ENOB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENOB_HUMAN
• UniProt AC: P13929
• Protein Name: Beta-enolase
• Gene Name: ENO3
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Cytoplasm. Localized to the Z line. Some colocalization with CKM at M-band (By similarity)..
• Protein Description: Appears to have a function in striated muscle development and regeneration..
• Protein Sequence: MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLGKGVLKAVENINNTLGPALLQKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAIFAGRKFRNPKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMQKIFAR ------CCHHHHHHH	14.76	22814378
19	Phosphorylation	LDSRGNPTVEVDLHT HHCCCCCEEEEEEEC	33.04	26437602
26	Phosphorylation	TVEVDLHTAKGRFRA EEEEEEECCCCCEEE	37.04	-
28	Ubiquitination	EVDLHTAKGRFRAAV EEEEECCCCCEEEEC	52.34	29967540
37	Phosphorylation	RFRAAVPSGASTGIY CEEEECCCCCCCCHH	40.15	21945579
40	Phosphorylation	AAVPSGASTGIYEAL EECCCCCCCCHHHHH	30.60	21945579
41	Phosphorylation	AVPSGASTGIYEALE ECCCCCCCCHHHHHH	27.37	21945579
44	Phosphorylation	SGASTGIYEALELRD CCCCCCHHHHHHCCC	9.11	29255136
50	Methylation	IYEALELRDGDKGRY HHHHHHCCCCCCCCC	36.17	-
57	Nitration	RDGDKGRYLGKGVLK CCCCCCCCCCHHHHH	28.60	-
60	Acetylation	DKGRYLGKGVLKAVE CCCCCCCHHHHHHHH	43.16	19811533
60	Ubiquitination	DKGRYLGKGVLKAVE CCCCCCCHHHHHHHH	43.16	32015554
69	Ubiquitination	VLKAVENINNTLGPA HHHHHHHHCCCCCHH	2.45	32015554
72	Phosphorylation	AVENINNTLGPALLQ HHHHHCCCCCHHHHH	31.11	19764811
83	Phosphorylation	ALLQKKLSVVDQEKV HHHHHHCCCCCHHHH	24.92	19764811
83	Ubiquitination	ALLQKKLSVVDQEKV HHHHHHCCCCCHHHH	24.92	33845483
100	Phosphorylation	FMIELDGTENKSKFG EEEECCCCCCCHHCC	35.73	22673903
103	Ubiquitination	ELDGTENKSKFGANA ECCCCCCCHHCCHHH	49.11	22817900
104	Phosphorylation	LDGTENKSKFGANAI CCCCCCCHHCCHHHH	44.81	22673903
105	Ubiquitination	DGTENKSKFGANAIL CCCCCCHHCCHHHHH	49.80	22817900
112	Ubiquitination	KFGANAILGVSLAVC HCCHHHHHHHHHHHH	5.28	22817900
114	Ubiquitination	GANAILGVSLAVCKA CHHHHHHHHHHHHHH	3.67	22817900
115	Phosphorylation	ANAILGVSLAVCKAG HHHHHHHHHHHHHHC	14.60	-
126	Ubiquitination	CKAGAAEKGVPLYRH HHHCHHHHCCCCHHH	61.55	33845483
131	Phosphorylation	AEKGVPLYRHIADLA HHHCCCCHHHHHHHC	8.28	26356563
131	Nitration	AEKGVPLYRHIADLA HHHCCCCHHHHHHHC	8.28	-
135	Ubiquitination	VPLYRHIADLAGNPD CCCHHHHHHHCCCCC	10.31	33845483
157	Phosphorylation	FNVINGGSHAGNKLA EEEECCCCCCCCHHH	16.15	25850435
159	Ubiquitination	VINGGSHAGNKLAMQ EECCCCCCCCHHHCC	25.58	29967540
176	Phosphorylation	MILPVGASSFKEAMR CEEECCHHHHHHHHH	30.31	28258704
177	Phosphorylation	ILPVGASSFKEAMRI EEECCHHHHHHHHHH	39.54	20068231
189	Nitration	MRIGAEVYHHLKGVI HHHCHHHHHHHHHHH	3.81	-
189	Phosphorylation	MRIGAEVYHHLKGVI HHHCHHHHHHHHHHH	3.81	-
197	Acetylation	HHLKGVIKAKYGKDA HHHHHHHHHHCCCCC	36.10	-
199	Acetylation	LKGVIKAKYGKDATN HHHHHHHHCCCCCCC	49.92	-
200	Nitration	KGVIKAKYGKDATNV HHHHHHHCCCCCCCC	33.98	-
202	Ubiquitination	VIKAKYGKDATNVGD HHHHHCCCCCCCCCC	40.89	29967540
205	Phosphorylation	AKYGKDATNVGDEGG HHCCCCCCCCCCCCC	40.34	-
219	Ubiquitination	GFAPNILENNEALEL CCCCCHHCCHHHHHH	54.97	22817900
229	Phosphorylation	EALELLKTAIQAAGY HHHHHHHHHHHHCCC	29.03	26437602
232	Ubiquitination	ELLKTAIQAAGYPDK HHHHHHHHHCCCCCE	23.77	29967540
236	Nitration	TAIQAAGYPDKVVIG HHHHHCCCCCEEEEE	11.97	-
236	Phosphorylation	TAIQAAGYPDKVVIG HHHHHCCCCCEEEEE	11.97	26437602
238	Ubiquitination	IQAAGYPDKVVIGMD HHHCCCCCEEEEEEE	48.15	29967540
252	Phosphorylation	DVAASEFYRNGKYDL EEEHHHHHHCCCCCC	10.10	-
257	Phosphorylation	EFYRNGKYDLDFKSP HHHHCCCCCCCCCCC	24.12	-
257	Nitration	EFYRNGKYDLDFKSP HHHHCCCCCCCCCCC	24.12	-
262	Acetylation	GKYDLDFKSPDDPAR CCCCCCCCCCCCHHH	61.82	30588491
262	Ubiquitination	GKYDLDFKSPDDPAR CCCCCCCCCCCCHHH	61.82	22817900
263	Phosphorylation	KYDLDFKSPDDPARH CCCCCCCCCCCHHHH	33.29	11506403
271	Ubiquitination	PDDPARHITGEKLGE CCCHHHHCCHHHHHH	4.39	22817900
275	Ubiquitination	ARHITGEKLGELYKS HHHCCHHHHHHHHHH	64.24	29967540
280	Nitration	GEKLGELYKSFIKNY HHHHHHHHHHHHHCC	10.57	-
281	Ubiquitination	EKLGELYKSFIKNYP HHHHHHHHHHHHCCC	52.06	29967540
282	Phosphorylation	KLGELYKSFIKNYPV HHHHHHHHHHHCCCE	20.74	19764811
287	Nitration	YKSFIKNYPVVSIED HHHHHHCCCEEECCC	7.75	-
287	Phosphorylation	YKSFIKNYPVVSIED HHHHHHCCCEEECCC	7.75	-
300	Ubiquitination	EDPFDQDDWATWTSF CCCCCCCHHHHHHHH	31.14	22817900
326	Ubiquitination	DLTVTNPKRIAQAVE CCCCCCHHHHHHHHH	59.51	-
343	Ubiquitination	ACNCLLLKVNQIGSV HHCEEEEEHHHCCCH	38.82	22817900
349	Phosphorylation	LKVNQIGSVTESIQA EEHHHCCCHHHHHHH	27.74	28857561
351	Phosphorylation	VNQIGSVTESIQACK HHHCCCHHHHHHHHH	26.22	28857561
351	Ubiquitination	VNQIGSVTESIQACK HHHCCCHHHHHHHHH	26.22	21963094
352	Ubiquitination	NQIGSVTESIQACKL HHCCCHHHHHHHHHH	43.63	22817900
353	Phosphorylation	QIGSVTESIQACKLA HCCCHHHHHHHHHHH	15.61	21712546
357	Glutathionylation	VTESIQACKLAQSNG HHHHHHHHHHHHHCC	1.81	22555962
357	S-nitrosylation	VTESIQACKLAQSNG HHHHHHHHHHHHHCC	1.81	2212679
358	Acetylation	TESIQACKLAQSNGW HHHHHHHHHHHHCCC	50.28	26051181
358	Ubiquitination	TESIQACKLAQSNGW HHHHHHHHHHHHCCC	50.28	-
362	Phosphorylation	QACKLAQSNGWGVMV HHHHHHHHCCCEEEE	31.53	26437602
363	Ubiquitination	ACKLAQSNGWGVMVS HHHHHHHCCCEEEEE	37.85	24816145
370	Phosphorylation	NGWGVMVSHRSGETE CCCEEEEECCCCCCC	8.62	-
373	Phosphorylation	GVMVSHRSGETEDTF EEEEECCCCCCCCCH	35.24	30278072
376	Phosphorylation	VSHRSGETEDTFIAD EECCCCCCCCCHHHH	42.56	30278072
377	Ubiquitination	SHRSGETEDTFIADL ECCCCCCCCCHHHHH	51.23	29967540
379	Phosphorylation	RSGETEDTFIADLVV CCCCCCCCHHHHHHH	15.65	30278072
390	Phosphorylation	DLVVGLCTGQIKTGA HHHHHHHCCCCCCCC	36.84	28060719
394	Ubiquitination	GLCTGQIKTGAPCRS HHHCCCCCCCCCCCH	32.78	21963094
395	Phosphorylation	LCTGQIKTGAPCRSE HHCCCCCCCCCCCHH	39.96	23882029
403	Ubiquitination	GAPCRSERLAKYNQL CCCCCHHHHHHHHHH	40.99	21963094
406	Ubiquitination	CRSERLAKYNQLMRI CCHHHHHHHHHHHHH	49.69	24816145
407	Nitration	RSERLAKYNQLMRIE CHHHHHHHHHHHHHH	11.52	-
415	Ubiquitination	NQLMRIEEALGDKAI HHHHHHHHHHCCCHH	46.99	24816145
420	Ubiquitination	IEEALGDKAIFAGRK HHHHHCCCHHHCCCC	41.40	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENOB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENOB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENOB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KPYM_HUMAN	PKM	physical	22939629
G6PI_HUMAN	GPI	physical	22939629
ALDR_HUMAN	AKR1B1	physical	26344197
ATP5J_HUMAN	ATP5J	physical	26344197
CALR_HUMAN	CALR	physical	26344197
CATA_HUMAN	CAT	physical	26344197
DUT_HUMAN	DUT	physical	26344197
EF1A1_HUMAN	EEF1A1	physical	26344197
ENOG_HUMAN	ENO2	physical	26344197
FABP5_HUMAN	FABP5	physical	26344197
FKB1A_HUMAN	FKBP1A	physical	26344197
FKB1B_HUMAN	FKBP1B	physical	26344197
CH10_HUMAN	HSPE1	physical	26344197
PDIA1_HUMAN	P4HB	physical	26344197
PGAM1_HUMAN	PGAM1	physical	26344197
PUS7_HUMAN	PUS7	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
THIO_HUMAN	TXN	physical	26344197
ENOA_HUMAN	ENO1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 612932: Glycogen storage disease 13 (GSD13)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.