REBL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REBL1_HUMAN
• UniProt AC: Q8TAI7
• Protein Name: GTPase RhebL1
• Gene Name: RHEBL1
• Organism: Homo sapiens (Human).
• Sequence Length: 183
• Subcellular Localization: Endomembrane system ; Lipid-anchor ; Cytoplasmic side . Cytoplasm .
• Protein Description: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2..
• Protein Sequence: MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVDTAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNKADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRCHLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
107	Ubiquitination	YQKLHEGHGKTRVPV HHHHHCCCCCCCCEE	31.43	29967540
109	Ubiquitination	KLHEGHGKTRVPVVL HHHCCCCCCCCEEEE	27.73	29967540
118	Ubiquitination	RVPVVLVGNKADLSP CCEEEEECCCCCCCH	26.26	29967540
120	Ubiquitination	PVVLVGNKADLSPER EEEEECCCCCCCHHH	37.03	29967540
124	Phosphorylation	VGNKADLSPEREVQA ECCCCCCCHHHHHHH	25.84	24719451
162	Ubiquitination	LTQGIFTKVIQEIAR HHHHHHHHHHHHHHH	26.96	-
180	Methylation	SYGQERRCHLM---- HCCCCCCCCCC----	3.46	-
180	Farnesylation	SYGQERRCHLM---- HCCCCCCCCCC----	3.46	16006564
180	Farnesylation	SYGQERRCHLM---- HCCCCCCCCCC----	3.46	16006564

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REBL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REBL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REBL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF2_HUMAN	TRAF2	physical	20368287
DP13A_MOUSE	Appl1	physical	20368287
GO45_MOUSE	Blzf1	physical	20368287
TRAF2_MOUSE	Traf2	physical	20368287
TXN4A_HUMAN	TXNL4A	physical	20368287
FHL3_HUMAN	FHL3	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Prenylation

"The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib)inhibits Rheb farnesylation and mTOR signaling. Role in FTIenhancement of taxane and tamoxifen anti-tumor activity.";
Basso A.D., Mirza A., Liu G., Long B.J., Bishop W.R., Kirschmeier P.;
J. Biol. Chem. 280:31101-31108(2005).
Cited for: TISSUE SPECIFICITY, AND ISOPRENYLATION AT CYS-180.
PubMed: 16006564