dbPTM

PUS7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUS7_HUMAN
UniProt AC	Q96PZ0
Protein Name	Pseudouridylate synthase 7 homolog {ECO:0000305}
Gene Name	PUS7 {ECO:0000312\|HGNC:HGNC:26033}
Organism	Homo sapiens (Human).
Sequence Length	661
Subcellular Localization	Nucleus .
Protein Description	Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. [PubMed: 28073919]
Protein Sequence	MEMTEMTGVSLKRGALVVEDNDSGVPVEETKKQKLSECSLTKGQDGLQNDFLSISEDVPRPPDTVSTGKGGKNSEAQLEDEEEEEEDGLSEECEEEESESFADMMKHGLTEADVGITKFVSSHQGFSGILKERYSDFVVHEIGKDGRISHLNDLSIPVDEEDPSEDIFTVLTAEEKQRLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGKKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDDQVQQAMNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWTEVMDLILKPRSGAEKGYLVKCREEWAKTKDPTAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIEDYGLKPVPGDLVLKGATATYIEEDDVNNYSIHDVVMPLPGFDVIYPKHKIQEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTDVDNLEGKTPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTTWLR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEMTEMTG -------CCCCCCCC	7.78	22814378
4	O-linked_Glycosylation	----MEMTEMTGVSL ----CCCCCCCCEEE	14.86	30379171
10	Phosphorylation	MTEMTGVSLKRGALV CCCCCCEEEECCEEE	29.53	24114839
13	Methylation	MTGVSLKRGALVVED CCCEEEECCEEEEEE	40.69	115489675
23	Phosphorylation	LVVEDNDSGVPVEET EEEEECCCCCCCHHH	48.20	25159151
31	Acetylation	GVPVEETKKQKLSEC CCCCHHHHHCCHHHC	57.39	26051181
36	Phosphorylation	ETKKQKLSECSLTKG HHHHCCHHHCCCCCC	43.52	20873877
39	Phosphorylation	KQKLSECSLTKGQDG HCCHHHCCCCCCCCC	34.71	21815630
41	Phosphorylation	KLSECSLTKGQDGLQ CHHHCCCCCCCCCCC	19.48	25850435
53	Phosphorylation	GLQNDFLSISEDVPR CCCCCCCCCCCCCCC	24.86	27251275
55	Phosphorylation	QNDFLSISEDVPRPP CCCCCCCCCCCCCCC	25.11	28348404
64	Phosphorylation	DVPRPPDTVSTGKGG CCCCCCCCCCCCCCC	23.33	25159151
66	Phosphorylation	PRPPDTVSTGKGGKN CCCCCCCCCCCCCCC	33.27	30576142
67	Phosphorylation	RPPDTVSTGKGGKNS CCCCCCCCCCCCCCC	38.28	27732954
69	Acetylation	PDTVSTGKGGKNSEA CCCCCCCCCCCCCCC	65.66	25953088
74	Phosphorylation	TGKGGKNSEAQLEDE CCCCCCCCCCCCCCH	37.48	30576142
90	Phosphorylation	EEEEDGLSEECEEEE HHHHCCCCHHHHHHH	36.56	27422710
98	Phosphorylation	EECEEEESESFADMM HHHHHHHHHHHHHHH	41.65	22210691
100	Phosphorylation	CEEEESESFADMMKH HHHHHHHHHHHHHHC	34.71	22210691
118	Acetylation	EADVGITKFVSSHQG HHHHCHHHHHHCCCC	41.68	26051181
121	Phosphorylation	VGITKFVSSHQGFSG HCHHHHHHCCCCCCH	25.82	25159151
122	Phosphorylation	GITKFVSSHQGFSGI CHHHHHHCCCCCCHH	17.96	25627689
127	Phosphorylation	VSSHQGFSGILKERY HHCCCCCCHHHHHHH	31.58	25159151
131	Acetylation	QGFSGILKERYSDFV CCCCHHHHHHHCCEE	37.92	19608861
134	Phosphorylation	SGILKERYSDFVVHE CHHHHHHHCCEEEEE	17.43	29214152
135	Phosphorylation	GILKERYSDFVVHEI HHHHHHHCCEEEEEC	30.69	28555341
144	Ubiquitination	FVVHEIGKDGRISHL EEEEECCCCCCCEEC	63.77	-
144	Acetylation	FVVHEIGKDGRISHL EEEEECCCCCCCEEC	63.77	25953088
155	Phosphorylation	ISHLNDLSIPVDEED CEECCCCCCCCCCCC	27.92	25159151
176	Ubiquitination	TVLTAEEKQRLEELQ EEEEHHHHHHHHHHH	32.02	21890473
190	Phosphorylation	QLFKNKETSVAIEVI HHHCCCCCCEEEEEE	30.06	26074081
191	Phosphorylation	LFKNKETSVAIEVIE HHCCCCCCEEEEEEC	15.61	26074081
200	Phosphorylation	AIEVIEDTKEKRTII EEEEECCCCHHHHHH	28.45	26074081
213	Phosphorylation	IIHQAIKSLFPGLET HHHHHHHHHCCCCCC	29.18	21406692
220	Phosphorylation	SLFPGLETKTEDREG HHCCCCCCCCCCCCC	48.59	21406692
221	Ubiquitination	LFPGLETKTEDREGK HCCCCCCCCCCCCCC	40.31	-
230	Phosphorylation	EDREGKKYIVAYHAA CCCCCCEEEEEEECC	12.24	20068231
234	Phosphorylation	GKKYIVAYHAAGKKA CCEEEEEEECCCHHH	4.90	20068231
239	Acetylation	VAYHAAGKKALANPR EEEECCCHHHHCCCC	30.10	26051181
249	Phosphorylation	LANPRKHSWPKSRGS HCCCCCCCCCCCCCC	48.38	26091039
254	Methylation	KHSWPKSRGSYCHFV CCCCCCCCCCEEEEE	44.17	115489683
263	Phosphorylation	SYCHFVLYKENKDTM CEEEEEEEECCCCHH	15.79	22817900
269	Phosphorylation	LYKENKDTMDAINVL EEECCCCHHHHHHHH	20.68	29116813
270	Sulfoxidation	YKENKDTMDAINVLS EECCCCHHHHHHHHH	4.74	21406390
277	Phosphorylation	MDAINVLSKYLRVKP HHHHHHHHHHHCCCC	18.25	29116813
278	Ubiquitination	DAINVLSKYLRVKPN HHHHHHHHHHCCCCC	44.11	21906983
279	Phosphorylation	AINVLSKYLRVKPNI HHHHHHHHHCCCCCC	9.07	29116813
292	Phosphorylation	NIFSYMGTKDKRAIT CCHHHCCCCCCCCEE	21.38	29116813
318	Acetylation	QRLAHLNKCLMNFKL HHHHHHHHHHHHCCC	34.80	25953088
318	Ubiquitination	QRLAHLNKCLMNFKL HHHHHHHHHHHHCCC	34.80	21906983
324	Ubiquitination	NKCLMNFKLGNFSYQ HHHHHHCCCCCCCCC	50.94	21906983
332	Ubiquitination	LGNFSYQKNPLKLGE CCCCCCCCCCCCCCC	52.91	-
353	Phosphorylation	TVVLRNITGTDDQVQ EEEEEECCCCHHHHH	37.26	21406692
355	Phosphorylation	VLRNITGTDDQVQQA EEEECCCCHHHHHHH	27.96	21406692
365	Phosphorylation	QVQQAMNSLKEIGFI HHHHHHHHHHHHCCE	27.94	21406692
403	Sulfoxidation	QNSWTEVMDLILKPR HCCHHHHHHHHHCCC	2.56	28183972
411	Phosphorylation	DLILKPRSGAEKGYL HHHHCCCCCCCCCEE	51.38	22210691
415	Ubiquitination	KPRSGAEKGYLVKCR CCCCCCCCCEEEEEH	52.93	-
420	Ubiquitination	AEKGYLVKCREEWAK CCCCEEEEEHHHHHH	25.61	-
450	Methylation	CVEGQLLRGLSKYGM HHHHHHHHHHHHHCC	53.23	30988967
455	Phosphorylation	LLRGLSKYGMKNIVS HHHHHHHHCCCHHHH	21.05	23532336
462	Phosphorylation	YGMKNIVSAFGIIPR HCCCHHHHHHCEECC	17.68	22199227
475	Phosphorylation	PRNNRLMYIHSYQSY CCCCEEEEEEEEHHH	10.48	-
479	Phosphorylation	RLMYIHSYQSYVWNN EEEEEEEEHHHHHHH	6.31	-
482	Phosphorylation	YIHSYQSYVWNNMVS EEEEEHHHHHHHHHC	8.24	-
495	Phosphorylation	VSKRIEDYGLKPVPG HCHHHHHCCCCCCCC	16.15	-
542	Ubiquitination	DVIYPKHKIQEAYRE CEEECHHHHHHHHHH	52.81	-
550	Sulfoxidation	IQEAYREMLTADNLD HHHHHHHHHHCCCCC	2.74	21406390
568	Phosphorylation	MRHKIRDYSLSGAYR HHHHHHHCCCCCCEE	11.15	20068231
569	Phosphorylation	RHKIRDYSLSGAYRK HHHHHHCCCCCCEEE	21.98	20068231
571	Phosphorylation	KIRDYSLSGAYRKII HHHHCCCCCCEEEEE	18.55	20068231
574	Phosphorylation	DYSLSGAYRKIIIRP HCCCCCCEEEEEECC	18.90	20068231
585	Phosphorylation	IIRPQNVSWEVVAYD EECCCCEEEEEEEEC	25.68	22210691
601	Phosphorylation	PKIPLFNTDVDNLEG CCCCCCCCCCHHCCC	30.02	28176443
609	Sumoylation	DVDNLEGKTPPVFAS CCHHCCCCCCCCCCC	48.78	-
609	Ubiquitination	DVDNLEGKTPPVFAS CCHHCCCCCCCCCCC	48.78	-
610	Phosphorylation	VDNLEGKTPPVFASE CHHCCCCCCCCCCCC	43.62	29255136
616	Phosphorylation	KTPPVFASEGKYRAL CCCCCCCCCCCEEEE	35.10	28176443
619	Sumoylation	PVFASEGKYRALKMD CCCCCCCCEEEEECC	27.75	-
619	Sumoylation	PVFASEGKYRALKMD CCCCCCCCEEEEECC	27.75	-
619	Ubiquitination	PVFASEGKYRALKMD CCCCCCCCEEEEECC	27.75	-
619	Acetylation	PVFASEGKYRALKMD CCCCCCCCEEEEECC	27.75	23954790
628	Phosphorylation	RALKMDFSLPPSTYA EEEECCCCCCHHHHH	35.38	-
648	Phosphorylation	EVLKMDTSIKNQTQL HHHCCCCCCCCCCCC	27.57	25003641
657	Phosphorylation	KNQTQLNTTWLR--- CCCCCCCCCCCC---	28.13	23186163
658	Phosphorylation	NQTQLNTTWLR---- CCCCCCCCCCC----	22.79	25159151
661	Methylation	QLNTTWLR------- CCCCCCCC-------	35.73	115489667

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUS7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUS7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUS7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR74_HUMAN	WDR74	physical	22939629
HS105_HUMAN	HSPH1	physical	22863883
STAT3_HUMAN	STAT3	physical	22863883
ACO13_HUMAN	ACOT13	physical	26344197
ACTN4_HUMAN	ACTN4	physical	26344197
BYST_HUMAN	BYSL	physical	26344197
DDX3X_HUMAN	DDX3X	physical	26344197
DHX15_HUMAN	DHX15	physical	26344197
DHX16_HUMAN	DHX16	physical	26344197
DOHH_HUMAN	DOHH	physical	26344197
IF4G1_HUMAN	EIF4G1	physical	26344197
IF4G3_HUMAN	EIF4G3	physical	26344197
ENOPH_HUMAN	ENOPH1	physical	26344197
MCM3_HUMAN	MCM3	physical	26344197
MCM5_HUMAN	MCM5	physical	26344197
NH2L1_HUMAN	NHP2L1	physical	26344197
NOC3L_HUMAN	NOC3L	physical	26344197
NSUN2_HUMAN	NSUN2	physical	26344197
RPB4_HUMAN	POLR2D	physical	26344197
RPB7_HUMAN	POLR2G	physical	26344197
RBM8A_HUMAN	RBM8A	physical	26344197
LA_HUMAN	SSB	physical	26344197
ZO2_HUMAN	TJP2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUS7_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-131, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-610, AND MASSSPECTROMETRY.	19690332 [Abstract]