TBL1X_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBL1X_HUMAN
• UniProt AC: O60907
• Protein Name: F-box-like/WD repeat-containing protein TBL1X
• Gene Name: TBL1X
• Organism: Homo sapiens (Human).
• Sequence Length: 577
• Subcellular Localization: Nucleus. Colocalized with MECP2 to the heterochromatin foci.
• Protein Description: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. [PubMed: 14980219 Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange]
• Protein Sequence: MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	LRGREGGSHFINTSS HCCCCCCCCCCCCCC	26.53	29396449
43	Phosphorylation	GGSHFINTSSPRGEA CCCCCCCCCCCCCCC	26.26	29396449
44	Phosphorylation	GSHFINTSSPRGEAK CCCCCCCCCCCCCCE	33.58	25849741
45	Phosphorylation	SHFINTSSPRGEAKM CCCCCCCCCCCCCEE	19.31	23663014
55	Phosphorylation	GEAKMSITSDEVNFL CCCEEEECHHHHHHH	23.87	-
153	Acetylation	RQQAFREKLAQQQAS HHHHHHHHHHHHHHH	44.88	-
160	Phosphorylation	KLAQQQASAAAAAAA HHHHHHHHHHHHHHH	17.69	24043423
169	Phosphorylation	AAAAAAATAAATAAT HHHHHHHHHHHHHHH	16.47	24043423
173	Phosphorylation	AAATAAATAATTTSA HHHHHHHHHHHHHCC	16.46	24043423
176	Phosphorylation	TAAATAATTTSAGVS HHHHHHHHHHCCCCC	28.30	24043423
177	Phosphorylation	AAATAATTTSAGVSH HHHHHHHHHCCCCCC	17.64	24043423
178	Phosphorylation	AATAATTTSAGVSHQ HHHHHHHHCCCCCCC	16.54	24043423
179	Phosphorylation	ATAATTTSAGVSHQN HHHHHHHCCCCCCCC	22.42	24043423
183	Phosphorylation	TTTSAGVSHQNPSKN HHHCCCCCCCCCCCC	20.59	24043423
188	Phosphorylation	GVSHQNPSKNREATV CCCCCCCCCCCEEEE	50.54	24043423
204	Phosphorylation	GEENRAHSVNNHAKP CCCCCHHCCCCCCCC	26.09	24275748
210	Acetylation	HSVNNHAKPMEIDGE HCCCCCCCCCEECCE	37.03	26051181
222	Phosphorylation	DGEVEIPSSKATVLR CCEEECCCCCCEEEC	50.56	20873877
223	Phosphorylation	GEVEIPSSKATVLRG CEEECCCCCCEEECC	22.43	20873877
226	Phosphorylation	EIPSSKATVLRGHES ECCCCCCEEECCCCC	24.66	22817900
233	Phosphorylation	TVLRGHESEVFICAW EEECCCCCCEEEEEC	33.13	27080861
329	Ubiquitination	ASTLGQHKGPIFALK HHHCCCCCCCEEEEE	59.50	-
340	Ubiquitination	FALKWNRKGNYILSA EEEEECCCCCEEEEE	48.58	-
383	Phosphorylation	DVDWQNNTTFASCST CCCCCCCCEEEEECC	30.73	22817900
442	Ubiquitination	TLKIWSMKQEVCIHD EEEEEEECCCEEEHH	37.48	-
470	Phosphorylation	SPTGPATSNPNSNIM CCCCCCCCCCCCCEE	53.01	22817900
474	Phosphorylation	PATSNPNSNIMLASA CCCCCCCCCEEEEEE	29.05	22817900
498	Phosphorylation	DIERGVCTHTLTKHQ EECCCEEEEEECCCC	18.58	24719451
502	Phosphorylation	GVCTHTLTKHQEPVY CEEEEEECCCCCCEE	27.86	24719451
509	Phosphorylation	TKHQEPVYSVAFSPD CCCCCCEEEEEECCC	14.24	-
518	Ubiquitination	VAFSPDGKYLASGSF EEECCCCCEEECCCC	44.46	-
522	Phosphorylation	PDGKYLASGSFDKCV CCCCEEECCCCCEEE	32.16	20873877
524	Phosphorylation	GKYLASGSFDKCVHI CCEEECCCCCEEEEE	27.98	20873877
527	Methylation	LASGSFDKCVHIWNT EECCCCCEEEEEEEC	35.83	-
560	Sumoylation	CWNARGDKVGASASD EECCCCCCCCCCCCC	45.45	-
560	Sumoylation	CWNARGDKVGASASD EECCCCCCCCCCCCC	45.45	-
564	Phosphorylation	RGDKVGASASDGSVC CCCCCCCCCCCCCEE	23.52	23403867
566	Phosphorylation	DKVGASASDGSVCVL CCCCCCCCCCCEEEE	39.75	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBL1X_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBL1X_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBL1X_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOR1_HUMAN	NCOR1	physical	12628926
NCOR2_HUMAN	NCOR2	physical	12628926
H2B2E_HUMAN	HIST2H2BE	physical	12628926
H2A2A_HUMAN	HIST2H2AA3	physical	12628926
H32_HUMAN	HIST2H3C	physical	12628926
NCOR1_HUMAN	NCOR1	physical	11931768
GPS2_HUMAN	GPS2	physical	11931768
HDAC3_HUMAN	HDAC3	physical	11931768
NCOR2_HUMAN	NCOR2	physical	12502735
NCOR2_HUMAN	NCOR2	physical	10944117
NCOR1_HUMAN	NCOR1	physical	10944117
NCOR2_HUMAN	NCOR2	physical	10809664
NCOR1_HUMAN	NCOR1	physical	10809664
HDAC3_HUMAN	HDAC3	physical	10809664
CYBP_HUMAN	CACYBP	physical	11389839
SKP1_HUMAN	SKP1	physical	11389839
SIAH1_HUMAN	SIAH1	physical	11389839
CTNB1_HUMAN	CTNNB1	physical	11389839
CTBP1_HUMAN	CTBP1	physical	18374649
TBL1R_HUMAN	TBL1XR1	physical	18374649
HAIR_HUMAN	HR	physical	20211142
TBL1R_HUMAN	TBL1XR1	physical	18202150
NCOR1_HUMAN	NCOR1	physical	18202150
HDAC3_HUMAN	HDAC3	physical	18202150
UB2E3_HUMAN	UBE2E3	physical	18202150
EMD_HUMAN	EMD	physical	17620012
GPS2_HUMAN	GPS2	physical	21240272
H2B2E_HUMAN	HIST2H2BE	physical	15601853
TF65_HUMAN	RELA	physical	21189284
CTNB1_HUMAN	CTNNB1	physical	18193033
TBL1X_HUMAN	TBL1X	physical	16258276
SMRD2_HUMAN	SMARCD2	physical	26344197
GPS2_HUMAN	GPS2	physical	26070566
CTNB1_HUMAN	CTNNB1	physical	25241761
UBP44_HUMAN	USP44	physical	27880911
TBL1R_HUMAN	TBL1XR1	physical	27880911
NCOR1_HUMAN	NCOR1	physical	27880911

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.