SNR40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNR40_HUMAN
• UniProt AC: Q96DI7
• Protein Name: U5 small nuclear ribonucleoprotein 40 kDa protein
• Gene Name: SNRNP40
• Organism: Homo sapiens (Human).
• Sequence Length: 357
• Subcellular Localization: Nucleus .
• Protein Description: Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs..
• Protein Sequence: MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MIEQQKRKGPELP --CCHHHHCCCCCCC	56.63	115978631
8	Malonylation	MIEQQKRKGPELPLV CCHHHHCCCCCCCCC	82.77	26320211
18	Acetylation	ELPLVPVKRQRHELL CCCCCCCCCCCCEEE	36.42	-
18	Methylation	ELPLVPVKRQRHELL CCCCCCCCCCCCEEE	36.42	90805
18	Acetylation	ELPLVPVKRQRHELL CCCCCCCCCCCCEEE	36.42	23954790
18	Ubiquitination	ELPLVPVKRQRHELL CCCCCCCCCCCCEEE	36.42	-
18	Sumoylation	ELPLVPVKRQRHELL CCCCCCCCCCCCEEE	36.42	28112733
18	Ubiquitination	ELPLVPVKRQRHELL CCCCCCCCCCCCEEE	36.42	-
21	Asymmetric dimethylarginine	LVPVKRQRHELLLGA CCCCCCCCCEEEECC	29.31	-
21	Methylation	LVPVKRQRHELLLGA CCCCCCCCCEEEECC	29.31	30761547
30	Phosphorylation	ELLLGAGSGPGAGQQ EEEECCCCCCCCCCC	41.08	28555341
40	Phosphorylation	GAGQQQATPGALLQA CCCCCCCCCCHHHHC	20.23	29978859
73	Acetylation	EGEVYCCKFHPNGST CCEEEEEEECCCCCC	43.05	26051181
109	Phosphorylation	YATLKGHSGAVMELH CEECCCCCCEEEEEE	36.80	20068231
119	Phosphorylation	VMELHYNTDGSMLFS EEEEEECCCCCEEEE	34.27	20068231
122	Phosphorylation	LHYNTDGSMLFSAST EEECCCCCEEEEECC	18.34	20068231
126	Phosphorylation	TDGSMLFSASTDKTV CCCCEEEEECCCCEE	19.83	20068231
128	Phosphorylation	GSMLFSASTDKTVAV CCEEEEECCCCEEEE	35.62	20068231
129	Phosphorylation	SMLFSASTDKTVAVW CEEEEECCCCEEEEE	41.03	20068231
132	Phosphorylation	FSASTDKTVAVWDSE EEECCCCEEEEEECC	19.26	24114839
138	Phosphorylation	KTVAVWDSETGERVK CEEEEEECCCCCHHH	22.73	-
140	Phosphorylation	VAVWDSETGERVKRL EEEEECCCCCHHHHH	48.58	24114839
145	Ubiquitination	SETGERVKRLKGHTS CCCCCHHHHHCCCCC	59.23	-
148	Ubiquitination	GERVKRLKGHTSFVN CCHHHHHCCCCCCHH	53.32	-
148	Methylation	GERVKRLKGHTSFVN CCHHHHHCCCCCCHH	53.32	83044565
148	Ubiquitination	GERVKRLKGHTSFVN CCHHHHHCCCCCCHH	53.32	-
156	Phosphorylation	GHTSFVNSCYPARRG CCCCCHHHCCCCCCC	15.10	28152594
158	Phosphorylation	TSFVNSCYPARRGPQ CCCHHHCCCCCCCCE	10.35	28152594
169	Phosphorylation	RGPQLVCTGSDDGTV CCCEEEEECCCCCCE	32.04	21406692
171	Phosphorylation	PQLVCTGSDDGTVKL CEEEEECCCCCCEEE	17.86	21406692
175	Phosphorylation	CTGSDDGTVKLWDIR EECCCCCCEEEEEHH	22.82	21406692
177	Ubiquitination	GSDDGTVKLWDIRKK CCCCCCEEEEEHHHH	43.64	-
177	Acetylation	GSDDGTVKLWDIRKK CCCCCCEEEEEHHHH	43.64	26051181
177	Ubiquitination	GSDDGTVKLWDIRKK CCCCCCEEEEEHHHH	43.64	-
226	Ubiquitination	VWDLRQNKLTYTMRG EEECCCCCCEEEECC	33.59	-
226	Acetylation	VWDLRQNKLTYTMRG EEECCCCCCEEEECC	33.59	25953088
226	Ubiquitination	VWDLRQNKLTYTMRG EEECCCCCCEEEECC	33.59	-
228	Phosphorylation	DLRQNKLTYTMRGHA ECCCCCCEEEECCCC	20.68	20860994
230	Phosphorylation	RQNKLTYTMRGHADS CCCCCEEEECCCCCC	8.65	20860994
265	Methylation	TVRVWDVRPFAPKER CEEEEECCCCCCHHH	20.39	115920001
270	Acetylation	DVRPFAPKERCVKIF ECCCCCCHHHEEEEE	55.12	-
270	Sumoylation	DVRPFAPKERCVKIF ECCCCCCHHHEEEEE	55.12	28112733
270	Acetylation	DVRPFAPKERCVKIF ECCCCCCHHHEEEEE	55.12	23236377
270	Ubiquitination	DVRPFAPKERCVKIF ECCCCCCHHHEEEEE	55.12	21890473
275	Ubiquitination	APKERCVKIFQGNVH CCHHHEEEEECCCCC	41.24	-
275	Acetylation	APKERCVKIFQGNVH CCHHHEEEEECCCCC	41.24	26051181
275	Ubiquitination	APKERCVKIFQGNVH CCHHHEEEEECCCCC	41.24	-
286	Ubiquitination	GNVHNFEKNLLRCSW CCCCCHHHCEEEEEE	49.08	-
286	Ubiquitination	GNVHNFEKNLLRCSW CCCCCHHHCEEEEEE	49.08	-
286	2-Hydroxyisobutyrylation	GNVHNFEKNLLRCSW CCCCCHHHCEEEEEE	49.08	-
286	Acetylation	GNVHNFEKNLLRCSW CCCCCHHHCEEEEEE	49.08	25825284
294	Phosphorylation	NLLRCSWSPDGSKIA CEEEEEECCCCCCCC	9.23	25159151
299	Ubiquitination	SWSPDGSKIAAGSAD EECCCCCCCCCCCCC	41.72	-
299	Acetylation	SWSPDGSKIAAGSAD EECCCCCCCCCCCCC	41.72	26051181
299	Ubiquitination	SWSPDGSKIAAGSAD EECCCCCCCCCCCCC	41.72	-
307	Methylation	IAAGSADRFVYVWDT CCCCCCCCEEEEEEC	23.73	115920005
310	Phosphorylation	GSADRFVYVWDTTSR CCCCCEEEEEECCCC	7.97	-
317	Methylation	YVWDTTSRRILYKLP EEEECCCCEEEEECC	27.80	115920009
322	Ubiquitination	TSRRILYKLPGHAGS CCCEEEEECCCCCCC	44.77	-
322	Acetylation	TSRRILYKLPGHAGS CCCEEEEECCCCCCC	44.77	26051181
329	Phosphorylation	KLPGHAGSINEVAFH ECCCCCCCEEEEEEC	24.03	20873877
344	Phosphorylation	PDEPIIISASSDKRL CCCCEEEEECCCCCE	16.22	20873877
346	Phosphorylation	EPIIISASSDKRLYM CCEEEEECCCCCEEC	32.07	20873877
347	Phosphorylation	PIIISASSDKRLYMG CEEEEECCCCCEECE	47.03	20873877
349	Acetylation	IISASSDKRLYMGEI EEEECCCCCEECEEC	46.37	25953088
349	2-Hydroxyisobutyrylation	IISASSDKRLYMGEI EEEECCCCCEECEEC	46.37	-
349	Ubiquitination	IISASSDKRLYMGEI EEEECCCCCEECEEC	46.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNR40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNR40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNR40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP8_HUMAN	PRPF8	physical	17353931
U520_HUMAN	SNRNP200	physical	17353931
U5S1_HUMAN	EFTUD2	physical	17353931
PRP6_HUMAN	PRPF6	physical	17353931
RU2B_HUMAN	SNRPB2	physical	17353931
PFD2_HUMAN	PFDN2	physical	17353931
MAGA6_HUMAN	MAGEA6	physical	17353931
SF3B1_HUMAN	SF3B1	physical	17353931
U5S1_HUMAN	EFTUD2	physical	9774689
PRP8_HUMAN	PRPF8	physical	9774689
WDR5_HUMAN	WDR5	physical	17041588
U5S1_HUMAN	EFTUD2	physical	16723661
U520_HUMAN	SNRNP200	physical	16723661
PRP8_HUMAN	PRPF8	physical	16723661
A4_HUMAN	APP	physical	21832049
U520_HUMAN	SNRNP200	physical	22939629
TBL1X_HUMAN	TBL1X	physical	22939629
PRPF3_HUMAN	PRPF3	physical	26186194
PRP6_HUMAN	PRPF6	physical	26186194
U520_HUMAN	SNRNP200	physical	26186194
PRP8_HUMAN	PRPF8	physical	26186194
TFP11_HUMAN	TFIP11	physical	26186194
U5S1_HUMAN	EFTUD2	physical	26186194
PAXB1_HUMAN	PAXBP1	physical	26186194
PRP31_HUMAN	PRPF31	physical	26186194
SNUT1_HUMAN	SART1	physical	26186194
ECD_HUMAN	ECD	physical	26186194
SMD2_HUMAN	SNRPD2	physical	26186194
CCD12_HUMAN	CCDC12	physical	26186194
PRP16_HUMAN	DHX38	physical	26186194
SNR27_HUMAN	SNRNP27	physical	26186194
ZNHI2_HUMAN	ZNHIT2	physical	26186194
TXN4A_HUMAN	TXNL4A	physical	26186194
CD2B2_HUMAN	CD2BP2	physical	26186194
AQR_HUMAN	AQR	physical	26186194
SMD1_HUMAN	SNRPD1	physical	26186194
ISY1_HUMAN	ISY1	physical	26186194
RBM42_HUMAN	RBM42	physical	26186194
CHD3_HUMAN	CHD3	physical	26344197
CRNL1_HUMAN	CRNKL1	physical	26344197
U5S1_HUMAN	EFTUD2	physical	26344197
RPC3_HUMAN	POLR3C	physical	26344197
PRP8_HUMAN	PRPF8	physical	26344197
U520_HUMAN	SNRNP200	physical	26344197
SREK1_HUMAN	SREK1	physical	26344197
PAXB1_HUMAN	PAXBP1	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
PRP16_HUMAN	DHX38	physical	28514442
ECD_HUMAN	ECD	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
PRP6_HUMAN	PRPF6	physical	28514442
ZNHI2_HUMAN	ZNHIT2	physical	28514442
PRP8_HUMAN	PRPF8	physical	28514442
TXN4A_HUMAN	TXNL4A	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
U5S1_HUMAN	EFTUD2	physical	28514442
SMD2_HUMAN	SNRPD2	physical	28514442
PRP4_HUMAN	PRPF4	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
AAR2_HUMAN	AAR2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.