dbPTM

HAIR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HAIR_HUMAN
UniProt AC	O43593
Protein Name	Lysine-specific demethylase hairless
Gene Name	HR
Organism	Homo sapiens (Human).
Sequence Length	1189
Subcellular Localization	Nucleus.
Protein Description	Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle..
Protein Sequence	MESTPSFLKGTPTWEKTAPENGIVRQEPGSPPRDGLHHGPLCLGEPAPFWRGVLSTPDSWLPPGFPQGPKDMLPLVEGEGPQNGERKVNWLGSKEGLRWKEAMLTHPLAFCGPACPPRCGPLMPEHSGGHLKSDPVAFRPWHCPFLLETKILERAPFWVPTCLPPYLVSGLPPEHPCDWPLTPHPWVYSGGQPKVPSAFSLGSKGFYYKDPSIPRLAKEPLAAAEPGLFGLNSGGHLQRAGEAERPSLHQRDGEMGAGRQQNPCPLFLGQPDTVPWTSWPACPPGLVHTLGNVWAGPGDGNLGYQLGPPATPRCPSPEPPVTQRGCCSSYPPTKGGGLGPCGKCQEGLEGGASGASEPSEEVNKASGPRACPPSHHTKLKKTWLTRHSEQFECPRGCPEVEERPVARLRALKRAGSPEVQGAMGSPAPKRPPDPFPGTAEQGAGGWQEVRDTSIGNKDVDSGQHDEQKGPQDGQASLQDPGLQDIPCLALPAKLAQCQSCAQAAGEGGGHACHSQQVRRSPLGGELQQEEDTATNSSSEEGPGSGPDSRLSTGLAKHLLSGLGDRLCRLLRREREALAWAQREGQGPAVTEDSPGIPRCCSRCHHGLFNTHWRCPRCSHRLCVACGRVAGTGRAREKAGFQEQSAEECTQEAGHAACSLMLTQFVSSQALAELSTAMHQVWVKFDIRGHCPCQADARVWAPGDAGQQKESTQKTPPTPQPSCNGDTHRTKSIKEETPDSAETPAEDRAGRGPLPCPSLCELLASTAVKLCLGHERIHMAFAPVTPALPSDDRITNILDSIIAQVVERKIQEKALGPGLRAGPGLRKGLGLPLSPVRPRLPPPGALLWLQEPQPCPRRGFHLFQEHWRQGQPVLVSGIQRTLQGNLWGTEALGALGGQVQALSPLGPPQPSSLGSTTFWEGFSWPELRPKSDEGSVLLLHRALGDEDTSRVENLAASLPLPEYCALHGKLNLASYLPPGLALRPLEPQLWAAYGVSPHRGHLGTKNLCVEVADLVSILVHADTPLPAWHRAQKDFLSGLDGEGLWSPGSQVSTVWHVFRAQDAQRIRRFLQMVCPAGAGALEPGAPGSCYLDAGLRRRLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTVSVTQHFLSPETSALSAQLCHQGPSLPPDCHLLYAQMDWAVFQAVKVAVGTLQEAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MESTPSFLKGT ----CCCCCCHHCCC	26.66	23403867
6	Phosphorylation	--MESTPSFLKGTPT --CCCCCCHHCCCCC	43.21	19664994
30	Phosphorylation	IVRQEPGSPPRDGLH CCCCCCCCCCCCCCC	42.31	24719451
87	Ubiquitination	GPQNGERKVNWLGSK CCCCCCCCCCCCCCH	35.30	29967540
127	Phosphorylation	GPLMPEHSGGHLKSD CCCCCCCCCCCCCCC	44.82	30631047
149	Phosphorylation	HCPFLLETKILERAP CCCCCEECCHHHHCC	24.29	20068231
316	Phosphorylation	PATPRCPSPEPPVTQ CCCCCCCCCCCCCCC	45.59	28985074
416	Phosphorylation	RALKRAGSPEVQGAM HHHHHCCCHHHCCCC	19.53	29255136
425	Phosphorylation	EVQGAMGSPAPKRPP HHCCCCCCCCCCCCC	12.57	27732954
520	Phosphorylation	HSQQVRRSPLGGELQ CCCCHHCCCCCCCCC	17.57	26657352
574	Methylation	CRLLRREREALAWAQ HHHHHHHHHHHHHHH	32.45	115479669
601	Phosphorylation	PGIPRCCSRCHHGLF CCCCCCCHHCCCCCC	41.38	-
610	Phosphorylation	CHHGLFNTHWRCPRC CCCCCCCCCCCCCCC	18.58	-
631	Phosphorylation	ACGRVAGTGRAREKA HCCCCCCCCHHHHHH	17.47	-
708	Ubiquitination	PGDAGQQKESTQKTP CCCCCCCCCCCCCCC	45.83	29967540
733	Sumoylation	THRTKSIKEETPDSA CCCCCCCCCCCCCCC	57.50	-
733	Sumoylation	THRTKSIKEETPDSA CCCCCCCCCCCCCCC	57.50	-
812	Ubiquitination	VERKIQEKALGPGLR HHHHHHHHHHCCCCC	32.32	29967540
833	Phosphorylation	KGLGLPLSPVRPRLP CCCCCCCCCCCCCCC	21.29	29802988

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HAIR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HAIR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HAIR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THA_HUMAN	THRA	physical	11641275
HDAC1_HUMAN	HDAC1	physical	19819974
P53_HUMAN	TP53	physical	27355563

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
203655	Alopecia universalis congenita (ALUNC)
209500	Atrichia with papular lesions (APL)
146550	Hypotrichosis 4 (HYPT4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HAIR_HUMAN

Related Literatures of Post-Translational Modification