DOHH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOHH_HUMAN
• UniProt AC: Q9BU89
• Protein Name: Deoxyhypusine hydroxylase {ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000303|PubMed:16533814}
• Gene Name: DOHH {ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000312|HGNC:HGNC:28662}
• Organism: Homo sapiens (Human).
• Sequence Length: 302
• Protein Description: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. [PubMed: 16533814]
• Protein Sequence: MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVTEQEVD -------CCCHHHHH	8.31	22223895
18	Ubiquitination	GQTLVDPKQPLQARF HCCCCCCCCCHHHHH	61.15	24816145
30	Phosphorylation	ARFRALFTLRGLGGP HHHHHHHHHCCCCCC	19.18	24719451
44	Phosphorylation	PGAIAWISQAFDDDS CCHHHHHHHHCCCCH	12.54	-
81	Phosphorylation	LVDVLQDTRQEPMVR HHHHHHHCCCCCCHH	22.69	21406692
144	Phosphorylation	GEPAAGPYLSVDPAP CCCCCCCCCCCCCCC	15.64	28796482
200	Glutathionylation	ALAEGLHCGSALFRH HHHHCCCCCHHHHHH	5.76	22555962
200	S-nitrosylation	ALAEGLHCGSALFRH HHHHCCCCCHHHHHH	5.76	24105792
242	S-nitrosylation	NPMVRHECAEALGAI CHHHHHHHHHHHHHH	3.20	24105792
254	S-nitrosylation	GAIARPACLAALQAH HHHHHHHHHHHHHHC	2.70	24105792
272	Phosphorylation	PERVVRESCEVALDM HHHHHHHHHHHHHHH	12.66	28796482
273	Glutathionylation	ERVVRESCEVALDMY HHHHHHHHHHHHHHH	4.12	22555962
273	S-nitrosylation	ERVVRESCEVALDMY HHHHHHHHHHHHHHH	4.12	24105792
280	Phosphorylation	CEVALDMYEHETGRA HHHHHHHHHCCCCCC	17.50	28796482
284	Phosphorylation	LDMYEHETGRAFQYA HHHHHCCCCCCHHHH	33.60	28796482
290	Phosphorylation	ETGRAFQYADGLEQL CCCCCHHHHHHHHHH	10.54	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOHH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOHH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOHH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IDE_HUMAN	IDE	physical	26186194
IF5A2_HUMAN	EIF5A2	physical	26186194
IF5A1_HUMAN	EIF5A	physical	26186194
SK2L2_HUMAN	SKIV2L2	physical	26344197
IF5A2_HUMAN	EIF5A2	physical	28514442
IF5A1_HUMAN	EIF5A	physical	28514442
IDE_HUMAN	IDE	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.