Z518B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: Z518B_HUMAN
• UniProt AC: Q9C0D4
• Protein Name: Zinc finger protein 518B
• Gene Name: ZNF518B
• Organism: Homo sapiens (Human).
• Sequence Length: 1074
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MKDIGQQLYTTHLNGGHNSLTMSPKQPDANGAPRPNRQEAQTLLYQGSEAEAAMMTIATCAKCKSVHKISLQDLQKGTGKDGMYVCFQCSLGAAPPNFHFVSNNSSATHVGNKTENFSSSVNSKFKVRNFKPGKYYCDKCRFSTKDPLQYKKHTLQHEEIKFICSHCSYISYTKGEFQRHLVKHTGIFPYQCEYCDYGAIRNDYIVKHTKRVHERAGAKRPVKAVAKLEPKRTGTSKQNPELLKASNPRTTFQNKWSDQLSGFSLHANKDKMHNIMLLPEPKEYQKDVVCIPNKMTLSEPNEVNLFENKNVEVEVLSPAKEPVQPGMPLTVVAPAELVVPANCLAQLIDVKVVNGTQQLVLKLFPLEENNCLEAGRDNGGNSERMVKEKGSNEQEKVLSAEKTKSLTVDGNVGKLVGIDSFQPSVQKQLKNVKWVRSYDFIMPNSSVHNNGKSFINSETIEDFQKKNNLYPHRTAFPSVALKGHSLASVFKNSVLRSLGAASNPFPYKAAVCFAESGRNLHSSSQQLLPFAASPATCSFSGEKGLLPVSENDLESTSKVNIPVKVVSSNRKQEDNQTEEHKAVSTVGQISSQHKSEYLHINITGEDRSQQPGDKPLELKNSERTNNTNDGPVISSVFSLSSGSENVPEGIKWNSSTSKIKSIELLRRKIAQLIESCGKPSSLASNSAHRRSVGQASKGTSKATSEGIQEINVSLTGLGHSTGTLQKPPNDGGITGNRQLTHQQIYPHFADGSNRKTKSRVARKAHVATPVLIPKGAVLRVLNSSENAHIIEATCEAPVSIPCSERQLIKPVPFCPVRQADSDLQPLRSERGPIDMSPNIETPLRPKLRKESAVCSTIHRKTGLLYGQQGSSELNKQGRLLSRSLSISRNKTKQVHLSRKKNKIQAEPSRCLKDPSIFQVARQLRLIAAKPDQLIKCPRRNQPVIVLNHPDVDSPEVTNVMKVINKYKGNVLKVVLSERTRCQLGIRRHHVRLTYQNAEEASQIKRQMMLKMKLKKVHKNNYQVVDSLPDDSSQCVFKCWFCGRLYEDQEEWMSHGQRHLIEATRDWDVLSSKGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	KDIGQQLYTTHLNGG CCHHHHEEECCCCCC	12.78	-
23	Phosphorylation	GHNSLTMSPKQPDAN CCCCCCCCCCCCCCC	24.58	-
42	Phosphorylation	PNRQEAQTLLYQGSE CCHHHHHHHHHCCCH	26.27	28842319
48	Phosphorylation	QTLLYQGSEAEAAMM HHHHHCCCHHHHHHH	20.36	28842319
64	Ubiquitination	IATCAKCKSVHKISL HHHHHHCCCCEEEEH	55.60	22817900
68	Ubiquitination	AKCKSVHKISLQDLQ HHCCCCEEEEHHHHH	31.66	21906983
76	Ubiquitination	ISLQDLQKGTGKDGM EEHHHHHCCCCCCCE	66.78	21890473
80	Ubiquitination	DLQKGTGKDGMYVCF HHHCCCCCCCEEEEE	51.45	22817900
124	Ubiquitination	FSSSVNSKFKVRNFK CCHHHCCCEEEECCC	43.96	29967540
151	Ubiquitination	TKDPLQYKKHTLQHE CCCCCCCCCCCCCHH	25.72	29967540
152	Ubiquitination	KDPLQYKKHTLQHEE CCCCCCCCCCCCHHH	36.57	29967540
207	Ubiquitination	IRNDYIVKHTKRVHE HCCCEEEEHHHHHHH	35.68	29967540
223	Methylation	AGAKRPVKAVAKLEP CCCCCCHHHHEECCC	39.56	116253727
237	Ubiquitination	PKRTGTSKQNPELLK CCCCCCCCCCHHHHH	54.66	29967540
244	Ubiquitination	KQNPELLKASNPRTT CCCHHHHHHCCCCCC	63.49	29967540
282	Methylation	IMLLPEPKEYQKDVV EEECCCCCCCCCCEE	68.35	23644510
286	Ubiquitination	PEPKEYQKDVVCIPN CCCCCCCCCEEEECC	52.14	29967540
294	Ubiquitination	DVVCIPNKMTLSEPN CEEEECCCCCCCCCC	28.10	29967540
317	Phosphorylation	NVEVEVLSPAKEPVQ CEEEEEECCCCCCCC	28.17	24719451
391	Phosphorylation	RMVKEKGSNEQEKVL HHHHCCCCCHHHHHH	48.54	30622161
396	Ubiquitination	KGSNEQEKVLSAEKT CCCCHHHHHHHHHHH	48.44	-
399	Phosphorylation	NEQEKVLSAEKTKSL CHHHHHHHHHHHCCE	37.05	26091039
403	Phosphorylation	KVLSAEKTKSLTVDG HHHHHHHHCCEEEEC	19.85	28258704
404	Ubiquitination	VLSAEKTKSLTVDGN HHHHHHHCCEEEECC	55.31	-
405	Phosphorylation	LSAEKTKSLTVDGNV HHHHHHCCEEEECCC	34.21	28258704
407	Phosphorylation	AEKTKSLTVDGNVGK HHHHCCEEEECCCCC	24.52	28258704
414	Ubiquitination	TVDGNVGKLVGIDSF EEECCCCCEEECCCC	35.40	29967540
427	Ubiquitination	SFQPSVQKQLKNVKW CCCHHHHHHHCCCCE	56.28	29967540
430	Ubiquitination	PSVQKQLKNVKWVRS HHHHHHHCCCCEEEE	58.14	-
433	Ubiquitination	QKQLKNVKWVRSYDF HHHHCCCCEEEECCE	49.73	-
437	Phosphorylation	KNVKWVRSYDFIMPN CCCCEEEECCEECCC	21.31	25278378
438	Phosphorylation	NVKWVRSYDFIMPNS CCCEEEECCEECCCC	12.33	25278378
445	Phosphorylation	YDFIMPNSSVHNNGK CCEECCCCCCCCCCC	28.06	25278378
446	Phosphorylation	DFIMPNSSVHNNGKS CEECCCCCCCCCCCC	33.75	25278378
452	Ubiquitination	SSVHNNGKSFINSET CCCCCCCCCCCCHHH	44.29	-
453	Phosphorylation	SVHNNGKSFINSETI CCCCCCCCCCCHHHH	32.53	25278378
457	Phosphorylation	NGKSFINSETIEDFQ CCCCCCCHHHHHHHH	31.16	25278378
459	Phosphorylation	KSFINSETIEDFQKK CCCCCHHHHHHHHHH	29.50	25278378
465	Ubiquitination	ETIEDFQKKNNLYPH HHHHHHHHHCCCCCC	58.42	21906983
466	Ubiquitination	TIEDFQKKNNLYPHR HHHHHHHHCCCCCCC	40.04	22817900
482	Sumoylation	AFPSVALKGHSLASV CCCHHHHCCCCHHHH	44.85	28112733
482	Ubiquitination	AFPSVALKGHSLASV CCCHHHHCCCCHHHH	44.85	29967540
488	Phosphorylation	LKGHSLASVFKNSVL HCCCCHHHHHHHHHH	33.12	-
491	Sumoylation	HSLASVFKNSVLRSL CCHHHHHHHHHHHHH	46.27	28112733
491	Ubiquitination	HSLASVFKNSVLRSL CCHHHHHHHHHHHHH	46.27	-
493	Phosphorylation	LASVFKNSVLRSLGA HHHHHHHHHHHHHCC	24.10	-
508	Ubiquitination	ASNPFPYKAAVCFAE CCCCCCCEEEEEEHH	30.06	22505724
549	Phosphorylation	EKGLLPVSENDLEST CCCEEECCHHHCCCC	28.83	24719451
555	Phosphorylation	VSENDLESTSKVNIP CCHHHCCCCCCCCCC	45.32	24719451
557	Phosphorylation	ENDLESTSKVNIPVK HHHCCCCCCCCCCEE	43.83	24719451
558	Ubiquitination	NDLESTSKVNIPVKV HHCCCCCCCCCCEEE	39.11	29967540
558	Sumoylation	NDLESTSKVNIPVKV HHCCCCCCCCCCEEE	39.11	28112733
564	Ubiquitination	SKVNIPVKVVSSNRK CCCCCCEEEEECCCC	31.40	21906983
584	Phosphorylation	TEEHKAVSTVGQISS CHHHHHHHHHHHHHH	23.41	26270265
585	Phosphorylation	EEHKAVSTVGQISSQ HHHHHHHHHHHHHHC	23.27	26270265
590	Phosphorylation	VSTVGQISSQHKSEY HHHHHHHHHCCCCCE	18.96	26270265
591	Phosphorylation	STVGQISSQHKSEYL HHHHHHHHCCCCCEE	37.62	26270265
594	Sumoylation	GQISSQHKSEYLHIN HHHHHCCCCCEEEEE	37.03	28112733
608	Phosphorylation	NITGEDRSQQPGDKP EEECCCCCCCCCCCC	45.55	-
614	Ubiquitination	RSQQPGDKPLELKNS CCCCCCCCCCCCCCC	58.37	29967540
619	Ubiquitination	GDKPLELKNSERTNN CCCCCCCCCCCCCCC	49.40	-
658	Ubiquitination	KWNSSTSKIKSIELL CCCCCCHHHHHHHHH	55.00	29967540
660	Ubiquitination	NSSTSKIKSIELLRR CCCCHHHHHHHHHHH	49.47	29967540
668	Ubiquitination	SIELLRRKIAQLIES HHHHHHHHHHHHHHH	35.64	29967540
678	Ubiquitination	QLIESCGKPSSLASN HHHHHCCCCHHHHCC	46.16	29967540
726	Ubiquitination	HSTGTLQKPPNDGGI CCCCCCCCCCCCCCC	66.60	29967540
763	Ubiquitination	TKSRVARKAHVATPV CHHHHHHHHCCCCCE	32.86	29967540
774	Ubiquitination	ATPVLIPKGAVLRVL CCCEEECCCCEEEEC	53.13	29967540
809	Ubiquitination	CSERQLIKPVPFCPV CCCCCCCCCCCCCCC	48.86	29967540
809	Sumoylation	CSERQLIKPVPFCPV CCCCCCCCCCCCCCC	48.86	28112733
836	Phosphorylation	ERGPIDMSPNIETPL CCCCCCCCCCCCCCC	15.85	27050516
841	Phosphorylation	DMSPNIETPLRPKLR CCCCCCCCCCCHHHH	24.67	24719451
846	Sumoylation	IETPLRPKLRKESAV CCCCCCHHHHHHHCC	55.26	28112733
860	Ubiquitination	VCSTIHRKTGLLYGQ CHHHHHHHHCCCCCC	32.55	29967540
860	Sumoylation	VCSTIHRKTGLLYGQ CHHHHHHHHCCCCCC	32.55	28112733
875	Ubiquitination	QGSSELNKQGRLLSR CCCHHHHHHHCHHHH	67.75	21906983
885	Phosphorylation	RLLSRSLSISRNKTK CHHHHHEECCCCCCC	21.55	24719451
897	Phosphorylation	KTKQVHLSRKKNKIQ CCCCEECCCCCCCCC	27.46	-
912	Ubiquitination	AEPSRCLKDPSIFQV CCHHHHCCCHHHHHH	71.82	29967540
929	Ubiquitination	QLRLIAAKPDQLIKC HHHHHHCCHHHEEEC	39.85	-
935	Ubiquitination	AKPDQLIKCPRRNQP CCHHHEEECCCCCCC	46.94	-
979	Phosphorylation	KVVLSERTRCQLGIR EEEEECCCCHHHCCC	31.57	-
1004	Ubiquitination	AEEASQIKRQMMLKM HHHHHHHHHHHHHHH	29.01	21906983
1010	Acetylation	IKRQMMLKMKLKKVH HHHHHHHHHHHHHHH	18.98	7845003
1012	Acetylation	RQMMLKMKLKKVHKN HHHHHHHHHHHHHHC	56.41	19819187
1018	Ubiquitination	MKLKKVHKNNYQVVD HHHHHHHHCCCEEEC	50.29	-
1072	Ubiquitination	DWDVLSSKGK----- CHHHHHCCCC-----	68.30	-
1074	Ubiquitination	DVLSSKGK------- HHHHCCCC-------	61.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of Z518B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of Z518B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of Z518B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of Z518B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.