dbPTM

SAR1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SAR1B_HUMAN
UniProt AC	Q9Y6B6
Protein Name	GTP-binding protein SAR1b
Gene Name	SAR1B
Organism	Homo sapiens (Human).
Sequence Length	198
Subcellular Localization	Endoplasmic reticulum membrane Peripheral membrane protein. Golgi apparatus, Golgi stack membrane Peripheral membrane protein. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region..
Protein Description	Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex..
Protein Sequence	MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMTDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSVLKRQGYGEGFRWMAQYID

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFIFDWIY ------CCCHHHHHH	27.35	20068231
9	Phosphorylation	SFIFDWIYSGFSSVL CCHHHHHHHCHHHHH	9.85	20068231
10	Phosphorylation	FIFDWIYSGFSSVLQ CHHHHHHHCHHHHHH	24.99	20068231
13	Phosphorylation	DWIYSGFSSVLQFLG HHHHHCHHHHHHHHH	24.06	20068231
14	Phosphorylation	WIYSGFSSVLQFLGL HHHHCHHHHHHHHHH	25.28	22617229
22	Phosphorylation	VLQFLGLYKKTGKLV HHHHHHHHHHCCCEE	14.51	20068231
39	Phosphorylation	GLDNAGKTTLLHMLK ECCCCCCEEHHHHHC	23.04	21406692
40	Phosphorylation	LDNAGKTTLLHMLKD CCCCCCEEHHHHHCC	30.70	21406692
46	Ubiquitination	TTLLHMLKDDRLGQH EEHHHHHCCCCCCCC	50.43	23000965
60	Phosphorylation	HVPTLHPTSEELTIA CCCCCCCCCCCEEEC	37.71	-
89	Phosphorylation	ARRVWKNYLPAINGI HHHHHHHHHHHHCEE	15.44	-
117	Phosphorylation	ESKEELDSLMTDETI HCHHHHHHHCCCCHH	32.44	26074081
120	Phosphorylation	EELDSLMTDETIANV HHHHHHCCCCHHHCC	35.66	26074081
123	Phosphorylation	DSLMTDETIANVPIL HHHCCCCHHHCCCEE	28.35	26074081
143	Phosphorylation	IDRPEAISEERLREM CCCCHHCCHHHHHHH	40.22	26074081
157	Phosphorylation	MFGLYGQTTGKGSIS HHCCCCCCCCCCCEE	32.90	20068231
158	Phosphorylation	FGLYGQTTGKGSISL HCCCCCCCCCCCEEH	29.07	20068231
162	Phosphorylation	GQTTGKGSISLKELN CCCCCCCCEEHHHHC	16.70	28060719
164	Phosphorylation	TTGKGSISLKELNAR CCCCCCEEHHHHCCC	34.78	28060719
166	Ubiquitination	GKGSISLKELNARPL CCCCEEHHHHCCCCE	54.05	33845483
182	Ubiquitination	VFMCSVLKRQGYGEG EHHHHHHHHCCCCCC	40.29	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SAR1B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SAR1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SAR1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
HNRH1_HUMAN	HNRNPH1	physical	26344197

Drug and Disease Associations

Kegg Disease
H00927	Chylomicron retention disease (CRD); Anderson disease
OMIM Disease
246700	Chylomicron retention disease (CMRD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SAR1B_HUMAN

Related Literatures of Post-Translational Modification