CCD78_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD78_HUMAN
• UniProt AC: A2IDD5
• Protein Name: Coiled-coil domain-containing protein 78
• Gene Name: CCDC78
• Organism: Homo sapiens (Human).
• Sequence Length: 438
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, perinuclear region. Cell membrane, sarcolemma. Sarcoplasmic reticulum. Localizes to centrioles and deuterosome. Found primarily in the perinuclear region as wel
• Protein Description: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome..
• Protein Sequence: MEHAATTGPRPGPPSRRVENVVLRAKDWLPGAPGGTAVWATSLEAEVPPDLALNKEQQLQISKELVDIQITTHHLHEQHEAEIFQLKSEILRLESRVLELELRGDGTSQGCAVPVESDPRHPRAAAQELRHKAQVPGHSDDHRFQVQPKNTMNPENEQHRLGSGLQGEVKWALEHQEARQQALVTRVATLGRQLQGAREEARAAGQRLATQAVVLCSCQGQLRQAEAENARLQLQLKKLKDEYVLRLQHCAWQAVEHADGAGQAPATTALRTFLEATLEDIRAAHRSREQQLARAARSYHKRLVDLSRRHEELLVAYRAPGNPQAIFDIASLDLEPLPVPLVTDFSHREDQHGGPGALLSSPKKRPGGASQGGTSEPQGLDAASWAQIHQKLRDFSRSTQSWNGSGHSCWSGPRWLKSNFLSYRSTWTSTWAGTSTKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEHAATTGPRPGPP -CCCCCCCCCCCCCC	40.23	24719451
163	Phosphorylation	NEQHRLGSGLQGEVK CCCCCCCCCHHHHHH	40.70	27966365
317	Phosphorylation	HEELLVAYRAPGNPQ HHHHHHHHCCCCCCC	10.38	-
360	Phosphorylation	GGPGALLSSPKKRPG CCCCCCCCCCCCCCC	45.50	27251275
361	Phosphorylation	GPGALLSSPKKRPGG CCCCCCCCCCCCCCC	40.48	27966365

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD78_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD78_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD78_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CCD78_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.