TXN4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXN4A_HUMAN
• UniProt AC: P83876
• Protein Name: Thioredoxin-like protein 4A
• Gene Name: TXNL4A
• Organism: Homo sapiens (Human).
• Sequence Length: 142
• Subcellular Localization: Nucleus .
• Protein Description: Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly..
• Protein Sequence: MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	MKMDEVLYSIAEKVK HCHHHHHHHHHHHHC	11.82	-
47	Phosphorylation	KMDEVLYSIAEKVKN CHHHHHHHHHHHHCC	15.91	-
51	Ubiquitination	VLYSIAEKVKNFAVI HHHHHHHHHCCEEEE	49.87	21890473
51	Acetylation	VLYSIAEKVKNFAVI HHHHHHHHHCCEEEE	49.87	25953088
73	Phosphorylation	VPDFNKMYELYDPCT CCCHHHHHHHCCCCE	12.37	22817900
76	Phosphorylation	FNKMYELYDPCTVMF HHHHHHHCCCCEEEE	13.10	-
132	Phosphorylation	KGRGLVVSPKDYSTK CCCCEEECCCCCCCC	20.82	23401153
132	O-linked_Glycosylation	KGRGLVVSPKDYSTK CCCCEEECCCCCCCC	20.82	29351928
134	Ubiquitination	RGLVVSPKDYSTKYR CCEEECCCCCCCCCC	62.89	21890473
136	Phosphorylation	LVVSPKDYSTKYRY- EEECCCCCCCCCCC-	25.11	26270265
137	Phosphorylation	VVSPKDYSTKYRY-- EECCCCCCCCCCC--	28.67	23312004
138	Phosphorylation	VSPKDYSTKYRY--- ECCCCCCCCCCC---	26.35	26270265
139	Ubiquitination	SPKDYSTKYRY---- CCCCCCCCCCC----	23.07	21890473
139	Acetylation	SPKDYSTKYRY---- CCCCCCCCCCC----	23.07	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXN4A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXN4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXN4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
REBL1_HUMAN	RHEBL1	physical	16189514
HNRPF_HUMAN	HNRNPF	physical	11054566
PQBP1_HUMAN	PQBP1	physical	11054566
PRP6_HUMAN	PRPF6	physical	16723661
WDFY1_HUMAN	WDFY1	physical	22939629
LZTS2_HUMAN	LZTS2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608572: Burn-McKeown syndrome (BMKS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.
PubMed: 18669648