F214A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F214A_HUMAN
• UniProt AC: Q32MH5
• Protein Name: Protein FAM214A
• Gene Name: FAM214A
• Organism: Homo sapiens (Human).
• Sequence Length: 1076
• Protein Sequence: MKPDRDTLDEYFEYDAEEFLVSLALLITEGRTPECSVKGRTESFHCPPAQSCYPVTTKHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEMMLLPDCCYSDDGPTTEGIDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKTLLLAVRSFVFFSQLSAWLSVSHGAIPRNILYRISAADVDLQWNFSQTPIEHVFPVPNVSHNVALKVSVQSLPRQSNYPVLTCSIHTNIGLYEKRIQQHKLKTHQHHNPNEAEQCGTNSSQRLCSKQTWTMAPESVLHAKSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIKSQETSVRTLKSFSMVDSSISNRQSFWQSAGETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVSGRPFNTQESSSLHSKLFRVSQENENVGKGKEAFSMTFGSPEFSSPEDTNEGKIRLKPETPRSETCISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSFNMHDSSSVASKVFRSSYEDKNLLKKNKDESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTRNQCQNNPSEIIQSTYQETQNKSSSLSTSSILSQHKENNLDLTSRFKEQEMSNGIDKQYSNCTTIDKQICTNKYKEKIINENYNPKFFGNLQSDDSKKNDSKIKVTVLEMSEYLNKYESMSSNKDSKRPKTCEQNTQLNSIENYLNKDNEGFKCKKSDQLKNEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNTEVLRTTLKHSNVWRKHNFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDSSLLHLKSFSSRSPRPCLNIEDDPDIHEKPFLSSSAPPITSLSLLGNFEESVLNYRFDPLGIVDGFTAEVGASGAFCPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMFVVIYDLRDMPANHQTFLRQRTFSVPVKQEVKRSVNKENIRHTEERLLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Ubiquitination	TKHECSDKLAQCRQA CHHHHHHHHHHHHHH	29.45	29967540
71 (in isoform 3)	Ubiquitination	-	5.42	-
71	Ubiquitination	KLAQCRQARRTRSEV HHHHHHHHHHHHHHH	5.42	29967540
269	Phosphorylation	NSSQRLCSKQTWTMA CHHHHHCCCCCEECC	32.18	29507054
272	Phosphorylation	QRLCSKQTWTMAPES HHHCCCCCEECCCHH	27.00	24719451
274	Phosphorylation	LCSKQTWTMAPESVL HCCCCCEECCCHHHH	13.57	29507054
279	Phosphorylation	TWTMAPESVLHAKSG CEECCCHHHHHCCCC	28.99	29507054
291	Phosphorylation	KSGPSPEYTAAVKNI CCCCCHHHHEEEEEE	12.69	24719451
292	Phosphorylation	SGPSPEYTAAVKNIK CCCCHHHHEEEEEEE	13.38	24719451
296	Ubiquitination	PEYTAAVKNIKLYPG HHHHEEEEEEEEECC	48.50	33845483
299	Ubiquitination	TAAVKNIKLYPGTGS HEEEEEEEEECCCCC	51.89	33845483
303	Ubiquitination	KNIKLYPGTGSKSDH EEEEEECCCCCCCCC	29.20	33845483
303 (in isoform 3)	Ubiquitination	-	29.20	-
306	Ubiquitination	KLYPGTGSKSDHGTS EEECCCCCCCCCCCC	28.91	33845483
306 (in isoform 3)	Ubiquitination	-	28.91	-
327	Ubiquitination	FSGIGDIKSQETSVR CCCCCCCCCCCCCHH	51.32	29967540
332	Phosphorylation	DIKSQETSVRTLKSF CCCCCCCCHHHCHHH	14.62	20860994
334	Ubiquitination	KSQETSVRTLKSFSM CCCCCCHHHCHHHCC	33.82	29967540
335	Phosphorylation	SQETSVRTLKSFSMV CCCCCHHHCHHHCCC	36.06	20860994
337	Ubiquitination	ETSVRTLKSFSMVDS CCCHHHCHHHCCCCC	49.17	-
338	Phosphorylation	TSVRTLKSFSMVDSS CCHHHCHHHCCCCCC	26.18	25954137
340	Phosphorylation	VRTLKSFSMVDSSIS HHHCHHHCCCCCCHH	25.61	25954137
344 (in isoform 3)	Ubiquitination	-	20.40	-
344	Phosphorylation	KSFSMVDSSISNRQS HHHCCCCCCHHCCHH	20.40	22964224
345	Phosphorylation	SFSMVDSSISNRQSF HHCCCCCCHHCCHHH	26.10	22964224
347	Phosphorylation	SMVDSSISNRQSFWQ CCCCCCHHCCHHHHH	28.10	25954137
388	Phosphorylation	LIHCDPSTSHVSGRP HHHCCCCCCCCCCCC	28.39	-
389	Phosphorylation	IHCDPSTSHVSGRPF HHCCCCCCCCCCCCC	26.65	-
402	Phosphorylation	PFNTQESSSLHSKLF CCCCCCCHHHHHHHH	35.85	-
422	Acetylation	NENVGKGKEAFSMTF CCCCCCCHHHHEEEE	49.72	19813609
513	Phosphorylation	QSFNMHDSSSVASKV CCCCCCCCHHHHHHH	15.16	24719451
518	Phosphorylation	HDSSSVASKVFRSSY CCCHHHHHHHHHCHH	27.48	-
524	Phosphorylation	ASKVFRSSYEDKNLL HHHHHHCHHHCHHHH	28.43	24719451
546	Ubiquitination	SVSISHTKCSLLGDI CCEEECCEECCCCCC	19.19	29967540
553	Ubiquitination	KCSLLGDISDGKNLV EECCCCCCCCCCCCC	3.72	29967540
577	Phosphorylation	NNSKEKCSLKHQTRN CCCHHCCHHHHHCHH	52.07	24719451
582	Phosphorylation	KCSLKHQTRNQCQNN CCHHHHHCHHHHHCC	31.16	24719451
605	Phosphorylation	YQETQNKSSSLSTSS HHHHCCCCCCCCHHH	32.48	-
606	Phosphorylation	QETQNKSSSLSTSSI HHHCCCCCCCCHHHH	36.59	-
607	Phosphorylation	ETQNKSSSLSTSSIL HHCCCCCCCCHHHHH	33.17	-
615	Phosphorylation	LSTSSILSQHKENNL CCHHHHHHHHHHHCC	28.68	-
618	Ubiquitination	SSILSQHKENNLDLT HHHHHHHHHHCCCHH	55.27	29967540
625	Ubiquitination	KENNLDLTSRFKEQE HHHCCCHHHHHHHHH	19.95	29967540
665	Phosphorylation	EKIINENYNPKFFGN HHHCCCCCCCCCCCC	27.02	-
729	Ubiquitination	SIENYLNKDNEGFKC HHHHHHCCCCCCCCC	60.37	29967540
736	Ubiquitination	KDNEGFKCKKSDQLK CCCCCCCCCCHHHHC	6.65	29967540
767	Ubiquitination	YSQRRSIKDCLSTCE HHHHHCHHHHHHHCC	43.57	29967540
774	Ubiquitination	KDCLSTCEQPKNTEV HHHHHHCCCCCCHHH	70.75	29967540
794	Ubiquitination	KHSNVWRKHNFHSLD HCCCCCCCCCCCCCC	27.47	29967540
799	Phosphorylation	WRKHNFHSLDGTSTR CCCCCCCCCCCCCCC	24.82	28348404
801	Ubiquitination	KHNFHSLDGTSTRAF CCCCCCCCCCCCCEE	62.43	29967540
818	Phosphorylation	QTGLPLLSSPVPQRK CCCCCCCCCCCCCCC	40.03	28348404
819	Phosphorylation	TGLPLLSSPVPQRKT CCCCCCCCCCCCCCC	29.86	28348404
949	Phosphorylation	ESLGKRGYRVPPSGT HHCCCCCCCCCCCCC	16.69	-
960	Phosphorylation	PSGTIQVTLFNPNKT CCCCEEEEEECCCCE	14.84	-
992	Ubiquitination	HQTFLRQRTFSVPVK CHHHHHHCCCCCCCC	31.16	22505724
1008	Ubiquitination	EVKRSVNKENIRHTE HHHHHCCHHHHCCHH	50.40	22505724
1015	Ubiquitination	KENIRHTEERLLRYL HHHHCCHHHHHHHHH	34.69	22505724
1021	Phosphorylation	TEERLLRYLIHLRFQ HHHHHHHHHHHHHHC	15.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F214A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F214A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F214A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADIP_HUMAN	SSX2IP	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.