RASF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RASF4_HUMAN
• UniProt AC: Q9H2L5
• Protein Name: Ras association domain-containing protein 4
• Gene Name: RASSF4
• Organism: Homo sapiens (Human).
• Sequence Length: 321
• Protein Description: Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest..
• Protein Sequence: MKEDCLPSSHVPISDSKSIQKSELLGLLKTYNCYHEGKSFQLRHREEEGTLIIEGLLNIAWGLRRPIRLQMQDDREQVHLPSTSWMPRRPSCPLKEPSPQNGNITAQGPSIQPVHKAESSTDSSGPLEEAEEAPQLMRTKSDASCMSQRRPKCRAPGEAQRIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSEFALYIVHESGERTKLKDCEYPLISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQLVEAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Ubiquitination	SDSKSIQKSELLGLL CCCCCCCHHHHHHHH	44.20	29967540
22	Phosphorylation	DSKSIQKSELLGLLK CCCCCCHHHHHHHHH	19.66	28842319
30	Phosphorylation	ELLGLLKTYNCYHEG HHHHHHHHHCCCCCC	21.67	28842319
34	Phosphorylation	LLKTYNCYHEGKSFQ HHHHHCCCCCCCCEE	10.16	28842319
39	Phosphorylation	NCYHEGKSFQLRHRE CCCCCCCCEECCCCC	29.14	28842319
50	Phosphorylation	RHREEEGTLIIEGLL CCCCCCCCEEEEHHH	20.33	22210691
82	Phosphorylation	REQVHLPSTSWMPRR CCCCCCCCCCCCCCC	41.24	28387310
91	Phosphorylation	SWMPRRPSCPLKEPS CCCCCCCCCCCCCCC	26.93	28450419
98	Phosphorylation	SCPLKEPSPQNGNIT CCCCCCCCCCCCCCC	39.96	28450419
120	Phosphorylation	PVHKAESSTDSSGPL CCEECCCCCCCCCCH	27.95	30576142
124	Phosphorylation	AESSTDSSGPLEEAE CCCCCCCCCCHHHHH	47.44	30576142
141	Phosphorylation	PQLMRTKSDASCMSQ HHHHHCCCHHHHHHC	37.48	28857561
168	Phosphorylation	RIRRHRFSINGHFYN HHHHCCEEECCEECC	18.33	23401153
178	Phosphorylation	GHFYNHKTSVFTPAY CEECCCCCCEEECCC	23.67	28857561
179	Phosphorylation	HFYNHKTSVFTPAYG EECCCCCCEEECCCC	21.75	28857561
182	Phosphorylation	NHKTSVFTPAYGSVT CCCCCEEECCCCCEE	12.59	30108239
185	Phosphorylation	TSVFTPAYGSVTNVR CCEEECCCCCEECEE	15.90	30108239
187	Phosphorylation	VFTPAYGSVTNVRVN EEECCCCCEECEECC	17.06	28857561
189	Phosphorylation	TPAYGSVTNVRVNST ECCCCCEECEECCCH	29.69	30108239
199	Phosphorylation	RVNSTMTTLQVLTLL ECCCHHHHHHHHHHH	12.36	30576142
232	Methylation	HESGERTKLKDCEYP ECCCCCCCCCCCCCH	60.81	23644510
283	Phosphorylation	FEMPVLDSFVEKLKE CCHHHHHHHHHHHHH	27.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RASF4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RASF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RASF4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STK4_HUMAN	STK4	physical	24366813
STK3_HUMAN	STK3	physical	24366813

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.