| UniProt ID | TKFC_HUMAN | |
|---|---|---|
| UniProt AC | Q3LXA3 | |
| Protein Name | Triokinase/FMN cyclase {ECO:0000312|HGNC:HGNC:24552} | |
| Gene Name | TKFC {ECO:0000312|HGNC:HGNC:24552} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 575 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response. [PubMed: 17600090] | |
| Protein Sequence | MTSKKLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDSLKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTSPAVGSILAAIRAVAQAGTVGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFTVLKKAGRRGLCGTVLIHKVAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGSKPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKLMLDHMTNTTNASHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLTLLLVDEPLLKLIDAETTAAAWPNVAAVSITGRKRSRVAPAEPQEAPDSTAAGGSASKRMALVLERVCSTLLGLEEHLNALDRAAGDGDCGTTHSRAARAIQEWLKEGPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLTAAAQPLKAKTSLPAWSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKSAEAAAEATKNMEAGAGRASYISSARLEQPDPGAVAAAAILRAILEVLQS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | ALRSDLDSLKGRVAL HHHHCHHHCCCCEEE | 28857561 | ||
| 46 | Ubiquitination | RSDLDSLKGRVALLS HHCHHHCCCCEEEEC | - | ||
| 53 | Phosphorylation | KGRVALLSGGGSGHE CCCEEEECCCCCCCC | 23312004 | ||
| 57 | Phosphorylation | ALLSGGGSGHEPAHA EEECCCCCCCCCCCC | 28857561 | ||
| 112 | Phosphorylation | LLIVKNYTGDRLNFG EEEEECCCCCCCCHH | 28857561 | ||
| 115 | Methylation | VKNYTGDRLNFGLAR EECCCCCCCCHHHHH | - | ||
| 147 | 2-Hydroxyisobutyrylation | DSAFTVLKKAGRRGL CHHHHHHHHHCCCCC | - | ||
| 157 | Phosphorylation | GRRGLCGTVLIHKVA CCCCCCCHHHHHHHH | 28857561 | ||
| 343 | Phosphorylation | WPNVAAVSITGRKRS CCCEEEEEECCCCCC | 28857561 | ||
| 345 | Phosphorylation | NVAAVSITGRKRSRV CEEEEEECCCCCCCC | 24275569 | ||
| 350 | Phosphorylation | SITGRKRSRVAPAEP EECCCCCCCCCCCCC | 20166139 | ||
| 363 | Phosphorylation | EPQEAPDSTAAGGSA CCCCCCCCCCCCCCH | 23927012 | ||
| 364 | Phosphorylation | PQEAPDSTAAGGSAS CCCCCCCCCCCCCHH | 24275569 | ||
| 369 | Phosphorylation | DSTAAGGSASKRMAL CCCCCCCCHHHHHHH | 28192239 | ||
| 371 | Phosphorylation | TAAGGSASKRMALVL CCCCCCHHHHHHHHH | 28857561 | ||
| 372 | Ubiquitination | AAGGSASKRMALVLE CCCCCHHHHHHHHHH | 21890473 | ||
| 372 | Acetylation | AAGGSASKRMALVLE CCCCCHHHHHHHHHH | 25953088 | ||
| 404 | S-nitrosocysteine | RAAGDGDCGTTHSRA HHCCCCCCCHHHHHH | - | ||
| 420 | Ubiquitination | RAIQEWLKEGPPPAS HHHHHHHHHCCCCCC | - | ||
| 427 | Phosphorylation | KEGPPPASPAQLLSK HHCCCCCCHHHHHHH | 30624053 | ||
| 433 | Phosphorylation | ASPAQLLSKLSVLLL CCHHHHHHHHHHHHH | 24719451 | ||
| 436 | Phosphorylation | AQLLSKLSVLLLEKM HHHHHHHHHHHHHHH | 20068231 | ||
| 446 | Phosphorylation | LLEKMGGSSGALYGL HHHHHCCCCHHHHHH | 21902226 | ||
| 447 | Phosphorylation | LEKMGGSSGALYGLF HHHHCCCCHHHHHHH | 21902226 | ||
| 456 | Phosphorylation | ALYGLFLTAAAQPLK HHHHHHHHHHCCCCC | 21902226 | ||
| 465 | Ubiquitination | AAQPLKAKTSLPAWS HCCCCCCCCCCHHHH | - | ||
| 466 | Phosphorylation | AQPLKAKTSLPAWSA CCCCCCCCCCHHHHH | 28857561 | ||
| 467 | Phosphorylation | QPLKAKTSLPAWSAA CCCCCCCCCHHHHHH | 28857561 | ||
| 484 | Ubiquitination | AGLEAMQKYGKAAPG HHHHHHHHHCCCCCC | - | ||
| 511 | Phosphorylation | QELQAWKSPGADLLQ HHHHHHCCCCHHHHH | 28258704 | ||
| 521 | Phosphorylation | ADLLQVLTKAVKSAE HHHHHHHHHHHHHHH | 28857561 | ||
| 522 | Ubiquitination | DLLQVLTKAVKSAEA HHHHHHHHHHHHHHH | 21906983 | ||
| 522 | Ubiquitination | DLLQVLTKAVKSAEA HHHHHHHHHHHHHHH | 21890473 | ||
| 525 | Ubiquitination | QVLTKAVKSAEAAAE HHHHHHHHHHHHHHH | - | ||
| 545 | Phosphorylation | EAGAGRASYISSARL CCCCCCHHEECCCCC | 24972180 | ||
| 546 | Phosphorylation | AGAGRASYISSARLE CCCCCHHEECCCCCC | 27642862 | ||
| 548 | Phosphorylation | AGRASYISSARLEQP CCCHHEECCCCCCCC | 28857561 | ||
| 549 | Phosphorylation | GRASYISSARLEQPD CCHHEECCCCCCCCC | 28857561 | ||
| 575 | Phosphorylation | AILEVLQS------- HHHHHHHC------- | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TKFC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TKFC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TKFC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FAD1_HUMAN | FLAD1 | physical | 22939629 | |
| ENOB_HUMAN | ENO3 | physical | 22939629 | |
| THIC_HUMAN | ACAT2 | physical | 22939629 | |
| GLGB_HUMAN | GBE1 | physical | 22939629 | |
| GDE_HUMAN | AGL | physical | 22939629 | |
| FERM2_HUMAN | FERMT2 | physical | 22863883 | |
| GBP1_HUMAN | GBP1 | physical | 22863883 | |
| SIAS_HUMAN | NANS | physical | 22863883 | |
| PSA_HUMAN | NPEPPS | physical | 22863883 | |
| PDIA3_HUMAN | PDIA3 | physical | 22863883 | |
| NHRF1_HUMAN | SLC9A3R1 | physical | 22863883 | |
| SPSY_HUMAN | SMS | physical | 22863883 | |
| 1433B_HUMAN | YWHAB | physical | 22863883 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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