dbPTM

IQEC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IQEC1_HUMAN
UniProt AC	Q6DN90
Protein Name	IQ motif and SEC7 domain-containing protein 1
Gene Name	IQSEC1
Organism	Homo sapiens (Human).
Sequence Length	963
Subcellular Localization	Cytoplasm . Nucleus . At steady state, may be preferentially cytosolic.
Protein Description	Guanine nucleotide exchange factor for ARF1 and ARF6. [PubMed: 24058294 Guanine nucleotide exchange factor activity is enhanced by lipid binding]
Protein Sequence	MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSVLCS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MWCLHCNSERTQSL -CEEEECCCHHHHHH	35.84	-
8	Phosphorylation	MWCLHCNSERTQSLL CEEEECCCHHHHHHH	33.57	28348404
32	Phosphorylation	GEAPSSETGTSLDSP CCCCCCCCCCCCCCC	47.94	24275569
38	Phosphorylation	ETGTSLDSPSAYPQG CCCCCCCCCCCCCCC	26.50	24275569
40	Phosphorylation	GTSLDSPSAYPQGPL CCCCCCCCCCCCCCC	44.37	24275569
42	Phosphorylation	SLDSPSAYPQGPLVP CCCCCCCCCCCCCCC	10.63	24275569
51	Phosphorylation	QGPLVPGSSLSPDHY CCCCCCCCCCCCCCC	23.26	24275569
52	Phosphorylation	GPLVPGSSLSPDHYE CCCCCCCCCCCCCCC	38.49	24275569
69	Phosphorylation	SVGAYGLYSGPPGQQ CCCCCCCCCCCCCCC	13.76	-
74	Phosphorylation	GLYSGPPGQQQRTRR CCCCCCCCCCCCCCC	40.85	24719451
75	Phosphorylation	LYSGPPGQQQRTRRP CCCCCCCCCCCCCCC	41.84	24719451
87	Phosphorylation	RRPKLQHSTSILRKQ CCCCCHHHHHHHHHH	15.76	29255136
88	Phosphorylation	RPKLQHSTSILRKQA CCCCHHHHHHHHHHH	20.05	29255136
89	Phosphorylation	PKLQHSTSILRKQAE CCCHHHHHHHHHHHH	23.73	29255136
91	Phosphorylation	LQHSTSILRKQAEEE CHHHHHHHHHHHHHH	5.84	27251275
93	Phosphorylation	HSTSILRKQAEEEAI HHHHHHHHHHHHHHH	50.87	24719451
95	Phosphorylation	TSILRKQAEEEAIKR HHHHHHHHHHHHHHH	29.24	27251275
103	Phosphorylation	EEEAIKRSRSLSESY HHHHHHHHHCHHHHH	22.63	25849741
105	Phosphorylation	EAIKRSRSLSESYEL HHHHHHHCHHHHHHC	37.18	22617229
107	Phosphorylation	IKRSRSLSESYELSS HHHHHCHHHHHHCCH	26.24	25159151
109	Phosphorylation	RSRSLSESYELSSDL HHHCHHHHHHCCHHH	22.11	22617229
110	Phosphorylation	SRSLSESYELSSDLQ HHCHHHHHHCCHHHH	19.48	28796482
113	Phosphorylation	LSESYELSSDLQDKQ HHHHHHCCHHHHHHH	15.18	28796482
114	Phosphorylation	SESYELSSDLQDKQV HHHHHCCHHHHHHHH	55.77	28796482
146	Phosphorylation	RTIQTAFRQYQMNKN HHHHHHHHHHHHHHH	31.65	27251275
152	Ubiquitination	FRQYQMNKNFERLRS HHHHHHHHHHHHHHH	58.64	-
159	Phosphorylation	KNFERLRSSMSENRM HHHHHHHHHHCCCHH	34.68	28348404
160	Phosphorylation	NFERLRSSMSENRMS HHHHHHHHHCCCHHH	21.64	25307156
162	Phosphorylation	ERLRSSMSENRMSRR HHHHHHHCCCHHHHH	33.40	29449344
166	Phosphorylation	SSMSENRMSRRIVLS HHHCCCHHHHHHHHH	5.72	27251275
167	Phosphorylation	SMSENRMSRRIVLSN HHCCCHHHHHHHHHC	18.37	-
180	Phosphorylation	SNMRMQFSFEGPEKV HCCEEEEEECCCCCC	12.90	18388127
184	Phosphorylation	MQFSFEGPEKVHSSY EEEEECCCCCCCCCC	30.91	24719451
190	Phosphorylation	GPEKVHSSYFEGKQV CCCCCCCCCCCCCEE	20.97	28555341
195	Ubiquitination	HSSYFEGKQVSVTND CCCCCCCCEEEECCC	40.09	-
197	Phosphorylation	SYFEGKQVSVTNDGS CCCCCCEEEECCCCC	5.91	27251275
198	Phosphorylation	YFEGKQVSVTNDGSQ CCCCCEEEECCCCCE	22.26	24719451
200	Phosphorylation	EGKQVSVTNDGSQLG CCCEEEECCCCCEEE	21.78	27251275
211	Phosphorylation	SQLGALVSPECGDLS CEEEEEECCCCCCCC	18.81	25159151
224	Ubiquitination	LSEPTTLKSPAPSSD CCCCCCCCCCCCCCH	52.91	-
225	Phosphorylation	SEPTTLKSPAPSSDF CCCCCCCCCCCCCHH	29.43	25849741
229	Phosphorylation	TLKSPAPSSDFADAI CCCCCCCCCHHHHHH	44.65	22199227
230	Phosphorylation	LKSPAPSSDFADAIT CCCCCCCCHHHHHHH	35.37	23090842
239	Phosphorylation	FADAITELEDAFSRQ HHHHHHHHHHHHHHH	5.59	24719451
248	Phosphorylation	DAFSRQVKSLAESID HHHHHHHHHHHHHHH	31.26	24719451
248	Ubiquitination	DAFSRQVKSLAESID HHHHHHHHHHHHHHH	31.26	-
249	Phosphorylation	AFSRQVKSLAESIDD HHHHHHHHHHHHHHH	33.67	29802988
253	Phosphorylation	QVKSLAESIDDALNC HHHHHHHHHHHHHHC	26.22	22617229
262	Phosphorylation	DDALNCRSLHTEEAP HHHHHCHHCCCCCCH	27.06	21712546
265	Phosphorylation	LNCRSLHTEEAPALD HHCHHCCCCCCHHHH	40.59	30108239
313	Phosphorylation	YIDEEELSPPLPLSQ EECHHHCCCCCCCHH	27.96	26074081
343	Phosphorylation	AGGAAPDYWALAHKE CCCCCCCCHHHHCCC	7.48	28796482
350	Phosphorylation	YWALAHKEDKADTDT CHHHHCCCCCCCCCC	55.68	24719451
355	Phosphorylation	HKEDKADTDTSCRST CCCCCCCCCCCCCCC	46.14	27732954
357	Phosphorylation	EDKADTDTSCRSTPS CCCCCCCCCCCCCCC	31.64	27732954
358	Phosphorylation	DKADTDTSCRSTPSL CCCCCCCCCCCCCCH	15.44	27732954
361	Phosphorylation	DTDTSCRSTPSLERQ CCCCCCCCCCCHHHH	49.34	24275569
362	Phosphorylation	TDTSCRSTPSLERQE CCCCCCCCCCHHHHH	9.50	27732954
364	Phosphorylation	TSCRSTPSLERQEQR CCCCCCCCHHHHHHH	42.84	28985074
372	Phosphorylation	LERQEQRLRVEHLPL HHHHHHHHHCCCCCE	7.80	24719451
379	Phosphorylation	LRVEHLPLLTIEPPS HHCCCCCEEEECCCC	9.19	27251275
382	Phosphorylation	EHLPLLTIEPPSDSS CCCCEEEECCCCCCC	8.25	24719451
386	Phosphorylation	LLTIEPPSDSSVDLS EEEECCCCCCCCCCC	61.92	27251275
388	Phosphorylation	TIEPPSDSSVDLSDR EECCCCCCCCCCCCC	36.28	28348404
389	Phosphorylation	IEPPSDSSVDLSDRS ECCCCCCCCCCCCCC	25.33	28348404
393	Phosphorylation	SDSSVDLSDRSERGS CCCCCCCCCCCCCCC	26.89	28348404
396	Phosphorylation	SVDLSDRSERGSLKR CCCCCCCCCCCCHHH	36.31	24719451
400	Phosphorylation	SDRSERGSLKRQSAY CCCCCCCCHHHHHHH	36.62	26699800
403	Phosphorylation	SERGSLKRQSAYERS CCCCCHHHHHHHHHH	40.76	24719451
405	Phosphorylation	RGSLKRQSAYERSLG CCCHHHHHHHHHHCC	36.53	21406692
407	Phosphorylation	SLKRQSAYERSLGGQ CHHHHHHHHHHCCCC	19.68	20068231
410	Phosphorylation	RQSAYERSLGGQQGS HHHHHHHHCCCCCCC	21.30	30266825
417	Phosphorylation	SLGGQQGSPKHGPHS HCCCCCCCCCCCCCC	26.83	25159151
424	Phosphorylation	SPKHGPHSGAPKSLP CCCCCCCCCCCCCCC	39.52	27174698
461	Phosphorylation	SANRQSKSESDYSDG CCCCCCCCCCCCCCC	47.80	28450419
462	Phosphorylation	ANRQSKSESDYSDGD CCCCCCCCCCCCCCC	51.90	27251275
463	Phosphorylation	NRQSKSESDYSDGDN CCCCCCCCCCCCCCC	49.27	28857561
465	Phosphorylation	QSKSESDYSDGDNDS CCCCCCCCCCCCCCC	20.24	28450419
466	Phosphorylation	SKSESDYSDGDNDSI CCCCCCCCCCCCCCC	39.86	28450419
472	Phosphorylation	YSDGDNDSINSTSNS CCCCCCCCCCCCCCC	29.89	28450419
475	Phosphorylation	GDNDSINSTSNSNDT CCCCCCCCCCCCCCC	31.38	28450419
476	Phosphorylation	DNDSINSTSNSNDTI CCCCCCCCCCCCCCC	27.69	28450419
477	Phosphorylation	NDSINSTSNSNDTIN CCCCCCCCCCCCCCC	37.77	28857561
479	Phosphorylation	SINSTSNSNDTINCS CCCCCCCCCCCCCCC	35.53	28857561
482	Phosphorylation	STSNSNDTINCSSES CCCCCCCCCCCCCCC	20.52	28857561
498	Phosphorylation	SRDSLREQTLSKQTY CHHHHHHHHHHHHHC	41.11	24719451
501	Phosphorylation	SLREQTLSKQTYHKE HHHHHHHHHHHCCHH	26.55	24719451
502	Ubiquitination	LREQTLSKQTYHKEA HHHHHHHHHHCCHHH	50.17	-
512	Phosphorylation	YHKEARNSWDSPAFS CCHHHHHCCCCCCCC	27.06	23927012
515	Phosphorylation	EARNSWDSPAFSNDV HHHHCCCCCCCCCHH	16.33	30266825
519	Phosphorylation	SWDSPAFSNDVIRKR CCCCCCCCCHHHHHH	33.94	30266825
684	Ubiquitination	MKLEDFIKNLRGVDD CCHHHHHHHHCCCCC	50.34	-
687	Methylation	EDFIKNLRGVDDGED HHHHHHHCCCCCCCC	53.10	115480443
797	Phosphorylation	IFQKKKNSVTYSFRQ HHHHCCCCCCEEEEH	25.39	30108239
852	Methylation	PNPQDRKKFTDDLRE CCHHHHHHCCHHHHH	55.16	115971529
874	Phosphorylation	MEKHRIESELEKQKG HHHHHHHHHHHHCCC	45.14	24719451
878	Phosphorylation	RIESELEKQKGVVRP HHHHHHHHCCCCCCC	70.68	24719451
886	Phosphorylation	QKGVVRPSMSQCSSL CCCCCCCCHHHHHHC	22.09	29978859
888	Phosphorylation	GVVRPSMSQCSSLKK CCCCCCHHHHHHCCC	32.16	29978859
891	Phosphorylation	RPSMSQCSSLKKESG CCCHHHHHHCCCCCC	30.94	29978859
892	Phosphorylation	PSMSQCSSLKKESGN CCHHHHHHCCCCCCC	52.41	25159151
896	Phosphorylation	QCSSLKKESGNGTLS HHHHCCCCCCCCCCC	63.39	27251275
897	Phosphorylation	CSSLKKESGNGTLSR HHHCCCCCCCCCCCH	46.57	21712546
901	Phosphorylation	KKESGNGTLSRACLD CCCCCCCCCCHHHHC	26.09	21712546
910	Phosphorylation	SRACLDDSYASGEGL CHHHHCCCCCCCHHH	23.43	28796482
911	Phosphorylation	RACLDDSYASGEGLK HHHHCCCCCCCHHHH	16.28	28796482
913	Phosphorylation	CLDDSYASGEGLKRS HHCCCCCCCHHHHHH	29.19	29978859
918	Methylation	YASGEGLKRSALSSS CCCCHHHHHHHHHHH	55.98	115971537
920	Phosphorylation	SGEGLKRSALSSSLR CCHHHHHHHHHHHHH	31.79	23403867
923	Phosphorylation	GLKRSALSSSLRDLS HHHHHHHHHHHHHHH	20.00	29255136
924	Phosphorylation	LKRSALSSSLRDLSE HHHHHHHHHHHHHHH	33.95	30266825
925	Phosphorylation	KRSALSSSLRDLSEA HHHHHHHHHHHHHHH	24.85	23927012
925	Phosphorylation	KRSALSSSLRDLSEA HHHHHHHHHHHHHHH	24.85	23401153
926	Phosphorylation	RSALSSSLRDLSEAG HHHHHHHHHHHHHHH	5.51	23927012
926	Phosphorylation	RSALSSSLRDLSEAG HHHHHHHHHHHHHHH	5.51	27251275
929	Phosphorylation	LSSSLRDLSEAGKRG HHHHHHHHHHHHHHC	3.94	23927012
929	Phosphorylation	LSSSLRDLSEAGKRG HHHHHHHHHHHHHHC	3.94	24719451
930	Phosphorylation	SSSLRDLSEAGKRGR HHHHHHHHHHHHHCC	29.68	23403867
932	Phosphorylation	SLRDLSEAGKRGRRS HHHHHHHHHHHCCCC	25.98	23927012
932	Phosphorylation	SLRDLSEAGKRGRRS HHHHHHHHHHHCCCC	25.98	24719451
937	Phosphorylation	SEAGKRGRRSSAGSL HHHHHHCCCCCCCCC	39.06	25219547
939	Phosphorylation	AGKRGRRSSAGSLES HHHHCCCCCCCCCCC	24.15	25849741
940	Phosphorylation	GKRGRRSSAGSLESN HHHCCCCCCCCCCCC	34.53	23927012
940	Phosphorylation	GKRGRRSSAGSLESN HHHCCCCCCCCCCCC	34.53	22496350
941	Phosphorylation	KRGRRSSAGSLESNV HHCCCCCCCCCCCCC	16.91	23927012
943	Phosphorylation	GRRSSAGSLESNVEF CCCCCCCCCCCCCCC	28.78	-
971	Phosphorylation	--------------- ---------------		27251275
975	Phosphorylation	------------------- -------------------		27251275
975	Phosphorylation	------------------- -------------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IQEC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IQEC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IQEC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAQ_HUMAN	GNAQ	physical	17846866
CTNA1_HUMAN	CTNNA1	physical	16807291
ARF6_HUMAN	ARF6	physical	11226253

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IQEC1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-512, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-512, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-512, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-362, AND MASSSPECTROMETRY.	15302935 [Abstract]