FRPD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRPD1_HUMAN
• UniProt AC: Q5SYB0
• Protein Name: FERM and PDZ domain-containing protein 1
• Gene Name: FRMPD1
• Organism: Homo sapiens (Human).
• Sequence Length: 1578
• Subcellular Localization: Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Found both in the cytoplasm and associated with the cell membrane.
• Protein Description: Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1..
• Protein Sequence: MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKIDKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTALTAAVFCLTQKFRASTAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
171	Phosphorylation	EVLISGHSQGNSLLC EEEECCCCCCCEEEE	43.22	22210691
192	Phosphorylation	LYLENGQTKAFKFEA HHHHCCCEEEEEEEC	26.24	22210691
209	Phosphorylation	TVKDIILTVKEKLSI CHHHHHEEEHHHHCH	21.08	-
215	Phosphorylation	LTVKEKLSIRSIEYF EEEHHHHCHHHHHHH	27.33	-
253	Phosphorylation	QVVEREESHDYRCLF HHHHHHHHCCCEEEE	19.53	24114839
318	Phosphorylation	LHIQERIYACAQPQK HHHHHHHHHHCCCCE	11.23	-
330	Phosphorylation	PQKISLKYIEKDWGI CCEEEEEEHHHHHCC	21.43	22210691
342	Phosphorylation	WGIENFISPTLLRNM HCCCCCCCHHHHHHC	14.01	23403867
344	Phosphorylation	IENFISPTLLRNMKG CCCCCCHHHHHHCCC	31.47	23403867
378	Phosphorylation	PRQKQLISAAQLRLN HHHHHHHHHHHHHHH	26.58	26330541
395	Phosphorylation	QILGELKTYGGRIFN HHHHHHHHHCCEEEE	39.77	23403867
396	Phosphorylation	ILGELKTYGGRIFNA HHHHHHHHCCEEEEE	18.92	23403867
404	Phosphorylation	GGRIFNATLMLQDRE CCEEEEEEEEECCHH	17.50	23403867
552	Phosphorylation	VKLAPCRSLIKEEQP EECCCHHHHHCCCCC	40.96	24719451
565	Phosphorylation	QPPGNSPTPEVARRG CCCCCCCCHHHHHCC	31.72	30576142
574	Phosphorylation	EVARRGPSTCGASST HHHHCCCCCCCCCCC	38.87	22210691
579	Phosphorylation	GPSTCGASSTTDSAE CCCCCCCCCCCCCCC	17.32	30576142
580	Phosphorylation	PSTCGASSTTDSAES CCCCCCCCCCCCCCH	34.49	22210691
581	Phosphorylation	STCGASSTTDSAESE CCCCCCCCCCCCCHH	31.93	30576142
587	Phosphorylation	STTDSAESEASDSAN CCCCCCCHHHCCCCC	37.87	30576142
590	Phosphorylation	DSAESEASDSANTES CCCCHHHCCCCCCCC	28.22	30576142
779	Phosphorylation	YDAADKLTPPGPPSG HHHHHHCCCCCCCCC	32.93	26657352
829	Acetylation	PSRRGGVKKYAKTLR CCCCCCHHHHHHHHH	43.26	24884155
846	Phosphorylation	RSFLQTDYTSQVSFP HHHHCCCCCCCCCCC	16.21	-
868	Phosphorylation	ESVDDVCYYDREPYL CCCCEEEECCCCCCH	14.30	-
869	Phosphorylation	SVDDVCYYDREPYLA CCCEEEECCCCCCHH	11.91	-
932	Phosphorylation	PETMETKSVIDSRVS CCHHCCHHHHCHHHH	31.55	-
940	Phosphorylation	VIDSRVSSISAIRFR HHCHHHHCEEEEEEE	20.08	-
1071	Phosphorylation	IQETAPKYTEPLLSP HHHCCCCCCCCCCCC	18.44	28152594
1072	Phosphorylation	QETAPKYTEPLLSPR HHCCCCCCCCCCCCC	36.93	28152594
1077	Phosphorylation	KYTEPLLSPRDEPRS CCCCCCCCCCCCCCC	26.10	24719451
1117	Phosphorylation	LERDREVTNKNGTNV CCCCHHHCCCCCCCC	35.40	28509920
1122	Phosphorylation	EVTNKNGTNVFQEES HHCCCCCCCCCCHHH	37.29	28509920
1152	Phosphorylation	SQTLDISSPAGKIVT HCEEECCCCCCEEEE	21.07	24260401
1290	Phosphorylation	DSSSICLSAEKSFLC CCCCEEEEECCEEEE	29.94	26091039
1307	Phosphorylation	PESHPEVSASLRVAT CCCCHHHHHHHHHHH	15.52	24905233
1309	Phosphorylation	SHPEVSASLRVATSL CCHHHHHHHHHHHHH	14.81	24905233
1529	Phosphorylation	GNLRDVVYTYHQFIE HCHHHHHHHHHHHHH	11.05	25262027
1530	Phosphorylation	NLRDVVYTYHQFIEA CHHHHHHHHHHHHHH	11.69	25262027
1531	Phosphorylation	LRDVVYTYHQFIEAA HHHHHHHHHHHHHHH	3.96	25262027

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRPD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRPD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRPD1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FRPD1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.