UniProt ID | ST38L_HUMAN | |
---|---|---|
UniProt AC | Q9Y2H1 | |
Protein Name | Serine/threonine-protein kinase 38-like | |
Gene Name | STK38L {ECO:0000312|EMBL:AAH28603.1} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 464 | |
Subcellular Localization | Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane. | |
Protein Description | Involved in the regulation of structural processes in differentiating and mature neuronal cells.. | |
Protein Sequence | MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MAMTAGTTT ------CCCCCCCEE | 12.20 | - | |
4 | Phosphorylation | ----MAMTAGTTTTF ----CCCCCCCEEEE | 16.64 | 23401153 | |
7 | Phosphorylation | -MAMTAGTTTTFPMS -CCCCCCCEEEECCC | 20.64 | 21406692 | |
8 | Phosphorylation | MAMTAGTTTTFPMSN CCCCCCCEEEECCCC | 23.95 | 23401153 | |
9 | Phosphorylation | AMTAGTTTTFPMSNH CCCCCCEEEECCCCC | 26.69 | 23401153 | |
10 | Phosphorylation | MTAGTTTTFPMSNHT CCCCCEEEECCCCCC | 24.53 | 23401153 | |
14 | Phosphorylation | TTTTFPMSNHTRERV CEEEECCCCCCHHCE | 26.20 | 23401153 | |
17 | Phosphorylation | TFPMSNHTRERVTVA EECCCCCCHHCEEEE | 38.18 | 23401153 | |
17 | Ubiquitination | TFPMSNHTRERVTVA EECCCCCCHHCEEEE | 38.18 | - | |
21 | Ubiquitination | SNHTRERVTVAKLTL CCCCHHCEEEEEEHH | 4.29 | 24816145 | |
26 | Ubiquitination | ERVTVAKLTLENFYS HCEEEEEEHHHHHHH | 4.82 | - | |
30 | Ubiquitination | VAKLTLENFYSNLIL EEEEHHHHHHHHHHH | 44.24 | 24816145 | |
32 | Phosphorylation | KLTLENFYSNLILQH EEHHHHHHHHHHHHH | 14.29 | 27642862 | |
42 | Ubiquitination | LILQHEERETRQKKL HHHHHHHHHHHHHHH | 47.83 | 22817900 | |
71 | Ubiquitination | KLRRSQHARKETEFL HHHHHHHHHHHHHHH | 19.32 | 24816145 | |
73 | Ubiquitination | RRSQHARKETEFLRL HHHHHHHHHHHHHHH | 70.53 | 24816145 | |
75 | Phosphorylation | SQHARKETEFLRLKR HHHHHHHHHHHHHHC | 34.76 | 28857561 | |
82 | Ubiquitination | TEFLRLKRTRLGLDD HHHHHHHCCCCCCCC | 29.66 | 24816145 | |
94 | Ubiquitination | LDDFESLKVIGRGAF CCCHHHCEEEECCCC | 40.88 | 21906983 | |
110 | Ubiquitination | EVRLVQKKDTGHIYA EEEEEEECCCCCEEE | 43.35 | - | |
116 | Phosphorylation | KKDTGHIYAMKILRK ECCCCCEEEEEEHHH | 8.58 | 29496907 | |
119 | Ubiquitination | TGHIYAMKILRKSDM CCCEEEEEEHHHHHC | 30.34 | - | |
122 | Ubiquitination | IYAMKILRKSDMLEK EEEEEEHHHHHCCCH | 39.65 | - | |
122 | Ubiquitination | IYAMKILRKSDMLEK EEEEEEHHHHHCCCH | 39.65 | 22817900 | |
123 | Ubiquitination | YAMKILRKSDMLEKE EEEEEHHHHHCCCHH | 47.57 | 24816145 | |
129 | Ubiquitination | RKSDMLEKEQVAHIR HHHHCCCHHHHHHHH | 49.86 | 29967540 | |
131 | Ubiquitination | SDMLEKEQVAHIRAE HHCCCHHHHHHHHHH | 49.09 | 22817900 | |
131 | Ubiquitination | SDMLEKEQVAHIRAE HHCCCHHHHHHHHHH | 49.09 | - | |
135 | Ubiquitination | EKEQVAHIRAERDIL CHHHHHHHHHHCCEE | 3.00 | 22817900 | |
135 | Ubiquitination | EKEQVAHIRAERDIL CHHHHHHHHHHCCEE | 3.00 | - | |
146 | Ubiquitination | RDILVEADGAWVVKM CCEEEEECCCEEEEE | 33.56 | - | |
147 | Ubiquitination | DILVEADGAWVVKMF CEEEEECCCEEEEEE | 28.52 | - | |
163 | Ubiquitination | SFQDKRNLYLIMEFL EECCCCCEEEEEECC | 4.23 | 22817900 | |
164 | Phosphorylation | FQDKRNLYLIMEFLP ECCCCCEEEEEECCC | 9.57 | 23532336 | |
172 | Ubiquitination | LIMEFLPGGDMMTLL EEEECCCCCCHHHEE | 47.05 | 22817900 | |
173 | Ubiquitination | IMEFLPGGDMMTLLM EEECCCCCCHHHEEE | 20.08 | - | |
173 | Ubiquitination | IMEFLPGGDMMTLLM EEECCCCCCHHHEEE | 20.08 | 27667366 | |
174 | Ubiquitination | MEFLPGGDMMTLLMK EECCCCCCHHHEEEC | 29.60 | 22817900 | |
176 | Ubiquitination | FLPGGDMMTLLMKKD CCCCCCHHHEEECCC | 2.58 | 22817900 | |
177 | Phosphorylation | LPGGDMMTLLMKKDT CCCCCHHHEEECCCC | 15.31 | 23532336 | |
183 | Ubiquitination | MTLLMKKDTLTEEET HHEEECCCCCCHHHH | 41.24 | 22817900 | |
184 | Phosphorylation | TLLMKKDTLTEEETQ HEEECCCCCCHHHHH | 44.45 | - | |
187 | Ubiquitination | MKKDTLTEEETQFYI ECCCCCCHHHHHHHH | 57.88 | 22817900 | |
214 | Ubiquitination | LGFIHRDIKPDNLLL HCCCCCCCCCCCEEE | 7.61 | 27667366 | |
215 | Ubiquitination | GFIHRDIKPDNLLLD CCCCCCCCCCCEEEC | 51.08 | 21906983 | |
224 | Ubiquitination | DNLLLDAKGHVKLSD CCEEECCCCCEEHHH | 49.57 | 21906983 | |
225 | Ubiquitination | NLLLDAKGHVKLSDF CEEECCCCCEEHHHC | 32.32 | 27667366 | |
228 | Ubiquitination | LDAKGHVKLSDFGLC ECCCCCEEHHHCCCC | 36.28 | 22817900 | |
236 | Phosphorylation | LSDFGLCTGLKKAHR HHHCCCCCCCCHHHH | 51.06 | 20068231 | |
239 | Ubiquitination | FGLCTGLKKAHRTEF CCCCCCCCHHHHCHH | 49.62 | - | |
259 | Phosphorylation | HNPPSDFSFQNMNSK CCCCCCCCCCCCCCH | 30.80 | 28122231 | |
265 | Phosphorylation | FSFQNMNSKRKAETW CCCCCCCCHHHHHHH | 24.06 | 28450419 | |
266 | Ubiquitination | SFQNMNSKRKAETWK CCCCCCCHHHHHHHH | 53.57 | 27667366 | |
281 | Phosphorylation | KNRRQLAYSTVGTPD HHHHHHHHCCCCCCC | 17.29 | 21712546 | |
282 | Phosphorylation | NRRQLAYSTVGTPDY HHHHHHHCCCCCCCC | 15.83 | 23401153 | |
283 | Phosphorylation | RRQLAYSTVGTPDYI HHHHHHCCCCCCCCC | 15.41 | 21712546 | |
285 | Ubiquitination | QLAYSTVGTPDYIAP HHHHCCCCCCCCCCH | 31.45 | - | |
286 | Phosphorylation | LAYSTVGTPDYIAPE HHHCCCCCCCCCCHH | 14.51 | 28102081 | |
289 | Phosphorylation | STVGTPDYIAPEVFM CCCCCCCCCCHHHHH | 10.53 | 23403867 | |
298 | Phosphorylation | APEVFMQTGYNKLCD CHHHHHHCCCHHHHH | 29.82 | 21406692 | |
300 | Phosphorylation | EVFMQTGYNKLCDWW HHHHHCCCHHHHHHH | 16.71 | 21406692 | |
355 | Ubiquitination | VPISEKAKDLILRFC CCCCHHHHHHHHHHH | 65.22 | - | |
367 | Ubiquitination | RFCIDSENRIGNSGV HHHCCCCCCCCCCCC | 44.83 | - | |
378 | Ubiquitination | NSGVEEIKGHPFFEG CCCCHHHCCCCCCCC | 55.22 | 29967540 | |
403 | Ubiquitination | AAIPIEIKSIDDTSN CCCCEEEEECCCCCC | 28.68 | 29967540 | |
441 | Phosphorylation | KDWVFLNYTYKRFEG CCEEEEEEEEEECCC | 17.37 | 29523821 | |
442 | Phosphorylation | DWVFLNYTYKRFEGL CEEEEEEEEEECCCC | 22.84 | 22322096 | |
443 | Phosphorylation | WVFLNYTYKRFEGLT EEEEEEEEEECCCCC | 6.98 | 22322096 | |
450 | Phosphorylation | YKRFEGLTQRGSIPT EEECCCCCCCCCCCC | 27.38 | 23403867 | |
452 | Methylation | RFEGLTQRGSIPTYM ECCCCCCCCCCCCCC | 35.27 | 115484663 | |
454 | Phosphorylation | EGLTQRGSIPTYMKA CCCCCCCCCCCCCCC | 27.81 | 23403867 | |
457 | Phosphorylation | TQRGSIPTYMKAGKL CCCCCCCCCCCCCCC | 34.28 | 23403867 | |
458 | Phosphorylation | QRGSIPTYMKAGKL- CCCCCCCCCCCCCC- | 7.40 | 20068231 | |
460 | Ubiquitination | GSIPTYMKAGKL--- CCCCCCCCCCCC--- | 43.50 | - |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ST38L_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ST38L_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
K1H1_HUMAN | KRT31 | physical | 17353931 | |
MOB1A_HUMAN | MOB1A | physical | 17353931 | |
MOB2_HUMAN | MOB2 | physical | 20624913 | |
MOB2_HUMAN | MOB2 | physical | 15067004 | |
MOB1B_HUMAN | MOB1B | physical | 15067004 | |
MOB2_HUMAN | MOB2 | physical | 25852190 | |
MOB1A_HUMAN | MOB1A | physical | 25852190 | |
CDC37_HUMAN | CDC37 | physical | 24366813 | |
MOB1A_HUMAN | MOB1A | physical | 24366813 | |
MOB1B_HUMAN | MOB1B | physical | 24366813 | |
MOB2_HUMAN | MOB2 | physical | 24366813 | |
TRY1_HUMAN | PRSS1 | physical | 24366813 | |
MOB2_HUMAN | MOB2 | physical | 28514442 | |
MOB1A_HUMAN | MOB1A | physical | 28514442 | |
PERI_HUMAN | PRPH | physical | 28514442 | |
HEY1_HUMAN | HEY1 | physical | 27129302 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Regulation of NDR2 protein kinase by multi-site phosphorylation andthe S100B calcium-binding protein."; Stegert M.R., Tamaskovic R., Bichsel S.J., Hergovich A.,Hemmings B.A.; J. Biol. Chem. 279:23806-23812(2004). Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, ENZYMEREGULATION, INTERACTION WITH S100, PHOSPHORYLATION AT THR-75; SER-282AND THR-442, AND MUTAGENESIS OF THR-75; LYS-119; SER-282 AND THR-442. | |
"Regulation of NDR protein kinase by hydrophobic motif phosphorylationmediated by the mammalian Ste20-like kinase MST3."; Stegert M.R., Hergovich A., Tamaskovic R., Bichsel S.J.,Hemmings B.A.; Mol. Cell. Biol. 25:11019-11029(2005). Cited for: PHOSPHORYLATION AT THR-442, ENZYME REGULATION, AND SUBCELLULARLOCATION. |