dbPTM

SLK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SLK_HUMAN
UniProt AC	Q9H2G2
Protein Name	STE20-like serine/threonine-protein kinase
Gene Name	SLK
Organism	Homo sapiens (Human).
Sequence Length	1235
Subcellular Localization	Cytoplasm.
Protein Description	Mediates apoptosis and actin stress fiber dissolution..
Protein Sequence	MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFFNFRKI ------CCCCCHHHH	50.26	29514088
8	Acetylation	MSFFNFRKIFKLGSE CCCCCHHHHHCCCCH	48.64	26051181
11	Ubiquitination	FNFRKIFKLGSEKKK CCHHHHHCCCCHHHH	56.25	29967540
14	Phosphorylation	RKIFKLGSEKKKKQY HHHHCCCCHHHHHHH	57.59	28355574
21	Phosphorylation	SEKKKKQYEHVKRDL CHHHHHHHHHHHCCC	19.51	-
50	Ubiquitination	GAFGKVYKAQNKETS CHHHHEEECCCCCCH	46.62	29967540
54	Ubiquitination	KVYKAQNKETSVLAA HEEECCCCCCHHHEE	50.73	30230243
56	Phosphorylation	YKAQNKETSVLAAAK EECCCCCCHHHEEEE	26.24	21949786
57	Phosphorylation	KAQNKETSVLAAAKV ECCCCCCHHHEEEEE	19.07	21949786
63	Ubiquitination	TSVLAAAKVIDTKSE CHHHEEEEEECCCCH	34.69	29967540
139	Phosphorylation	IQVVCKQTLDALNYL HHHHHHHHHHHHHHH	16.46	20068231
145	Phosphorylation	QTLDALNYLHDNKII HHHHHHHHHHCCCEE	13.28	20068231
150	Ubiquitination	LNYLHDNKIIHRDLK HHHHHCCCEECCCCC	49.44	29967540
157	Ubiquitination	KIIHRDLKAGNILFT CEECCCCCCCCEEEE	59.54	30230243
177	Phosphorylation	KLADFGVSAKNTRTI EEHHHCCCCCCCCEE	33.63	27067055
179	Acetylation	ADFGVSAKNTRTIQR HHHCCCCCCCCEECC	51.88	25953088
179	Ubiquitination	ADFGVSAKNTRTIQR HHHCCCCCCCCEECC	51.88	32142685
181	Phosphorylation	FGVSAKNTRTIQRRD HCCCCCCCCEECCCC	28.60	25159151
183	Phosphorylation	VSAKNTRTIQRRDSF CCCCCCCEECCCCCC	21.30	27273156
189	Phosphorylation	RTIQRRDSFIGTPYW CEECCCCCCCCCCCC	19.56	25159151
193	Phosphorylation	RRDSFIGTPYWMAPE CCCCCCCCCCCCCCE	14.37	23927012
195	Phosphorylation	DSFIGTPYWMAPEVV CCCCCCCCCCCCEEE	13.98	23927012
206	Phosphorylation	PEVVMCETSKDRPYD CEEEEEECCCCCCCC	35.83	23927012
207	Phosphorylation	EVVMCETSKDRPYDY EEEEEECCCCCCCCC	15.40	23927012
212	Phosphorylation	ETSKDRPYDYKADVW ECCCCCCCCCCHHHH	32.57	-
214	Phosphorylation	SKDRPYDYKADVWSL CCCCCCCCCHHHHHH	11.39	-
246	Malonylation	NPMRVLLKIAKSEPP CHHHHHHHHHCCCCC	36.14	26320211
249	Ubiquitination	RVLLKIAKSEPPTLA HHHHHHHCCCCCCCC	59.84	33845483
250	Phosphorylation	VLLKIAKSEPPTLAQ HHHHHHCCCCCCCCC	46.44	23312004
254	Phosphorylation	IAKSEPPTLAQPSRW HHCCCCCCCCCCCCC	45.50	25002506
259	Phosphorylation	PPTLAQPSRWSSNFK CCCCCCCCCCCHHHH	34.01	25002506
266	Ubiquitination	SRWSSNFKDFLKKCL CCCCHHHHHHHHHHH	52.39	29967540
298	Ubiquitination	FVTVDSNKPIRELIA EEECCCCCCHHHHHH	45.86	29967540
312	Phosphorylation	AEAKAEVTEEVEDGK HHHHHHHHHHCCCCC	20.24	29978859
319	Ubiquitination	TEEVEDGKEEDEEEE HHHCCCCCCCCCHHH	70.97	22817900
319 (in isoform 1)	Ubiquitination	-	70.97	21906983
319 (in isoform 2)	Ubiquitination	-	70.97	21906983
327	Phosphorylation	EEDEEEETENSLPIP CCCCHHHCCCCCCCC	43.69	26657352
330	Phosphorylation	EEEETENSLPIPASK CHHHCCCCCCCCHHH	29.32	30278072
336	Phosphorylation	NSLPIPASKRASSDL CCCCCCHHHHCCCCC	19.81	25849741
337	Acetylation	SLPIPASKRASSDLS CCCCCHHHHCCCCCC	54.83	26051181
337	Ubiquitination	SLPIPASKRASSDLS CCCCCHHHHCCCCCC	54.83	21906983
337 (in isoform 1)	Ubiquitination	-	54.83	21906983
337 (in isoform 2)	Ubiquitination	-	54.83	21906983
340	Phosphorylation	IPASKRASSDLSIAS CCHHHHCCCCCCCCC	28.55	29255136
341	Phosphorylation	PASKRASSDLSIASS CHHHHCCCCCCCCCC	41.40	29255136
344	Phosphorylation	KRASSDLSIASSEED HHCCCCCCCCCCCCH	22.54	29255136
347	Phosphorylation	SSDLSIASSEEDKLS CCCCCCCCCCCHHHH	36.29	25159151
348	Phosphorylation	SDLSIASSEEDKLSQ CCCCCCCCCCHHHHC	35.66	25159151
354	Phosphorylation	SSEEDKLSQNACILE CCCCHHHHCCCHHHH	27.42	17525332
362	Phosphorylation	QNACILESVSEKTER CCCHHHHHHCHHHHC	27.74	20873877
364	Phosphorylation	ACILESVSEKTERSN CHHHHHHCHHHHCCC	42.53	28060719
366	Ubiquitination	ILESVSEKTERSNSE HHHHHCHHHHCCCCH	48.45	32015554
367	Phosphorylation	LESVSEKTERSNSED HHHHCHHHHCCCCHH	32.36	23403867
370	Phosphorylation	VSEKTERSNSEDKLN HCHHHHCCCCHHHHH	38.18	23927012
372	Phosphorylation	EKTERSNSEDKLNSK HHHHCCCCHHHHHHH	48.71	30278072
378	Phosphorylation	NSEDKLNSKILNEKP CCHHHHHHHHHCCCC	31.35	23927012
379	Ubiquitination	SEDKLNSKILNEKPT CHHHHHHHHHCCCCC	50.57	22817900
384	Ubiquitination	NSKILNEKPTTDEPE HHHHHCCCCCCCCHH	46.74	21906983
384 (in isoform 1)	Ubiquitination	-	46.74	21906983
384 (in isoform 2)	Ubiquitination	-	46.74	21906983
387	Ubiquitination	ILNEKPTTDEPEKAV HHCCCCCCCCHHHHH	47.06	24816145
399	Ubiquitination	KAVEDINEHITDAQL HHHHHHHHHCCHHHH	36.68	24816145
415	Methylation	AMTELHDRTAVIKEN HHHHHHHHCHHHCCC	17.52	115917133
416	Phosphorylation	MTELHDRTAVIKENE HHHHHHHCHHHCCCH	31.19	28555341
419	Ubiquitination	LHDRTAVIKENEREK HHHHCHHHCCCHHHC	4.26	24816145
420	Ubiquitination	HDRTAVIKENEREKR HHHCHHHCCCHHHCC	48.14	24816145
436	Phosphorylation	KLENLPDTEDQETVD CCCCCCCCCCCCCEE	39.25	29523821
441	Phosphorylation	PDTEDQETVDINSVS CCCCCCCCEECCCCC	20.18	29523821
446	Phosphorylation	QETVDINSVSEGKEN CCCEECCCCCCCCCC	27.62	26657352
448	Phosphorylation	TVDINSVSEGKENNI CEECCCCCCCCCCCE	40.21	25159151
465	Ubiquitination	TLETNIEHNLKSEEE EEEHHHHHHCCCHHH	40.92	24816145
487	Sumoylation	MFENKLIKSEEIKDT HHHHHCCCHHHHHHH	63.35	-
487	Ubiquitination	MFENKLIKSEEIKDT HHHHHCCCHHHHHHH	63.35	33845483
488	Phosphorylation	FENKLIKSEEIKDTI HHHHCCCHHHHHHHH	33.21	29514088
492	Ubiquitination	LIKSEEIKDTILQTV CCCHHHHHHHHHHHH	52.69	21906983
492 (in isoform 1)	Ubiquitination	-	52.69	21906983
492 (in isoform 2)	Ubiquitination	-	52.69	21906983
494	Phosphorylation	KSEEIKDTILQTVDL CHHHHHHHHHHHHHH	20.70	-
503	Phosphorylation	LQTVDLVSQETGEKE HHHHHHHHCCCCCCC	29.60	29514088
506	Phosphorylation	VDLVSQETGEKEANI HHHHHCCCCCCCCCC	42.90	29514088
518	Phosphorylation	ANIQAVDSEVGLTKE CCCEEECCCCCCCHH	27.81	26657352
523	Phosphorylation	VDSEVGLTKEDTQEK ECCCCCCCHHHHHHH	26.85	18691976
524	Ubiquitination	DSEVGLTKEDTQEKL CCCCCCCHHHHHHHH	59.65	21906983
524 (in isoform 1)	Ubiquitination	-	59.65	21906983
524 (in isoform 2)	Ubiquitination	-	59.65	21906983
527	Phosphorylation	VGLTKEDTQEKLGED CCCCHHHHHHHHCCC	39.45	20068231
530	Ubiquitination	TKEDTQEKLGEDDKT CHHHHHHHHCCCCCH	52.56	33845483
537	Phosphorylation	KLGEDDKTQKDVISN HHCCCCCHHHHHHHC	48.09	20068231
543	Phosphorylation	KTQKDVISNTSDVIG CHHHHHHHCHHHHHC	33.62	18691976
545	Phosphorylation	QKDVISNTSDVIGTC HHHHHHCHHHHHCCC	21.36	20873877
546	Phosphorylation	KDVISNTSDVIGTCE HHHHHCHHHHHCCCH	33.84	23927012
551	Phosphorylation	NTSDVIGTCEAADVA CHHHHHCCCHHHHHH	8.96	26657352
565	Phosphorylation	AQKVDEDSAEDTQSN HHHCCCCCCHHHCCC	31.35	29255136
569	Phosphorylation	DEDSAEDTQSNDGKE CCCCCHHHCCCCCCC	25.96	22167270
571	Phosphorylation	DSAEDTQSNDGKEVV CCCHHHCCCCCCCHH	38.69	29255136
583	Ubiquitination	EVVEVGQKLINKPMV CHHHHHHHHHCCCCC	45.46	29967540
587	Ubiquitination	VGQKLINKPMVGPEA HHHHHHCCCCCCCCC	27.74	29967540
597	Phosphorylation	VGPEAGGTKEVPIKE CCCCCCCCCEEEHHH	24.10	23663014
608	Sulfoxidation	PIKEIVEMNEIEEGK EHHHHHHHHHHHCCC	3.65	30846556
623	Phosphorylation	NKEQAINSSENIMDI CHHHHCCCCCCCCCC	32.68	18691976
636	Phosphorylation	DINEEPGTTEGEEIT CCCCCCCCCCCCCCC	32.18	18691976
637	Phosphorylation	INEEPGTTEGEEITE CCCCCCCCCCCCCCC	48.16	18691976
643	Phosphorylation	TTEGEEITESSSTEE CCCCCCCCCCCCCCE	32.85	29449344
645	Phosphorylation	EGEEITESSSTEEME CCCCCCCCCCCCEEE	22.42	18691976
646	Phosphorylation	GEEITESSSTEEMEV CCCCCCCCCCCEEEE	34.74	17192257
647	Phosphorylation	EEITESSSTEEMEVR CCCCCCCCCCEEEEE	49.47	17192257
648	Phosphorylation	EITESSSTEEMEVRS CCCCCCCCCEEEEEE	37.60	29802988
655	Phosphorylation	TEEMEVRSVVADTDQ CCEEEEEEEEECCCH	26.56	25159151
660	Phosphorylation	VRSVVADTDQKALGS EEEEEECCCHHHHCC	30.50	29396449
663	Ubiquitination	VVADTDQKALGSEVQ EEECCCHHHHCCHHH	48.68	21906983
663 (in isoform 1)	Ubiquitination	-	48.68	21906983
663 (in isoform 2)	Ubiquitination	-	48.68	21906983
667	Phosphorylation	TDQKALGSEVQDASK CCHHHHCCHHHHHHH	35.13	20873877
673	Phosphorylation	GSEVQDASKVTTQID CCHHHHHHHCCCHHH	35.63	25627689
674	2-Hydroxyisobutyrylation	SEVQDASKVTTQIDK CHHHHHHHCCCHHHH	45.37	-
676	Phosphorylation	VQDASKVTTQIDKEK HHHHHHCCCHHHHHH	19.40	20068231
677	Phosphorylation	QDASKVTTQIDKEKK HHHHHCCCHHHHHHC	26.89	25159151
691	Acetylation	KEIPVSIKKEPEVTV CCCCCCCCCCCCEEE	43.51	25953088
700	Phosphorylation	EPEVTVVSQPTEPQP CCCEEEECCCCCCCC	26.55	28102081
703	Phosphorylation	VTVVSQPTEPQPVLI EEEECCCCCCCCEEE	53.30	28102081
712	Phosphorylation	PQPVLIPSININSDS CCCEEEEEEECCCCC	22.67	28102081
717	Phosphorylation	IPSININSDSGENKE EEEEECCCCCCCCHH	29.38	18691976
719	Phosphorylation	SININSDSGENKEEI EEECCCCCCCCHHHH	48.07	28102081
728	Phosphorylation	ENKEEIGSLSKTETI CCHHHHCCCCCCEEC	34.82	21815630
730	Phosphorylation	KEEIGSLSKTETILP HHHHCCCCCCEECCC	38.95	21815630
732	Phosphorylation	EIGSLSKTETILPPE HHCCCCCCEECCCCC	34.68	29514088
734	Phosphorylation	GSLSKTETILPPESE CCCCCCEECCCCCCC	32.80	29514088
735	Ubiquitination	SLSKTETILPPESEN CCCCCEECCCCCCCC	4.41	24816145
750	Phosphorylation	PKENDNDSGTGSTAD CCCCCCCCCCCCCCC	44.50	18691976
752	Phosphorylation	ENDNDSGTGSTADTS CCCCCCCCCCCCCCH	31.73	18691976
754	Phosphorylation	DNDSGTGSTADTSSI CCCCCCCCCCCCHHE	21.91	18691976
755	Phosphorylation	NDSGTGSTADTSSID CCCCCCCCCCCHHEE	29.87	18691976
759	Phosphorylation	TGSTADTSSIDLNLS CCCCCCCHHEEEEEE	26.33	18691976
772	Phosphorylation	LSISSFLSKTKDSGS EEHHHHHHCCCCCCC	35.95	22817900
773	Ubiquitination	SISSFLSKTKDSGSI EHHHHHHCCCCCCCC	62.84	22817900
774	Phosphorylation	ISSFLSKTKDSGSIS HHHHHHCCCCCCCCC	36.39	23927012
775	Methylation	SSFLSKTKDSGSISL HHHHHCCCCCCCCCH	54.34	42370353
775	Ubiquitination	SSFLSKTKDSGSISL HHHHHCCCCCCCCCH	54.34	22817900
775 (in isoform 1)	Ubiquitination	-	54.34	21906983
775 (in isoform 2)	Ubiquitination	-	54.34	21906983
777	Phosphorylation	FLSKTKDSGSISLQE HHHCCCCCCCCCHHH	35.68	22167270
779	Phosphorylation	SKTKDSGSISLQETR HCCCCCCCCCHHHHH	16.98	19664994
781	Phosphorylation	TKDSGSISLQETRRQ CCCCCCCCHHHHHHH	26.20	22167270
785	Phosphorylation	GSISLQETRRQKKTL CCCCHHHHHHHHHHH	20.42	23927012
789	Ubiquitination	LQETRRQKKTLKKTR HHHHHHHHHHHHHHH	46.01	24816145
795	Phosphorylation	QKKTLKKTRKFIVDG HHHHHHHHHCEEECC	37.19	21406692
806	Phosphorylation	IVDGVEVSVTTSKIV EECCEEEEEEECEEE	10.55	21406692
808	Phosphorylation	DGVEVSVTTSKIVTD CCEEEEEEECEEEEC	20.18	21406692
809	Phosphorylation	GVEVSVTTSKIVTDS CEEEEEEECEEEECC	26.35	21406692
810	Phosphorylation	VEVSVTTSKIVTDSD EEEEEEECEEEECCC	15.83	21406692
814	Phosphorylation	VTTSKIVTDSDSKTE EEECEEEECCCCCHH	33.00	29255136
816	Phosphorylation	TSKIVTDSDSKTEEL ECEEEECCCCCHHHH	34.12	29255136
818	Phosphorylation	KIVTDSDSKTEELRF EEEECCCCCHHHHHH	45.49	29255136
819	2-Hydroxyisobutyrylation	IVTDSDSKTEELRFL EEECCCCCHHHHHHH	66.02	-
820	Phosphorylation	VTDSDSKTEELRFLR EECCCCCHHHHHHHH	38.35	29255136
839	Ubiquitination	RELRFLQKEEQRAQQ HHHHHHHHHHHHHHH	66.42	24816145
850	Phosphorylation	RAQQQLNSKLQQQRE HHHHHHHHHHHHHHH	43.25	20860994
851	Ubiquitination	AQQQLNSKLQQQREQ HHHHHHHHHHHHHHH	49.60	32015554
871	Ubiquitination	EQEMMSKKRQYDQEI HHHHHHHHHHHHHHH	37.11	24816145
917	Ubiquitination	EQEKELSKFQNMLKN HHHHHHHHHHHHHHH	64.69	24816145
993	Ubiquitination	LANIERECLNNKQQL HHHHHHHHHCCHHHH	6.54	29967540
1019	2-Hydroxyisobutyrylation	EERHLQEKHQLLKQQ HHHHHHHHHHHHHHH	24.56	-
1024	Ubiquitination	QEKHQLLKQQLKDQY HHHHHHHHHHHHHHH	44.59	29967540
1046	Phosphorylation	LKRHEKETEQMQRYN HHHHHHHHHHHHHHH	42.45	28102081
1052	Phosphorylation	ETEQMQRYNQRLIEE HHHHHHHHHHHHHHH	9.96	22817900
1075	Ubiquitination	RARLPKIQRSEAKTR HHCCCHHHHHHHHHH	49.31	33845483
1089	Phosphorylation	RMAMFKKSLRINSTA HHHHHHHHHHCCCCC	24.38	29514088
1094	Phosphorylation	KKSLRINSTATPDQD HHHHHCCCCCCCCCC	19.63	25159151
1095	Phosphorylation	KSLRINSTATPDQDR HHHHCCCCCCCCCCH	30.02	28450419
1097	Phosphorylation	LRINSTATPDQDRDK HHCCCCCCCCCCHHH	27.73	25159151
1106	Ubiquitination	DQDRDKIKQFAAQEE CCCHHHHHHHHHHHH	45.14	33845483
1114	Ubiquitination	QFAAQEEKRQKNERM HHHHHHHHHHHHHHH	60.42	-
1152	2-Hydroxyisobutyrylation	LHQLQNEKCHLLVEH HHHHHHHCCCCHHHH	34.21	-
1155	Ubiquitination	LQNEKCHLLVEHETQ HHHHCCCCHHHHHHH	8.86	29967540
1156	Ubiquitination	QNEKCHLLVEHETQK HHHCCCCHHHHHHHH	1.57	24816145
1165	Acetylation	EHETQKLKELDEEHS HHHHHHHHHHCHHHH	64.37	26051181
1165	Ubiquitination	EHETQKLKELDEEHS HHHHHHHHHHCHHHH	64.37	29967540
1174	Ubiquitination	LDEEHSQELKEWREK HCHHHHHHHHHHHHH	65.90	32015554
1186	Ubiquitination	REKLRPRKKTLEEEF HHHHCCCHHHHHHHH	53.44	29967540
1187	Ubiquitination	EKLRPRKKTLEEEFA HHHCCCHHHHHHHHH	60.67	24816145
1188	Phosphorylation	KLRPRKKTLEEEFAR HHCCCHHHHHHHHHH	42.30	27251275
1196	Ubiquitination	LEEEFARKLQEQEVF HHHHHHHHHHHCCHH	51.60	29967540
1205	Methylation	QEQEVFFKMTGESEC HHCCHHHHHCCCCCC	24.88	115980963
1205	Ubiquitination	QEQEVFFKMTGESEC HHCCHHHHHCCCCCC	24.88	32015554
1206	Sulfoxidation	EQEVFFKMTGESECL HCCHHHHHCCCCCCC	5.00	21406390
1210	Phosphorylation	FFKMTGESECLNPST HHHHCCCCCCCCHHH	34.65	20860994
1217	Phosphorylation	SECLNPSTQSRISKF CCCCCHHHCCCHHHC	31.64	20860994
1219	Phosphorylation	CLNPSTQSRISKFYP CCCHHHCCCHHHCCC	31.50	-
1225	Phosphorylation	QSRISKFYPIPSLHS CCCHHHCCCCCCCCC	12.18	21945579
1229	Phosphorylation	SKFYPIPSLHSTGS- HHCCCCCCCCCCCC-	39.16	21945579
1232	Phosphorylation	YPIPSLHSTGS---- CCCCCCCCCCC----	39.49	21945579
1233	Phosphorylation	PIPSLHSTGS----- CCCCCCCCCC-----	30.60	21945579
1235	Phosphorylation	PSLHSTGS------- CCCCCCCC-------	36.82	21945579

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
183	T	Phosphorylation	Kinase	SLK	Q9H2G2	PSP
189	S	Phosphorylation	Kinase	PKACA	P17612	PSP
189	S	Phosphorylation	Kinase	SLK	Q9H2G2	PSP
347	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
348	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SLK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SLK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HGS_HUMAN	HGS	physical	22863883
ARHG1_HUMAN	ARHGEF1	physical	26344197
NSF1C_HUMAN	NSFL1C	physical	26344197
IPP2_HUMAN	PPP1R2	physical	26344197
RBM8A_HUMAN	RBM8A	physical	26344197
1433S_HUMAN	SFN	physical	26344197
1433B_HUMAN	YWHAB	physical	26344197
1433Z_HUMAN	YWHAZ	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SLK_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-779, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-181; SER-189; SER-340;SER-341; SER-344; SER-347; SER-348; SER-370; SER-565; THR-569;SER-571; SER-728; SER-777; SER-779; THR-814; SER-818 AND SER-1229, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-347; SER-348;SER-571; SER-777; SER-779 AND SER-818, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-330; SER-347;SER-348; SER-370; SER-546; THR-569; SER-571; SER-655; SER-777;SER-779; SER-818; THR-1097 AND SER-1235, AND MASS SPECTROMETRY.	18691976 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347; SER-348 ANDSER-354, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-755 AND SER-772, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-340; SER-341;SER-344; SER-347 AND SER-348, AND MASS SPECTROMETRY.	17081983 [Abstract]