	HEY1
Organism	Homo sapiens (Human).
Sequence Length	304
Subcellular Localization	Nucleus .
Protein Description	Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. [PubMed: 11095750 Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3]
Protein Sequence	MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MKRAHPEYSSSDSEL CCCCCCCCCCCCHHH	20.50	20363803
9	Phosphorylation	KRAHPEYSSSDSELD CCCCCCCCCCCHHHH	23.00	20363803
10	Phosphorylation	RAHPEYSSSDSELDE CCCCCCCCCCHHHHH	36.94	20363803
11	Phosphorylation	AHPEYSSSDSELDET CCCCCCCCCHHHHHC	38.93	20363803
13	Phosphorylation	PEYSSSDSELDETIE CCCCCCCHHHHHCEE	41.84	20363803
25	Phosphorylation	TIEVEKESADENGNL CEEEEHHHCCCCCCH	52.68	19413330
34	Phosphorylation	DENGNLSSALGSMSP CCCCCHHHHHHCCCC	30.58	22210691
38	Phosphorylation	NLSSALGSMSPTTSS CHHHHHHCCCCCCHH	19.55	22210691
40	Phosphorylation	SSALGSMSPTTSSQI HHHHHCCCCCCHHHH	22.31	28348404
42	Phosphorylation	ALGSMSPTTSSQILA HHHCCCCCCHHHHHH	31.81	29449344
43	Phosphorylation	LGSMSPTTSSQILAR HHCCCCCCHHHHHHH	29.75	29449344
44	Phosphorylation	GSMSPTTSSQILARK HCCCCCCHHHHHHHH	23.79	29449344
45	Phosphorylation	SMSPTTSSQILARKR CCCCCCHHHHHHHHH	21.10	22210691
59	Acetylation	RRRGIIEKRRRDRIN HHCCHHHHHHHHHHH	40.57	30589147
78	Phosphorylation	ELRRLVPSAFEKQGS HHHHHCHHHHHHHCC	37.80	24719451
97	Phosphorylation	KAEILQMTVDHLKML HHHHHHHHHHHHHHH	15.15	-
161	Phosphorylation	LVSHLNNYASQREAA HHHHHHHHHHHHHHH	13.42	23911959
163	Phosphorylation	SHLNNYASQREAASG HHHHHHHHHHHHHCC	21.29	23911959

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ORF50	O92608	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HEY1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HEY1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYOD1_HUMAN	MYOD1	physical	11279181
NOTC1_HUMAN	NOTCH1	genetic	18239137
SE1L1_HUMAN	SEL1L	physical	24366871
SYVN1_HUMAN	SYVN1	physical	24366871
HEY2_HUMAN	HEY2	physical	24366871
DERL2_HUMAN	DERL2	physical	24366871
HES1_HUMAN	HES1	physical	26068074
MYCB2_HUMAN	MYCBP2	physical	26068074
FBSP1_HUMAN	FBXO45	physical	26068074
SKP1_HUMAN	SKP1	physical	26068074
DPF3_HUMAN	DPF3	physical	26582913
TLE1_HUMAN	TLE1	physical	19321451
HEY1_HUMAN	HEY1	physical	19802006
HES1_HUMAN	HES1	physical	19802006
HEY2_HUMAN	HEY2	physical	19802006
HES1_HUMAN	HES1	physical	27129302
HEY2_HUMAN	HEY2	physical	27129302
P53_HUMAN	TP53	physical	27129302
STK38_HUMAN	STK38	physical	27129302
ST38L_HUMAN	STK38L	physical	27129302
RL11_HUMAN	RPL11	physical	27129302
MDM2_HUMAN	MDM2	physical	27129302
NONO_HUMAN	NONO	physical	27129302
CSK2B_HUMAN	CSNK2B	physical	27129302
MARK3_HUMAN	MARK3	physical	27129302
TBA1B_HUMAN	TUBA1B	physical	27129302
TBB4B_HUMAN	TUBB4B	physical	27129302
TBA1A_HUMAN	TUBA1A	physical	27129302
TBB2A_HUMAN	TUBB2A	physical	27129302
TBB5_HUMAN	TUBB	physical	27129302
TBB3_HUMAN	TUBB3	physical	27129302
TBA4A_HUMAN	TUBA4A	physical	27129302
TBB4A_HUMAN	TUBB4A	physical	27129302
FLNA_HUMAN	FLNA	physical	27129302
ACTB_HUMAN	ACTB	physical	27129302
VIME_HUMAN	VIM	physical	27129302
HSP7C_HUMAN	HSPA8	physical	27129302
GRP78_HUMAN	HSPA5	physical	27129302
HS90B_HUMAN	HSP90AB1	physical	27129302
TCPE_HUMAN	CCT5	physical	27129302
TCPZ_HUMAN	CCT6A	physical	27129302
TCPQ_HUMAN	CCT8	physical	27129302
CCD78_HUMAN	CCDC78	physical	27129302
GRDN_HUMAN	CCDC88A	physical	27129302
CC124_HUMAN	CCDC124	physical	27129302
TMA7_HUMAN	TMA7	physical	27129302
TITIN_HUMAN	TTN	physical	27129302
SYNE1_HUMAN	SYNE1	physical	27129302
SYNE2_HUMAN	SYNE2	physical	27129302
TNKS1_HUMAN	TNKS	physical	27129302
TB182_HUMAN	TNKS1BP1	physical	27129302
AKAP9_HUMAN	AKAP9	physical	27129302
TERA_HUMAN	VCP	physical	27129302
PLEC_HUMAN	PLEC	physical	27129302
EWS_HUMAN	EWSR1	physical	27129302
CSK21_HUMAN	CSNK2A1	physical	27129302
M18BP_HUMAN	MIS18BP1	physical	27129302
PTN13_HUMAN	PTPN13	physical	27129302
RAB1A_HUMAN	RAB1A	physical	27129302
APC_HUMAN	APC	physical	27129302
DCTN1_HUMAN	DCTN1	physical	27129302
FMNL1_HUMAN	FMNL1	physical	27129302
CDC6_HUMAN	CDC6	physical	27129302
BIRC6_HUMAN	BIRC6	physical	27129302
PAF15_HUMAN	KIAA0101	physical	27129302
RL8_HUMAN	RPL8	physical	27129302
RS10_HUMAN	RPS10	physical	27129302
RS25_HUMAN	RPS25	physical	27129302
HNRPK_HUMAN	HNRNPK	physical	27129302
RS19_HUMAN	RPS19	physical	27129302
RS7_HUMAN	RPS7	physical	27129302
RL15_HUMAN	RPL15	physical	27129302
RS16_HUMAN	RPS16	physical	27129302
RS18_HUMAN	RPS18	physical	27129302
RL12_HUMAN	RPL12	physical	27129302
RS14_HUMAN	RPS14	physical	27129302
RL23_HUMAN	RPL23	physical	27129302
RS3_HUMAN	RPS3	physical	27129302
RS29_HUMAN	RPS29	physical	27129302
RS20_HUMAN	RPS20	physical	27129302
RL9_HUMAN	RPL9	physical	27129302
ROA1_HUMAN	HNRNPA1	physical	27129302
SMD1_HUMAN	SNRPD1	physical	27129302
SMD3_HUMAN	SNRPD3	physical	27129302
RL22L_HUMAN	RPL22L1	physical	27129302
RSMB_HUMAN	SNRPB	physical	27129302
RS17_HUMAN	RPS17	physical	27129302
SNR27_HUMAN	SNRNP27	physical	27129302
RS5_HUMAN	RPS5	physical	27129302
UBIM_HUMAN	FAU	physical	27129302
HNRH1_HUMAN	HNRNPH1	physical	27129302
RS15A_HUMAN	RPS15A	physical	27129302
HNRLL_HUMAN	HNRNPLL	physical	27129302
HNRPD_HUMAN	HNRNPD	physical	27129302
ROA2_HUMAN	HNRNPA2B1	physical	27129302
FRG1_HUMAN	FRG1	physical	27129302
FEN1_HUMAN	FEN1	physical	27129302
FBRL_HUMAN	FBL	physical	27129302
DDX5_HUMAN	DDX5	physical	27129302
NOLC1_HUMAN	NOLC1	physical	27129302
YLPM1_HUMAN	YLPM1	physical	27129302
YBOX1_HUMAN	YBX1	physical	27129302
EZRI_HUMAN	EZR	physical	27129302
DDX46_HUMAN	DDX46	physical	27129302
IQEC1_HUMAN	IQSEC1	physical	27129302

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HEY1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25 AND SER-45, AND MASSSPECTROMETRY.	19413330 [Abstract]