| UniProt ID | TBC13_HUMAN | |
|---|---|---|
| UniProt AC | Q9NVG8 | |
| Protein Name | TBC1 domain family member 13 | |
| Gene Name | TBC1D13 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 400 | |
| Subcellular Localization | Membrane . Cytoplasm . | |
| Protein Description | Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.. | |
| Protein Sequence | MSSLHKSRIADFQDVLKEPSIALEKLRELSFSGIPCEGGLRCLCWKILLNYLPLERASWTSILAKQRELYAQFLREMIIQPGIAKANMGVSREDVTFEDHPLNPNPDSRWNTYFKDNEVLLQIDKDVRRLCPDISFFQRATDYPCLLILDPQNEFETLRKRVEQTTLKSQTVARNRSGVTNMSSPHKNSVPSSLNEYEVLPNGCEAHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVNMRLLQDYPITDVCQILQKAKELQDSK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Acetylation | --MSSLHKSRIADFQ --CCCCCHHHCCHHH | 46.88 | 25953088 | |
| 17 | Ubiquitination | ADFQDVLKEPSIALE CHHHHHHHCHHHHHH | 68.38 | - | |
| 25 | Ubiquitination | EPSIALEKLRELSFS CHHHHHHHHHHHCCC | 54.41 | - | |
| 58 | Phosphorylation | YLPLERASWTSILAK CCCCCHHCHHHHHHH | 36.79 | - | |
| 91 | Phosphorylation | AKANMGVSREDVTFE HHCCCCCCHHHCCCC | 24.99 | 28348404 | |
| 96 | Phosphorylation | GVSREDVTFEDHPLN CCCHHHCCCCCCCCC | 33.36 | 17924679 | |
| 106 | Ubiquitination | DHPLNPNPDSRWNTY CCCCCCCCCCCCCCC | 42.06 | - | |
| 108 | Phosphorylation | PLNPNPDSRWNTYFK CCCCCCCCCCCCCCC | 40.22 | 17924679 | |
| 112 | Phosphorylation | NPDSRWNTYFKDNEV CCCCCCCCCCCCCEE | 24.31 | - | |
| 113 | Phosphorylation | PDSRWNTYFKDNEVL CCCCCCCCCCCCEEE | 12.86 | - | |
| 115 | Ubiquitination | SRWNTYFKDNEVLLQ CCCCCCCCCCEEEEE | 49.59 | - | |
| 125 | Ubiquitination | EVLLQIDKDVRRLCP EEEEEECHHHHHHCC | 60.80 | - | |
| 131 | Glutathionylation | DKDVRRLCPDISFFQ CHHHHHHCCCCCHHH | 2.42 | 22555962 | |
| 135 | Phosphorylation | RRLCPDISFFQRATD HHHCCCCCHHHHHCC | 27.65 | 25159151 | |
| 143 | Phosphorylation | FFQRATDYPCLLILD HHHHHCCCCEEEEEC | 7.47 | - | |
| 145 | Glutathionylation | QRATDYPCLLILDPQ HHHCCCCEEEEECCC | 3.83 | 22555962 | |
| 165 | Phosphorylation | LRKRVEQTTLKSQTV HHHHHHHHHHHCHHH | 22.16 | 30622161 | |
| 166 | Phosphorylation | RKRVEQTTLKSQTVA HHHHHHHHHHCHHHH | 31.70 | 30622161 | |
| 168 | Ubiquitination | RVEQTTLKSQTVARN HHHHHHHHCHHHHCC | 38.12 | - | |
| 177 | Phosphorylation | QTVARNRSGVTNMSS HHHHCCCCCCCCCCC | 40.96 | 23401153 | |
| 180 | Phosphorylation | ARNRSGVTNMSSPHK HCCCCCCCCCCCCCC | 28.82 | 28176443 | |
| 183 | Phosphorylation | RSGVTNMSSPHKNSV CCCCCCCCCCCCCCC | 42.67 | 23401153 | |
| 184 | Phosphorylation | SGVTNMSSPHKNSVP CCCCCCCCCCCCCCC | 21.91 | 23401153 | |
| 189 | Phosphorylation | MSSPHKNSVPSSLNE CCCCCCCCCCCCCCE | 39.96 | 28857561 | |
| 192 | Phosphorylation | PHKNSVPSSLNEYEV CCCCCCCCCCCEEEE | 45.35 | 28796482 | |
| 193 | Phosphorylation | HKNSVPSSLNEYEVL CCCCCCCCCCEEEEC | 29.19 | 28796482 | |
| 197 | Phosphorylation | VPSSLNEYEVLPNGC CCCCCCEEEECCCCH | 15.40 | 28796482 | |
| 213 | Ubiquitination | AHWEVVERILFIYAK HHHHHHHHHHHHHHH | 21.21 | - | |
| 287 | Ubiquitination | SQCGITYKMEKVYST CCCCCEEEEEHHHHH | 31.75 | - | |
| 290 | Acetylation | GITYKMEKVYSTLKD CCEEEEEHHHHHHCC | 42.87 | 25953088 | |
| 298 | Ubiquitination | VYSTLKDKDVELYLK HHHHHCCCCHHHHHH | 63.18 | - | |
| 387 | Glutathionylation | DYPITDVCQILQKAK CCCHHHHHHHHHHHH | 2.01 | 22555962 | |
| 394 | Ubiquitination | CQILQKAKELQDSK- HHHHHHHHHHHCCC- | 67.02 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBC13_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBC13_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBC13_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| WDR12_HUMAN | WDR12 | physical | 22939629 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-96 AND SER-108, AND MASSSPECTROMETRY. | |
