dbPTM

S23IP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	S23IP_HUMAN
UniProt AC	Q9Y6Y8
Protein Name	SEC23-interacting protein
Gene Name	SEC23IP
Organism	Homo sapiens (Human).
Sequence Length	1000
Subcellular Localization	Cytoplasmic vesicle, COPII-coated vesicle membrane Peripheral membrane protein Cytoplasmic side. Endoplasmic reticulum .
Protein Description	Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P)..
Protein Sequence	MAERKPNGGSGGASTSSSGTNLLFSSSATEFSFNVPFIPVTQASASPASLLLPGEDSTDVGEEDSFLGQTSIHTSAPQTFSYFSQVSSSSDPFGNIGQSPLTTAATSVGQSGFPKPLTALPFTTGSQDVSNAFSPSISKAQPGAPPSSLMGINSYLPSQPSSLPPSYFGNQPQGIPQPGYNPYRHTPGSSRANPYIAPPQLQQCQTPGPPAHPPPSGPPVQMYQMPPGSLPPVPSSVQSPAQQQVPARPGAPSVQVPSPFLLQNQYEPVQPHWFYCKEVEYKQLWMPFSVFDSLNLEEIYNSVQPDPESVVLGTDGGRYDVYLYDRIRKAAYWEEEPAEVRRCTWFYKGDTDSRFIPYTEEFSEKLEAEYKKAVTTNQWHRRLEFPSGETIVMHNPKVIVQFQPSSVPDEWGTTQDGQTRPRVVKRGIDDNLDEIPDGEMPQVDHLVFVVHGIGPVCDLRFRSIIECVDDFRVVSLKLLRTHFKKSLDDGKVSRVEFLPVHWHSSLGGDATGVDRNIKKITLPSIGRFRHFTNETLLDILFYNSPTYCQTIVEKVGMEINHLHALFMSRNPDFKGGVSVAGHSLGSLILFDILSNQKDLNLSKCPGPLAVANGVVKQLHFQEKQMPEEPKLTLDESYDLVVENKEVLTLQETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTALLLLKEIYRTMNISPEQPQH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	O-linked_Glycosylation	SSSATEFSFNVPFIP CCCCCEEEEECCEEC	15.07	30059200
41	O-linked_Glycosylation	NVPFIPVTQASASPA ECCEECCCCCCCCCH	17.05	30059200
44	O-linked_Glycosylation	FIPVTQASASPASLL EECCCCCCCCCHHEE	21.33	30059200
49	O-linked_Glycosylation	QASASPASLLLPGED CCCCCCHHEECCCCC	23.96	30059200
87	O-linked_Glycosylation	FSYFSQVSSSSDPFG EHHHEECCCCCCCCC	19.50	30059200
88	O-linked_Glycosylation	SYFSQVSSSSDPFGN HHHEECCCCCCCCCC	34.70	30059200
90	O-linked_Glycosylation	FSQVSSSSDPFGNIG HEECCCCCCCCCCCC	51.77	30059200
103	O-linked_Glycosylation	IGQSPLTTAATSVGQ CCCCCCCCCHHCCCC	23.21	30059200
106	O-linked_Glycosylation	SPLTTAATSVGQSGF CCCCCCHHCCCCCCC	22.83	30059200
107	O-linked_Glycosylation	PLTTAATSVGQSGFP CCCCCHHCCCCCCCC	21.37	30059200
111	O-linked_Glycosylation	AATSVGQSGFPKPLT CHHCCCCCCCCCCCE	36.15	30059200
118	O-linked_Glycosylation	SGFPKPLTALPFTTG CCCCCCCEECCCCCC	34.37	30059200
123	O-linked_Glycosylation	PLTALPFTTGSQDVS CCEECCCCCCCCCHH	28.45	30059200
123	Phosphorylation	PLTALPFTTGSQDVS CCEECCCCCCCCCHH	28.45	26074081
124	O-linked_Glycosylation	LTALPFTTGSQDVSN CEECCCCCCCCCHHH	34.90	30059200
124	Phosphorylation	LTALPFTTGSQDVSN CEECCCCCCCCCHHH	34.90	26074081
126	O-linked_Glycosylation	ALPFTTGSQDVSNAF ECCCCCCCCCHHHHC	22.55	30059200
126	Phosphorylation	ALPFTTGSQDVSNAF ECCCCCCCCCHHHHC	22.55	26074081
130	O-linked_Glycosylation	TTGSQDVSNAFSPSI CCCCCCHHHHCCCCC	30.63	30059200
130	Phosphorylation	TTGSQDVSNAFSPSI CCCCCCHHHHCCCCC	30.63	29255136
134	O-linked_Glycosylation	QDVSNAFSPSISKAQ CCHHHHCCCCCHHCC	18.48	30059200
134	Phosphorylation	QDVSNAFSPSISKAQ CCHHHHCCCCCHHCC	18.48	29255136
136	O-linked_Glycosylation	VSNAFSPSISKAQPG HHHHCCCCCHHCCCC	37.99	30059200
136	Phosphorylation	VSNAFSPSISKAQPG HHHHCCCCCHHCCCC	37.99	29255136
138	O-linked_Glycosylation	NAFSPSISKAQPGAP HHCCCCCHHCCCCCC	26.69	30059200
138	Phosphorylation	NAFSPSISKAQPGAP HHCCCCCHHCCCCCC	26.69	29255136
155	Phosphorylation	SLMGINSYLPSQPSS HHCCCHHCCCCCCCC	20.39	27251275
158	Phosphorylation	GINSYLPSQPSSLPP CCHHCCCCCCCCCCC	52.72	27251275
161	Phosphorylation	SYLPSQPSSLPPSYF HCCCCCCCCCCCHHH	36.55	27251275
162	Phosphorylation	YLPSQPSSLPPSYFG CCCCCCCCCCCHHHC	52.13	27251275
184	Methylation	QPGYNPYRHTPGSSR CCCCCCCCCCCCCCC	28.58	115389643
186	O-linked_Glycosylation	GYNPYRHTPGSSRAN CCCCCCCCCCCCCCC	21.98	30059200
190	O-linked_Glycosylation	YRHTPGSSRANPYIA CCCCCCCCCCCCCCC	41.13	30059200
258	Phosphorylation	APSVQVPSPFLLQNQ CCCCCCCCCCHHCCC	29.45	25159151
282	Ubiquitination	YCKEVEYKQLWMPFS EEEECEEEEEECCHH	25.96	22817900
326	Methylation	YDVYLYDRIRKAAYW EEEEEHHHHHHHHHC	19.63	115493527
329	Ubiquitination	YLYDRIRKAAYWEEE EEHHHHHHHHHCCCC	34.69	21906983
329 (in isoform 1)	Ubiquitination	-	34.69	21890473
329 (in isoform 2)	Ubiquitination	-	34.69	21890473
348	Ubiquitination	RRCTWFYKGDTDSRF EECEEEECCCCCCCE	40.62	29967540
365	Ubiquitination	YTEEFSEKLEAEYKK CCHHHHHHHHHHHHH	50.89	33845483
372	Ubiquitination	KLEAEYKKAVTTNQW HHHHHHHHCCCCCCH	47.38	29967540
387	Phosphorylation	HRRLEFPSGETIVMH HHCCCCCCCCEEEEE	55.36	20068231
390	Phosphorylation	LEFPSGETIVMHNPK CCCCCCCEEEEECCE	23.54	21406692
406	Phosphorylation	IVQFQPSSVPDEWGT EEEECCCCCCCCCCC	44.33	28555341
430	Ubiquitination	VVKRGIDDNLDEIPD CCCCCCCCCCCCCCC	56.52	21890473
438	Ubiquitination	NLDEIPDGEMPQVDH CCCCCCCCCCCCCCE	27.96	24816145
467	Glutathionylation	RFRSIIECVDDFRVV HHHHHHHHCCHHHHH	2.61	22555962
477	Acetylation	DFRVVSLKLLRTHFK HHHHHHHHHHHHHHH	37.66	25953088
477	Ubiquitination	DFRVVSLKLLRTHFK HHHHHHHHHHHHHHH	37.66	22817900
477 (in isoform 1)	Ubiquitination	-	37.66	21890473
477 (in isoform 2)	Ubiquitination	-	37.66	21890473
484	Methylation	KLLRTHFKKSLDDGK HHHHHHHHHHCCCCC	33.57	6570003
485	Ubiquitination	LLRTHFKKSLDDGKV HHHHHHHHHCCCCCC	56.14	24816145
486	O-linked_Glycosylation	LRTHFKKSLDDGKVS HHHHHHHHCCCCCCC	37.31	30059200
491	Ubiquitination	KKSLDDGKVSRVEFL HHHCCCCCCCEEEEE	43.99	33845483
602	Phosphorylation	NQKDLNLSKCPGPLA CCCCCCCCCCCCHHH	31.01	29214152
603	Ubiquitination	QKDLNLSKCPGPLAV CCCCCCCCCCCHHHH	47.84	32015554
623	Ubiquitination	KQLHFQEKQMPEEPK EEHHHCCCCCCCCCC	40.91	29967540
636	Phosphorylation	PKLTLDESYDLVVEN CCCCCCCCCCEEECC	24.50	29978859
637	Phosphorylation	KLTLDESYDLVVENK CCCCCCCCCEEECCC	15.96	29978859
648	Phosphorylation	VENKEVLTLQETLEA ECCCCEEEHHHHHHH	31.41	20068231
674	Phosphorylation	KEKIDMESLLMCTVD HHCCCHHHHEECCHH	21.84	29449344
676	Ubiquitination	KIDMESLLMCTVDDL CCCHHHHEECCHHHH	3.54	22817900
679	Phosphorylation	MESLLMCTVDDLKEM HHHHEECCHHHHHHC	17.01	29449344
695	Ubiquitination	IPLGPRKKIANFVEH CCCCCHHHHHHHHHH	48.61	29967540
703	Ubiquitination	IANFVEHKAAKLKKA HHHHHHHHHHHHHHH	36.21	29967540
706	Ubiquitination	FVEHKAAKLKKAASE HHHHHHHHHHHHHHH	66.74	-
712	Phosphorylation	AKLKKAASEKKAVAA HHHHHHHHHHCHHHH	55.60	23911959
720	Phosphorylation	EKKAVAATSTKGQEQ HHCHHHHHCCCCHHH	27.47	18452278
722	Phosphorylation	KAVAATSTKGQEQSA CHHHHHCCCCHHHHH	34.53	18452278
723	Ubiquitination	AVAATSTKGQEQSAQ HHHHHCCCCHHHHHH	59.36	21906983
723 (in isoform 1)	Ubiquitination	-	59.36	21890473
723 (in isoform 2)	Ubiquitination	-	59.36	21890473
728	Phosphorylation	STKGQEQSAQKTKDM CCCCHHHHHHHHHHH	31.73	26074081
733	Ubiquitination	EQSAQKTKDMASLPS HHHHHHHHHHHHCCC	53.17	33845483
737	Phosphorylation	QKTKDMASLPSESNE HHHHHHHHCCCCCCC	33.89	28355574
740	Phosphorylation	KDMASLPSESNEPKR HHHHHCCCCCCCCCC	59.97	25159151
742	Phosphorylation	MASLPSESNEPKRKL HHHCCCCCCCCCCCC	51.32	25159151
746	Acetylation	PSESNEPKRKLPVGA CCCCCCCCCCCCCCC	56.86	26051181
746	Ubiquitination	PSESNEPKRKLPVGA CCCCCCCCCCCCCCC	56.86	33845483
815	Ubiquitination	NYSLPTCKGFFNIYH CCCCCCCCCCCEECC	62.32	-
832	Ubiquitination	DPVAYRLEPMIVPDL CHHHHCCCCCCCCCC	24.67	22817900
834	Sulfoxidation	VAYRLEPMIVPDLDL HHHCCCCCCCCCCCC	3.35	30846556
850	Ubiquitination	AVLIPHHKGRKRLHL EEEEECCCCCCHHHH	58.33	29967540
860	Ubiquitination	KRLHLELKESLSRMG CHHHHHHHHHHHHHC	35.56	33845483
862	Phosphorylation	LHLELKESLSRMGSD HHHHHHHHHHHHCHH	30.02	30108239
863	Ubiquitination	HLELKESLSRMGSDL HHHHHHHHHHHCHHH	3.84	22817900
864	Phosphorylation	LELKESLSRMGSDLK HHHHHHHHHHCHHHH	29.51	30108239
868	Phosphorylation	ESLSRMGSDLKQGFI HHHHHHCHHHHHHHH	30.35	24719451
868	Ubiquitination	ESLSRMGSDLKQGFI HHHHHHCHHHHHHHH	30.35	22817900
871	Ubiquitination	SRMGSDLKQGFISSL HHHCHHHHHHHHHHH	54.06	33845483
876	Phosphorylation	DLKQGFISSLKSAWQ HHHHHHHHHHHHHHH	27.62	24719451
879	Ubiquitination	QGFISSLKSAWQTLN HHHHHHHHHHHHHHH	39.82	21906983
879 (in isoform 1)	Ubiquitination	-	39.82	21890473
879 (in isoform 2)	Ubiquitination	-	39.82	21890473
883	Ubiquitination	SSLKSAWQTLNEFAR HHHHHHHHHHHHHHH	35.51	22817900
884	Ubiquitination	SLKSAWQTLNEFARA HHHHHHHHHHHHHHH	22.35	22817900
890	Ubiquitination	QTLNEFARAHTSSTQ HHHHHHHHHHCCHHH	32.02	21890473
891	Ubiquitination	TLNEFARAHTSSTQL HHHHHHHHHCCHHHH	13.59	21890473
893	Phosphorylation	NEFARAHTSSTQLQE HHHHHHHCCHHHHHH	24.32	26657352
894	Phosphorylation	EFARAHTSSTQLQEE HHHHHHCCHHHHHHH	22.86	27050516
895	Phosphorylation	FARAHTSSTQLQEEL HHHHHCCHHHHHHHH	22.71	26657352
896	Phosphorylation	ARAHTSSTQLQEELE HHHHCCHHHHHHHHH	32.82	28857561
904	Ubiquitination	QLQEELEKVANQIKE HHHHHHHHHHHHHHH	60.31	33845483
910	Ubiquitination	EKVANQIKEEEEKQV HHHHHHHHHHHHHHH	49.67	21906983
910 (in isoform 1)	Ubiquitination	-	49.67	21890473
910 (in isoform 2)	Ubiquitination	-	49.67	21890473
915	Ubiquitination	QIKEEEEKQVVEAEK HHHHHHHHHHHHHEH	52.23	33845483
922	Ubiquitination	KQVVEAEKVVESPDF HHHHHHEHHHCCCCC	59.64	33845483
926	Phosphorylation	EAEKVVESPDFSKDE HHEHHHCCCCCCCCC	20.40	29255136
930	Phosphorylation	VVESPDFSKDEDYLG HHCCCCCCCCCCHHH	46.72	30266825
930	Ubiquitination	VVESPDFSKDEDYLG HHCCCCCCCCCCHHH	46.72	22817900
931	2-Hydroxyisobutyrylation	VESPDFSKDEDYLGK HCCCCCCCCCCHHHC	66.19	-
931	Ubiquitination	VESPDFSKDEDYLGK HCCCCCCCCCCHHHC	66.19	21906983
931 (in isoform 1)	Ubiquitination	-	66.19	21890473
935	Phosphorylation	DFSKDEDYLGKVGML CCCCCCCHHHCEECC	18.46	23927012
937	Ubiquitination	SKDEDYLGKVGMLNG CCCCCHHHCEECCCC	19.17	21890473
938	Ubiquitination	KDEDYLGKVGMLNGG CCCCHHHCEECCCCC	32.78	22817900
938 (in isoform 1)	Ubiquitination	-	32.78	21890473
994	Phosphorylation	IYRTMNISPEQPQH- HHHHCCCCCCCCCC-	19.85	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of S23IP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of S23IP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of S23IP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPM3_HUMAN	TPM3	physical	22939629
URM1_HUMAN	URM1	physical	22939629
Z518B_HUMAN	ZNF518B	physical	22939629
XIAP_HUMAN	XIAP	physical	22939629
SSU72_HUMAN	SSU72	physical	22939629
TBC13_HUMAN	TBC1D13	physical	22939629
UBE2H_HUMAN	UBE2H	physical	22939629
ZN593_HUMAN	ZNF593	physical	22939629
TPIS_HUMAN	TPI1	physical	22939629
SEP11_HUMAN	SEPT11	physical	22863883
IFT25_HUMAN	HSPB11	physical	25416956
SRCRL_HUMAN	SSC5D	physical	25416956
HSP74_HUMAN	HSPA4	physical	26344197
NCBP1_HUMAN	NCBP1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of S23IP_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-926, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-926, AND MASSSPECTROMETRY.	18669648 [Abstract]