dbPTM

SNR27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SNR27_HUMAN
UniProt AC	Q8WVK2
Protein Name	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
Gene Name	SNRNP27
Organism	Homo sapiens (Human).
Sequence Length	155
Subcellular Localization	Nucleus .
Protein Description	May play a role in mRNA splicing..
Protein Sequence	MGRSRSRSPRRERRRSRSTSRERERRRRERSRSRERDRRRSRSRSPHRRRSRSPRRHRSTSPSPSRLKERRDEEKKETKETKSKERQITEEDLEGKTEEEIEMMKLMGFASFDSTKGKKVDGSVNAYAINVSQKRKYRQYMNRKGGFNRPLDFIA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGRSRSRSPRR ----CCCCCCCCHHH	28.95	22468782
6	Phosphorylation	--MGRSRSRSPRRER --CCCCCCCCHHHHH	38.05	20068231
8	Phosphorylation	MGRSRSRSPRRERRR CCCCCCCCHHHHHHH	24.81	20068231
31	Phosphorylation	ERRRRERSRSRERDR HHHHHHHHHHHHHHH	29.83	30576142
33	Phosphorylation	RRRERSRSRERDRRR HHHHHHHHHHHHHHH	39.48	30576142
41	Phosphorylation	RERDRRRSRSRSPHR HHHHHHHHHCCCHHH	32.56	30576142
43	Phosphorylation	RDRRRSRSRSPHRRR HHHHHHHCCCHHHHH	38.05	30576142
45	Phosphorylation	RRRSRSRSPHRRRSR HHHHHCCCHHHHHCC	26.72	30576142
51	Phosphorylation	RSPHRRRSRSPRRHR CCHHHHHCCCCCCCC	34.99	30576142
53	Phosphorylation	PHRRRSRSPRRHRST HHHHHCCCCCCCCCC	24.81	30576142
59	Phosphorylation	RSPRRHRSTSPSPSR CCCCCCCCCCCCHHH	27.41	27273156
60	Phosphorylation	SPRRHRSTSPSPSRL CCCCCCCCCCCHHHH	44.61	27273156
61	Phosphorylation	PRRHRSTSPSPSRLK CCCCCCCCCCHHHHH	25.32	21955146
63	Phosphorylation	RHRSTSPSPSRLKER CCCCCCCCHHHHHHH	34.96	27273156
65	Phosphorylation	RSTSPSPSRLKERRD CCCCCCHHHHHHHHH	55.36	22617229
81	Phosphorylation	EKKETKETKSKERQI HHHHHHHHHHHHHCC	42.02	26074081
83	Phosphorylation	KETKETKSKERQITE HHHHHHHHHHHCCCH	47.36	26074081
97	Phosphorylation	EEDLEGKTEEEIEMM HHHHCCCCHHHHHHH	60.53	26503514
107	Sulfoxidation	EIEMMKLMGFASFDS HHHHHHHHCCCCCCC	3.28	21406390
111	Phosphorylation	MKLMGFASFDSTKGK HHHHCCCCCCCCCCC	27.59	26074081
114	Phosphorylation	MGFASFDSTKGKKVD HCCCCCCCCCCCCCC	29.97	26074081
115	Phosphorylation	GFASFDSTKGKKVDG CCCCCCCCCCCCCCC	45.73	26074081
123	Phosphorylation	KGKKVDGSVNAYAIN CCCCCCCCEEEEEEE	14.03	26074081
127	Phosphorylation	VDGSVNAYAINVSQK CCCCEEEEEEEHHHH	11.65	25159151
132	Phosphorylation	NAYAINVSQKRKYRQ EEEEEEHHHHHHHHH	26.04	23401153
134	Ubiquitination	YAINVSQKRKYRQYM EEEEHHHHHHHHHHH	43.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SNR27_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SNR27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SNR27_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHERP_HUMAN	CHERP	physical	22365833
SRPK2_HUMAN	SRPK2	physical	22365833
ARGL1_HUMAN	ARGLU1	physical	26344197
RECQ1_HUMAN	RECQL	physical	28514442
WDR5B_HUMAN	WDR5B	physical	28514442
CAR19_HUMAN	C9orf89	physical	28514442
EIF2A_HUMAN	EIF2A	physical	28514442
SBDS_HUMAN	SBDS	physical	28514442
SNX3_HUMAN	SNX3	physical	28514442
RBM12_HUMAN	RBM12	physical	28514442
PAK3_HUMAN	PAK3	physical	28514442
SNR40_HUMAN	SNRNP40	physical	28514442
LC7L2_HUMAN	LUC7L2	physical	28514442
NAA15_HUMAN	NAA15	physical	28514442
LETM1_HUMAN	LETM1	physical	28514442
PAK2_HUMAN	PAK2	physical	28514442
SLK_HUMAN	SLK	physical	28514442
TOPK_HUMAN	PBK	physical	28514442
OXSR1_HUMAN	OXSR1	physical	28514442
DENR_HUMAN	DENR	physical	28514442
FEN1_HUMAN	FEN1	physical	28514442
SYNC_HUMAN	NARS	physical	28514442
TPP2_HUMAN	TPP2	physical	28514442
DDX46_HUMAN	DDX46	physical	28514442
CTBL1_HUMAN	CTNNBL1	physical	28514442
VRK1_HUMAN	VRK1	physical	28514442
BLVRB_HUMAN	BLVRB	physical	28514442
PMVK_HUMAN	PMVK	physical	28514442
ARMT1_HUMAN	C6orf211	physical	28514442
SNX6_HUMAN	SNX6	physical	28514442
VIGLN_HUMAN	HDLBP	physical	28514442
NB5R3_HUMAN	CYB5R3	physical	28514442
CGBP1_HUMAN	CGGBP1	physical	28514442
PUR8_HUMAN	ADSL	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
LASP1_HUMAN	LASP1	physical	28514442
ERF1_HUMAN	ETF1	physical	28514442
PDC10_HUMAN	PDCD10	physical	28514442
GLSK_HUMAN	GLS	physical	28514442
CCD51_HUMAN	CCDC51	physical	28514442
PIN1_HUMAN	PIN1	physical	28514442
UBE2T_HUMAN	UBE2T	physical	28514442
PARP1_HUMAN	PARP1	physical	28514442
S10AD_HUMAN	S100A13	physical	28514442
RPR1A_HUMAN	RPRD1A	physical	28514442
HINT1_HUMAN	HINT1	physical	28514442
PP1R8_HUMAN	PPP1R8	physical	28514442
RRP44_HUMAN	DIS3	physical	28514442
RPR1B_HUMAN	RPRD1B	physical	28514442
PPIL4_HUMAN	PPIL4	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
ARF6_HUMAN	ARF6	physical	28514442
PTN11_HUMAN	PTPN11	physical	28514442
MK03_HUMAN	MAPK3	physical	28514442
PSMF1_HUMAN	PSMF1	physical	28514442
PAPS1_HUMAN	PAPSS1	physical	28514442
MTX3_HUMAN	MTX3	physical	28514442
USO1_HUMAN	USO1	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
PRRC1_HUMAN	PRRC1	physical	28514442
DUS3_HUMAN	DUSP3	physical	28514442
UBA6_HUMAN	UBA6	physical	28514442
EEA1_HUMAN	EEA1	physical	28514442
HDGR2_HUMAN	HDGFRP2	physical	28514442
MCTS1_HUMAN	MCTS1	physical	28514442
CKAP5_HUMAN	CKAP5	physical	28514442
P4R3A_HUMAN	SMEK1	physical	28514442
TKFC_HUMAN	DAK	physical	28514442
S23IP_HUMAN	SEC23IP	physical	28514442
QRIC1_HUMAN	QRICH1	physical	28514442
NAA50_HUMAN	NAA50	physical	28514442
ARF5_HUMAN	ARF5	physical	28514442
TXLNG_HUMAN	TXLNG	physical	28514442
OTUB1_HUMAN	OTUB1	physical	28514442
TLN1_HUMAN	TLN1	physical	28514442
HSP7E_HUMAN	HSPA14	physical	28514442
MARE2_HUMAN	MAPRE2	physical	28514442
NHRF1_HUMAN	SLC9A3R1	physical	28514442
TXLNA_HUMAN	TXLNA	physical	28514442
CND1_HUMAN	NCAPD2	physical	28514442
SAR1B_HUMAN	SAR1B	physical	28514442
SYAP1_HUMAN	SYAP1	physical	28514442
TOM34_HUMAN	TOMM34	physical	28514442
SF3A1_HUMAN	SF3A1	physical	28514442
CHRD1_HUMAN	CHORDC1	physical	28514442
T2FA_HUMAN	GTF2F1	physical	28514442
KAD4_HUMAN	AK4	physical	28514442
CHD4_HUMAN	CHD4	physical	28514442
HMGN5_HUMAN	HMGN5	physical	28514442
RAB2A_HUMAN	RAB2A	physical	28514442
QKI_HUMAN	QKI	physical	28514442
NUP53_HUMAN	NUP35	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
PICAL_HUMAN	PICALM	physical	28514442
KPYM_HUMAN	PKM	physical	28514442
STK26_HUMAN	STK26	physical	28514442
ILKAP_HUMAN	ILKAP	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SNR27_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59; THR-60; SER-61 ANDSER-65, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51 AND SER-53, AND MASSSPECTROMETRY.	17081983 [Abstract]