PRRC1_HUMAN - dbPTM
PRRC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRRC1_HUMAN
UniProt AC Q96M27
Protein Name Protein PRRC1
Gene Name PRRC1
Organism Homo sapiens (Human).
Sequence Length 445
Subcellular Localization Golgi apparatus .
Protein Description
Protein Sequence MMEESGIETTPPGTPPPNPAGLAATAMSSTPVPLAATSSFSSPNVSSMESFPPLAYSTPQPPLPPVRPSAPLPFVPPPAVPSVPPLVTSMPPPVSPSTAAAFGNPPVSHFPPSTSAPNTLLPAPPSGPPISGFSVGSTYDITRGHAGRAPQTPLMPSFSAPSGTGLLPTPITQQASLTSLAQGTGTTSAITFPEEQEDPRITRGQDEASAGGIWGFIKGVAGNPMVKSVLDKTKHSVESMITTLDPGMAPYIKSGGELDIVVTSNKEVKVAAVRDAFQEVFGLAVVVGEAGQSNIAPQPVGYAAGLKGAQERIDSLRRTGVIHEKQTAVSVENFIAELLPDKWFDIGCLVVEDPVHGIHLETFTQATPVPLEFVQQAQSLTPQDYNLRWSGLLVTVGEVLEKSLLNVSRTDWHMAFTGMSRRQMIYSAARAIAGMYKQRLPPRTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationMEESGIETTPPGTPP
CCCCCCCCCCCCCCC		42.5626074081
10PhosphorylationEESGIETTPPGTPPP
CCCCCCCCCCCCCCC		18.0726074081
14PhosphorylationIETTPPGTPPPNPAG
CCCCCCCCCCCCCCC		38.0926074081
37O-linked_GlycosylationTPVPLAATSSFSSPN
CCCCEEECCCCCCCC		21.2122661428
38O-linked_GlycosylationPVPLAATSSFSSPNV
CCCEEECCCCCCCCC		25.3422661428
67DimethylationQPPLPPVRPSAPLPF
CCCCCCCCCCCCCCC		25.81-
67MethylationQPPLPPVRPSAPLPF
CCCCCCCCCCCCCCC		25.8152719577
82PhosphorylationVPPPAVPSVPPLVTS
CCCCCCCCCCCCCCC		40.4326074081
88O-linked_GlycosylationPSVPPLVTSMPPPVS
CCCCCCCCCCCCCCC		27.3022661428
88PhosphorylationPSVPPLVTSMPPPVS
CCCCCCCCCCCCCCC		27.3026074081
89PhosphorylationSVPPLVTSMPPPVSP
CCCCCCCCCCCCCCH		23.0826074081
89O-linked_GlycosylationSVPPLVTSMPPPVSP
CCCCCCCCCCCCCCH		23.0822661428
95PhosphorylationTSMPPPVSPSTAAAF
CCCCCCCCHHHHHHH		20.9326074081
97PhosphorylationMPPPVSPSTAAAFGN
CCCCCCHHHHHHHCC		24.1526074081
98PhosphorylationPPPVSPSTAAAFGNP
CCCCCHHHHHHHCCC		24.5726074081
98O-linked_GlycosylationPPPVSPSTAAAFGNP
CCCCCHHHHHHHCCC		24.5722661428
108O-linked_GlycosylationAFGNPPVSHFPPSTS
HHCCCCCCCCCCCCC		25.7822661428
113O-linked_GlycosylationPVSHFPPSTSAPNTL
CCCCCCCCCCCCCCC		34.9222661428
114O-linked_GlycosylationVSHFPPSTSAPNTLL
CCCCCCCCCCCCCCC		34.3822661428
115O-linked_GlycosylationSHFPPSTSAPNTLLP
CCCCCCCCCCCCCCC		46.1722661428
119O-linked_GlycosylationPSTSAPNTLLPAPPS
CCCCCCCCCCCCCCC		28.7222661428
126O-linked_GlycosylationTLLPAPPSGPPISGF
CCCCCCCCCCCCCCE		63.9722661428
131O-linked_GlycosylationPPSGPPISGFSVGST
CCCCCCCCCEECCCE		39.2922661428
139PhosphorylationGFSVGSTYDITRGHA
CEECCCEEECCCCCC		13.6720736484
152PhosphorylationHAGRAPQTPLMPSFS
CCCCCCCCCCCCCCC		19.8227251275
152O-linked_GlycosylationHAGRAPQTPLMPSFS
CCCCCCCCCCCCCCC		19.8222661428
157PhosphorylationPQTPLMPSFSAPSGT
CCCCCCCCCCCCCCC		20.1927251275
157O-linked_GlycosylationPQTPLMPSFSAPSGT
CCCCCCCCCCCCCCC		20.1922661428
159O-linked_GlycosylationTPLMPSFSAPSGTGL
CCCCCCCCCCCCCCC		43.5422661428
159PhosphorylationTPLMPSFSAPSGTGL
CCCCCCCCCCCCCCC		43.5427251275
164O-linked_GlycosylationSFSAPSGTGLLPTPI
CCCCCCCCCCCCCCC		29.0622661428
169O-linked_GlycosylationSGTGLLPTPITQQAS
CCCCCCCCCCCCCHH		27.5622661428
169PhosphorylationSGTGLLPTPITQQAS
CCCCCCCCCCCCCHH		27.5627251275
172O-linked_GlycosylationGLLPTPITQQASLTS
CCCCCCCCCCHHHHH		18.8122661428
172PhosphorylationGLLPTPITQQASLTS
CCCCCCCCCCHHHHH		18.8127251275
176O-linked_GlycosylationTPITQQASLTSLAQG
CCCCCCHHHHHHHCC		28.0422661428
176PhosphorylationTPITQQASLTSLAQG
CCCCCCHHHHHHHCC		28.0428348404
178PhosphorylationITQQASLTSLAQGTG
CCCCHHHHHHHCCCC		21.1428348404
178O-linked_GlycosylationITQQASLTSLAQGTG
CCCCHHHHHHHCCCC		21.1422661428
179PhosphorylationTQQASLTSLAQGTGT
CCCHHHHHHHCCCCC		27.3128348404
179O-linked_GlycosylationTQQASLTSLAQGTGT
CCCHHHHHHHCCCCC		27.3122661428
184PhosphorylationLTSLAQGTGTTSAIT
HHHHHCCCCCCCEEE		21.1929496963
184O-linked_GlycosylationLTSLAQGTGTTSAIT
HHHHHCCCCCCCEEE		21.1922661428
186PhosphorylationSLAQGTGTTSAITFP
HHHCCCCCCCEEECC		19.8828348404
186O-linked_GlycosylationSLAQGTGTTSAITFP
HHHCCCCCCCEEECC		19.8822661428
187O-linked_GlycosylationLAQGTGTTSAITFPE
HHCCCCCCCEEECCH		19.9422661428
187PhosphorylationLAQGTGTTSAITFPE
HHCCCCCCCEEECCH		19.9428348404
188O-linked_GlycosylationAQGTGTTSAITFPEE
HCCCCCCCEEECCHH		19.9422661428
188PhosphorylationAQGTGTTSAITFPEE
HCCCCCCCEEECCHH		19.9428348404
209PhosphorylationTRGQDEASAGGIWGF
CCCCCHHHHCCHHHH		25.9628857561
218UbiquitinationGGIWGFIKGVAGNPM
CCHHHHHHHHCCCHH		45.10-
225SulfoxidationKGVAGNPMVKSVLDK
HHHCCCHHHHHHHHH		7.4130846556
227AcetylationVAGNPMVKSVLDKTK
HCCCHHHHHHHHHCC		28.7025953088
227UbiquitinationVAGNPMVKSVLDKTK
HCCCHHHHHHHHHCC		28.7029967540
233PhosphorylationVKSVLDKTKHSVESM
HHHHHHHCCCCHHHH		33.3921712546
236PhosphorylationVLDKTKHSVESMITT
HHHHCCCCHHHHHHH		29.1825159151
236 (in isoform 2)Phosphorylation-29.1821406692
239PhosphorylationKTKHSVESMITTLDP
HCCCCHHHHHHHCCC		17.2121406692
242PhosphorylationHSVESMITTLDPGMA
CCHHHHHHHCCCCCC		16.8021406692
243PhosphorylationSVESMITTLDPGMAP
CHHHHHHHCCCCCCC		20.4521406692
243 (in isoform 2)Phosphorylation-20.4521406692
251PhosphorylationLDPGMAPYIKSGGEL
CCCCCCCEECCCCEE		16.0821406692
251 (in isoform 2)Phosphorylation-16.0827642862
254O-linked_GlycosylationGMAPYIKSGGELDIV
CCCCEECCCCEEEEE		42.3322661428
254PhosphorylationGMAPYIKSGGELDIV
CCCCEECCCCEEEEE		42.3325159151
263PhosphorylationGELDIVVTSNKEVKV
CEEEEEEECCCCEEE		18.7127251275
264PhosphorylationELDIVVTSNKEVKVA
EEEEEEECCCCEEEH		34.0027251275
269AcetylationVTSNKEVKVAAVRDA
EECCCCEEEHHHHHH		27.5225953088
307MethylationVGYAAGLKGAQERID
CCHHHCCCHHHHHHH		51.81115975787
325UbiquitinationRTGVIHEKQTAVSVE
HHCCCCCCCCEEEHH		38.4932015554
390PhosphorylationQDYNLRWSGLLVTVG
CCCCCCHHHEEEEHH		17.0921406692
390 (in isoform 2)Phosphorylation-17.0921406692
395PhosphorylationRWSGLLVTVGEVLEK
CHHHEEEEHHHHHHH		23.8221406692
403PhosphorylationVGEVLEKSLLNVSRT
HHHHHHHHHHCCCCC		28.8123911959
408PhosphorylationEKSLLNVSRTDWHMA
HHHHHCCCCCCHHHH		28.5222617229
436PhosphorylationARAIAGMYKQRLPPR
HHHHHHHHHHCCCCC		11.75-
437UbiquitinationRAIAGMYKQRLPPRT
HHHHHHHHHCCCCCC		21.7624816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRRC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRRC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRRC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
MCM2_HUMANMCM2physical
22863883
MCM7_HUMANMCM7physical
22863883
ROA1_HUMANHNRNPA1physical
26344197
PEPL1_HUMANNPEPL1physical
26344197
PA1B2_HUMANPAFAH1B2physical
26344197
PPIB_HUMANPPIBphysical
26344197
PSMG1_HUMANPSMG1physical
26344197
RAB1A_HUMANRAB1Aphysical
26344197
GLYC_HUMANSHMT1physical
26344197
GLYM_HUMANSHMT2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRRC1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, AND MASSSPECTROMETRY.

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