TULP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TULP3_HUMAN
• UniProt AC: O75386
• Protein Name: Tubby-related protein 3
• Gene Name: TULP3
• Organism: Homo sapiens (Human).
• Sequence Length: 442
• Subcellular Localization: Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm. Secreted. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guan
• Protein Description: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis..
• Protein Sequence: MEASRCRLSPSGDSVFHEEMMKMRQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNCHTPHSNVILHGIDGPAAVLKPDEVHAPSVSSSVVEEDAENTVDTASKPGLQERLQKHDISESVNFDEETDGISQSACLERPNSASSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLMGTKFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFDSKLACE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	EASRCRLSPSGDSVF CCCCCCCCCCCCCHH	9.54	25159151
11	Phosphorylation	SRCRLSPSGDSVFHE CCCCCCCCCCCHHHH	52.43	30576142
14	Phosphorylation	RLSPSGDSVFHEEMM CCCCCCCCHHHHHHH	30.15	29978859
27	Ubiquitination	MMKMRQAKLDYQRLL HHHHHHHHHHHHHHH	33.29	-
30	Phosphorylation	MRQAKLDYQRLLLEK HHHHHHHHHHHHHHH	13.13	-
245	Ubiquitination	ARKRKKSKTANYLIS EHHHCCCCCCCEEEE	61.61	21890473
245	Ubiquitination	ARKRKKSKTANYLIS EHHHCCCCCCCEEEE	61.61	21890473
245	Ubiquitination	ARKRKKSKTANYLIS EHHHCCCCCCCEEEE	61.61	-
268	Ubiquitination	EGESYVGKLRSNLMG CCCHHHHHHHHCCCC	30.59	-
277	Ubiquitination	RSNLMGTKFTVYDRG HHCCCCCEEEEEECC	33.05	21890473
277	Ubiquitination	RSNLMGTKFTVYDRG HHCCCCCEEEEEECC	33.05	21890473
277	Ubiquitination	RSNLMGTKFTVYDRG HHCCCCCEEEEEECC	33.05	-
291	Methylation	GICPMKGRGLVGAAH CCCCCCCCCCCCCCC	29.74	115919169
316	Ubiquitination	ETNVLGFKGPRKMSV CCCCCCCCCCCCEEE	67.23	21890473
316	Ubiquitination	ETNVLGFKGPRKMSV CCCCCCCCCCCCEEE	67.23	-
316	Ubiquitination	ETNVLGFKGPRKMSV CCCCCCCCCCCCEEE	67.23	21890473
322	Phosphorylation	FKGPRKMSVIIPGMT CCCCCCEEEEECCCC	17.13	22496350
345	Phosphorylation	QPQNNHDSLLSRWQN CCCCCHHHHHHHHHH	24.53	24719451
348	Phosphorylation	NNHDSLLSRWQNRTM CCHHHHHHHHHHHHH	36.44	24719451
441 (in isoform 2)	Phosphorylation	-	10.38	26552605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TULP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TULP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TULP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPIP1_HUMAN	PSTPIP1	physical	25416956
ROP1A_HUMAN	ROPN1	physical	25416956
ANR54_HUMAN	ANKRD54	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
TT21B_HUMAN	TTC21B	physical	28514442
WDR35_HUMAN	WDR35	physical	28514442
ANR54_HUMAN	ANKRD54	physical	28514442
LYSM1_HUMAN	LYSMD1	physical	28514442
WDR19_HUMAN	WDR19	physical	28514442
IF140_HUMAN	IFT140	physical	28514442
ARI1_HUMAN	ARIH1	physical	28514442
FOXK2_HUMAN	FOXK2	physical	28514442
IF122_HUMAN	IFT122	physical	28514442
SIR1_HUMAN	SIRT1	physical	28514442
GNL1_HUMAN	GNL1	physical	28514442
KANL2_HUMAN	KANSL2	physical	28514442
BCR_HUMAN	BCR	physical	28514442
PDLI5_HUMAN	PDLIM5	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
ARI2_HUMAN	ARIH2	physical	28514442
MCRS1_HUMAN	MCRS1	physical	28514442
PML_HUMAN	PML	physical	28514442
MYPT1_HUMAN	PPP1R12A	physical	28514442
KPBB_HUMAN	PHKB	physical	28514442
DCA16_HUMAN	DCAF16	physical	28514442
RAD18_HUMAN	RAD18	physical	28514442
NUMB_HUMAN	NUMB	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
GGPPS_HUMAN	GGPS1	physical	28514442
UBP7_HUMAN	USP7	physical	28514442
WAPL_HUMAN	WAPAL	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
RN138_HUMAN	RNF138	physical	28514442
PI42B_HUMAN	PIP4K2B	physical	28514442
MTMR3_HUMAN	MTMR3	physical	28514442
THNS1_HUMAN	THNSL1	physical	28514442
MK09_HUMAN	MAPK9	physical	28514442
TUB_HUMAN	TUB	physical	28514442
PARN_HUMAN	PARN	physical	28514442
JMJD6_HUMAN	JMJD6	physical	28514442
KLH42_HUMAN	KLHL42	physical	28514442
ANKH1_HUMAN	ANKHD1	physical	28514442
MK03_HUMAN	MAPK3	physical	28514442
BACH2_HUMAN	BACH2	physical	28514442
DPH1_HUMAN	DPH1	physical	28514442
IF122_HUMAN	IFT122	physical	27173435
WDR19_HUMAN	WDR19	physical	27173435
WDR35_HUMAN	WDR35	physical	27173435
TT21B_HUMAN	TTC21B	physical	27173435
FOXK2_HUMAN	FOXK2	physical	27173435
RALB_HUMAN	RALB	physical	27173435
IFT43_HUMAN	IFT43	physical	27173435
EXOC3_HUMAN	EXOC3	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.