MAGA6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGA6_HUMAN
• UniProt AC: P43360
• Protein Name: Melanoma-associated antigen 6
• Gene Name: MAGEA6
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Protein Description: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines..
• Protein Sequence: MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPLEQRSQHCKPEE -CCHHHHHHCCCHHH	24.78	26434776
11	Ubiquitination	EQRSQHCKPEEGLEA HHHHHCCCHHHHHHH	54.03	-
11	Sumoylation	EQRSQHCKPEEGLEA HHHHHCCCHHHHHHH	54.03	-
11	Sumoylation	EQRSQHCKPEEGLEA HHHHHCCCHHHHHHH	54.03	-
115	Ubiquitination	ALSRKVAKLVHFLLL HHHHHHHHHHHHHHH	54.77	29967540
124	Phosphorylation	VHFLLLKYRAREPVT HHHHHHHHHCCCCCC	14.96	-
132	Ubiquitination	RAREPVTKAEMLGSV HCCCCCCHHHHHHHH	42.45	21987572
152	Phosphorylation	YFFPVIFSKASDSLQ HEEEEEEECCCCHHH	19.05	24719451
220	Ubiquitination	GDCAPEEKIWEELSV CCCCCHHHHHHHHCH	52.00	22817900
243	Ubiquitination	DSIFGDPKKLLTQYF CCCCCCHHHHHHHHH	61.87	23000965
244	Ubiquitination	SIFGDPKKLLTQYFV CCCCCHHHHHHHHHH	54.86	23000965
247	Phosphorylation	GDPKKLLTQYFVQEN CCHHHHHHHHHHHHC	31.49	24719451
249	Phosphorylation	PKKLLTQYFVQENYL HHHHHHHHHHHHCCC	10.65	24719451
255	Phosphorylation	QYFVQENYLEYRQVP HHHHHHCCCCHHCCC	10.52	-
258	Phosphorylation	VQENYLEYRQVPGSD HHHCCCCHHCCCCCC	12.07	-
285	Ubiquitination	LIETSYVKVLHHMVK HHHHHHHHHHHHHHH	30.74	22817900
292	Ubiquitination	KVLHHMVKISGGPRI HHHHHHHHHCCCCCC	24.47	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	DCAF12	Q5T6F0	PMID:31267705

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGA6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LPPRC_HUMAN	LRPPRC	physical	17353931
GCN1_HUMAN	GCN1L1	physical	17353931
OST48_HUMAN	DDOST	physical	17353931
IF4G2_HUMAN	EIF4G2	physical	17353931
CCAR2_HUMAN	CCAR2	physical	17353931
XPO5_HUMAN	XPO5	physical	17353931
IF4G1_HUMAN	EIF4G1	physical	17353931
DAAF5_HUMAN	DNAAF5	physical	17353931
VIGLN_HUMAN	HDLBP	physical	17353931
TIF1B_HUMAN	TRIM28	physical	20864041
PDE4D_HUMAN	PDE4D	physical	25416956
RL37A_HUMAN	RPL37A	physical	25416956
STX5_HUMAN	STX5	physical	25416956
TULP3_HUMAN	TULP3	physical	25416956
NCK2_HUMAN	NCK2	physical	25416956
SNX4_HUMAN	SNX4	physical	25416956
BCL7B_HUMAN	BCL7B	physical	25416956
VATG1_HUMAN	ATP6V1G1	physical	25416956
AKAP9_HUMAN	AKAP9	physical	25416956
TXND9_HUMAN	TXNDC9	physical	25416956
BET1_HUMAN	BET1	physical	25416956
EXOC5_HUMAN	EXOC5	physical	25416956
BACH_HUMAN	ACOT7	physical	25416956
FRPD1_HUMAN	FRMPD1	physical	25416956
GFOD1_HUMAN	GFOD1	physical	25416956
RCOR3_HUMAN	RCOR3	physical	25416956
LIN37_HUMAN	LIN37	physical	25416956
F214A_HUMAN	FAM214A	physical	25416956
S10AE_HUMAN	S100A14	physical	25416956
STALP_HUMAN	STAMBPL1	physical	25416956
CC146_HUMAN	CCDC146	physical	25416956
LSM2_HUMAN	LSM2	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
RASF4_HUMAN	RASSF4	physical	25416956
ELMD3_HUMAN	ELMOD3	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
SNP47_HUMAN	SNAP47	physical	25416956
MIPO1_HUMAN	MIPOL1	physical	25416956
IQUB_HUMAN	IQUB	physical	25416956
LCORL_HUMAN	LCORL	physical	25416956
MORN3_HUMAN	MORN3	physical	25416956
KLH38_HUMAN	KLHL38	physical	25416956
TRI26_HUMAN	TRIM26	physical	21516116
ATPF2_HUMAN	ATPAF2	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.