IF140_HUMAN - dbPTM
IF140_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IF140_HUMAN
UniProt AC Q96RY7
Protein Name Intraflagellar transport protein 140 homolog
Gene Name IFT140
Organism Homo sapiens (Human).
Sequence Length 1462
Subcellular Localization Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium .
Protein Description Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance. [PubMed: 22503633 May play a role in ciliary assembly. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity]
Protein Sequence MALYYDHQIEAPDAAGSPSFISWHPVHPFLAVAYISTTSTGSVDIYLEQGECVPDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQGTPLLKHEYGKHLTHCIFRLPPPGEDLVQLAKAAVSGDEKALDMFNWKKSSSGSLLKMGSHEGLLFFVSLMDGTVHYVDEKGKTTQVVSADSTIQMLFYMEKREALVVVTENLRLSLYTVPPEGKAEEVMKVKLSGKTGRRADIALIEGSLLVMAVGEAALRFWDIERGENYILSPDEKFGFEKGENMNCVCYCKVKGLLAAGTDRGRVAMWRKVPDFLGSPGAEGKDRWALQTPTELQGNITQIQWGSRKNLLAVNSVISVAILSERAMSSHFHQQVAAMQVSPSLLNVCFLSTGVAHSLRTDMHISGVFATKDAVAVWNGRQVAIFELSGAAIRSAGTFLCETPVLAMHEENVYTVESNRVQVRTWQGTVKQLLLFSETEGNPCFLDICGNFLVVGTDLAHFKSFDLSRREAKAHCSCRSLAELVPGVGGIASLRCSSSGSTISILPSKADNSPDSKICFYDVEMDTVTVFDFKTGQIDRRETLSFNEQETNKSHLFVDEGLKNYVPVNHFWDQSEPRLFVCEAVQETPRSQPQSANGQPQDGRAGPAADVLILSFFISEEHGFLLHESFPRPATSHSLLGMEVPYYYFTRKPEEADREDEVEPGCHHIPQMVSRRPLRDFVGLEDCDKATRDAMLHFSFFVTIGDMDEAFKSIKLIKSEAVWENMARMCVKTQRLDVAKVCLGNMGHARGARALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHDLLNKFYQAAGRWQEALQVAEHHDRVHLRSTYHRYAGHLEASADCSRALSYYEKSDTHRFEVPRMLSEDLPSLELYVNKMKDKTLWRWWAQYLESQGEMDAALHYYELARDHFSLVRIHCFQGNVQKAAQIANETGNLAASYHLARQYESQEEVGQAVHFYTRAQAFKNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEKGVQMDRAVMLYHKAGHFSKALELAFATQQFVALQLIAEDLDETSDPALLARCSDFFIEHSQYERAVELLLAARKYQEALQLCLGQNMSITEEMAEKMTVAKDSSDLPEESRRELLEQIADCCMRQGSYHLATKKYTQAGNKLKAMRALLKSGDTEKITFFASVSRQKEIYIMAANYLQSLDWRKEPEIMKNIIGFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLAKAKAKSPLDQETRLAQLQSRMALVKRFIQARRTYTEDPKESIKQCELLLEEPDLDSTIRIGDVYGFLVEHYVRKEEYQTAYRFLEEMRRRLPLANMSYYVSPQAVDAVHRGLGLPLPRTVPEQVRHNSMEDARELDEEVVEEADDDP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39UbiquitinationVAYISTTSTGSVDIY
EEEEECCCCCEEEEE		30.7522817900
41UbiquitinationYISTTSTGSVDIYLE
EEECCCCCEEEEEEE		25.9922817900
88UbiquitinationETGEVTVFNKQDKEQ
CCCEEEEEECCCCCC		7.4521890473
97PhosphorylationKQDKEQHTMPLTHTA
CCCCCCCCCCCEEEC		21.8525072903
101PhosphorylationEQHTMPLTHTADITV
CCCCCCCEEECEEEE		16.0025072903
103PhosphorylationHTMPLTHTADITVLR
CCCCCEEECEEEEEE		22.3125072903
107PhosphorylationLTHTADITVLRWSPS
CEEECEEEEEEECCC		17.6525072903
141PhosphorylationQRGRVQGTPLLKHEY
CCCCCCCCCEEECCC		8.1524719451
145UbiquitinationVQGTPLLKHEYGKHL
CCCCCEEECCCCCCE		41.91-
150UbiquitinationLLKHEYGKHLTHCIF
EEECCCCCCEEEEEE		34.2429967540
162UbiquitinationCIFRLPPPGEDLVQL
EEECCCCCCHHHHHH		57.7922817900
164UbiquitinationFRLPPPGEDLVQLAK
ECCCCCCHHHHHHHH		54.6822817900
166UbiquitinationLPPPGEDLVQLAKAA
CCCCCHHHHHHHHHH		1.9922817900
171UbiquitinationEDLVQLAKAAVSGDE
HHHHHHHHHHHCCCH		45.5321906983
179UbiquitinationAAVSGDEKALDMFNW
HHHCCCHHHHHHHCC		60.0129967540
187UbiquitinationALDMFNWKKSSSGSL
HHHHHCCCCCCCCCC		43.8329967540
188UbiquitinationLDMFNWKKSSSGSLL
HHHHCCCCCCCCCCE		47.3829967540
189PhosphorylationDMFNWKKSSSGSLLK
HHHCCCCCCCCCCEE		26.4723312004
190PhosphorylationMFNWKKSSSGSLLKM
HHCCCCCCCCCCEEE		47.8222985185
191PhosphorylationFNWKKSSSGSLLKMG
HCCCCCCCCCCEEEC		39.2223312004
191UbiquitinationFNWKKSSSGSLLKMG
HCCCCCCCCCCEEEC		39.2222817900
193PhosphorylationWKKSSSGSLLKMGSH
CCCCCCCCCEEECCC		32.2624719451
194UbiquitinationKKSSSGSLLKMGSHE
CCCCCCCCEEECCCC		6.4222817900
199PhosphorylationGSLLKMGSHEGLLFF
CCCEEECCCCCEEEE		18.18-
208PhosphorylationEGLLFFVSLMDGTVH
CCEEEEEEECCCEEE		16.9019835603
213PhosphorylationFVSLMDGTVHYVDEK
EEEECCCEEEEECCC		10.3919835603
216PhosphorylationLMDGTVHYVDEKGKT
ECCCEEEEECCCCCE		12.7819835603
251UbiquitinationALVVVTENLRLSLYT
EEEEEECCEEEEEEE		22.5422505724
270UbiquitinationGKAEEVMKVKLSGKT
CCHHHEEEEEECCCC		41.20-
272UbiquitinationAEEVMKVKLSGKTGR
HHHEEEEEECCCCCC		31.2721890473
274PhosphorylationEVMKVKLSGKTGRRA
HEEEEEECCCCCCCC		32.3129391485
288UbiquitinationADIALIEGSLLVMAV
CCEEEEECCHHHHHH		19.3222817900
314PhosphorylationRGENYILSPDEKFGF
CCCCEEECCCHHCCC		22.2821815630
318UbiquitinationYILSPDEKFGFEKGE
EEECCCHHCCCCCCC		59.1622817900
319UbiquitinationILSPDEKFGFEKGEN
EECCCHHCCCCCCCC		14.7722817900
323UbiquitinationDEKFGFEKGENMNCV
CHHCCCCCCCCCCEE		70.0822817900
336UbiquitinationCVCYCKVKGLLAAGT
EEEEEEECCCEECCC		29.36-
346UbiquitinationLAAGTDRGRVAMWRK
EECCCCCCCEEECEE		31.0922817900
348UbiquitinationAGTDRGRVAMWRKVP
CCCCCCCEEECEECC		4.8222817900
350UbiquitinationTDRGRVAMWRKVPDF
CCCCCEEECEECCCC		3.0422817900
353UbiquitinationGRVAMWRKVPDFLGS
CCEEECEECCCCCCC		42.4829967540
360PhosphorylationKVPDFLGSPGAEGKD
ECCCCCCCCCCCCCC		23.4729255136
366UbiquitinationGSPGAEGKDRWALQT
CCCCCCCCCCEEEEC		35.3121906983
384UbiquitinationLQGNITQIQWGSRKN
HCCCEEEEEECCCCC		2.5222817900
388PhosphorylationITQIQWGSRKNLLAV
EEEEEECCCCCHHHH		36.80-
389UbiquitinationTQIQWGSRKNLLAVN
EEEEECCCCCHHHHH		28.1322817900
405PhosphorylationVISVAILSERAMSSH
HHHHHHHCHHHHHCC		20.94-
435UbiquitinationNVCFLSTGVAHSLRT
HHHHHHCCCHHHHCC		15.9622505724
471UbiquitinationVAIFELSGAAIRSAG
EEEEEECCHHHHCCC		31.4822817900
472UbiquitinationAIFELSGAAIRSAGT
EEEEECCHHHHCCCE		9.0622817900
474UbiquitinationFELSGAAIRSAGTFL
EEECCHHHHCCCEEE		3.3822817900
552UbiquitinationSFDLSRREAKAHCSC
HCCCCHHHHHHHHCH		54.1121890473
558PhosphorylationREAKAHCSCRSLAEL
HHHHHHHCHHHHHHH		11.6021406692
561PhosphorylationKAHCSCRSLAELVPG
HHHHCHHHHHHHCCC		35.9421406692
562UbiquitinationAHCSCRSLAELVPGV
HHHCHHHHHHHCCCC		1.9122817900
568UbiquitinationSLAELVPGVGGIASL
HHHHHCCCCCEEEEE		24.1922817900
573UbiquitinationVPGVGGIASLRCSSS
CCCCCEEEEEEECCC		13.0422817900
574PhosphorylationPGVGGIASLRCSSSG
CCCCEEEEEEECCCC		17.9021406692
578PhosphorylationGIASLRCSSSGSTIS
EEEEEEECCCCCEEE		22.5421406692
579PhosphorylationIASLRCSSSGSTISI
EEEEEECCCCCEEEE		42.2021406692
580PhosphorylationASLRCSSSGSTISIL
EEEEECCCCCEEEEC		22.0721406692
582PhosphorylationLRCSSSGSTISILPS
EEECCCCCEEEECCC		25.2321406692
583PhosphorylationRCSSSGSTISILPSK
EECCCCCEEEECCCC		23.4421406692
585PhosphorylationSSSGSTISILPSKAD
CCCCCEEEECCCCCC		20.4021406692
589PhosphorylationSTISILPSKADNSPD
CEEEECCCCCCCCCC		36.7124719451
590UbiquitinationTISILPSKADNSPDS
EEEECCCCCCCCCCC		58.79-
602PhosphorylationPDSKICFYDVEMDTV
CCCCEEEEEEECCEE		18.05-
624PhosphorylationGQIDRRETLSFNEQE
CCCCEECEECCCCCC		26.3728555341
626UbiquitinationIDRRETLSFNEQETN
CCEECEECCCCCCCC		33.1822817900
628UbiquitinationRRETLSFNEQETNKS
EECEECCCCCCCCCC		46.8222817900
630UbiquitinationETLSFNEQETNKSHL
CEECCCCCCCCCCCE		65.0122817900
634UbiquitinationFNEQETNKSHLFVDE
CCCCCCCCCCEEECH		46.82-
635PhosphorylationNEQETNKSHLFVDEG
CCCCCCCCCEEECHH		27.7428555341
644UbiquitinationLFVDEGLKNYVPVNH
EEECHHHHCCCCCCC		58.0321906983
646PhosphorylationVDEGLKNYVPVNHFW
ECHHHHCCCCCCCCC		12.4427642862
714UbiquitinationLHESFPRPATSHSLL
CCCCCCCCCCCCHHC		39.8822817900
715UbiquitinationHESFPRPATSHSLLG
CCCCCCCCCCCHHCC		24.0222505724
716PhosphorylationESFPRPATSHSLLGM
CCCCCCCCCCHHCCC		29.6526074081
717PhosphorylationSFPRPATSHSLLGME
CCCCCCCCCHHCCCC		17.1226074081
717UbiquitinationSFPRPATSHSLLGME
CCCCCCCCCHHCCCC		17.1222817900
719PhosphorylationPRPATSHSLLGMEVP
CCCCCCCHHCCCCCC		25.6726074081
727PhosphorylationLLGMEVPYYYFTRKP
HCCCCCCEEEEECCH		18.9026074081
728PhosphorylationLGMEVPYYYFTRKPE
CCCCCCEEEEECCHH		5.9926074081
733UbiquitinationPYYYFTRKPEEADRE
CEEEEECCHHHCCCC		54.44-
752UbiquitinationPGCHHIPQMVSRRPL
CCCCCHHHHHCCCCH		44.2822817900
770UbiquitinationVGLEDCDKATRDAML
CCHHHCCHHHHHHHH		58.97-
795UbiquitinationMDEAFKSIKLIKSEA
HHHHHHHCHHHCCHH		4.3121890473
796UbiquitinationDEAFKSIKLIKSEAV
HHHHHHCHHHCCHHH		51.7722817900
799UbiquitinationFKSIKLIKSEAVWEN
HHHCHHHCCHHHHHH		53.3221906983
813UbiquitinationNMARMCVKTQRLDVA
HHHHHHHHHCCCCHH		33.7329967540
821UbiquitinationTQRLDVAKVCLGNMG
HCCCCHHHHHHCCCH		33.0729967540
848UbiquitinationQEPELEARVAVLATQ
HCHHHHHHHHHHHHH		13.9322817900
853UbiquitinationEARVAVLATQLGMLE
HHHHHHHHHHHCCHH		6.1622817900
869UbiquitinationAEQLYRKCKRHDLLN
HHHHHHHHHHHHHHH		3.2822817900
871UbiquitinationQLYRKCKRHDLLNKF
HHHHHHHHHHHHHHH		37.7122817900
873UbiquitinationYRKCKRHDLLNKFYQ
HHHHHHHHHHHHHHH		57.8122817900
877UbiquitinationKRHDLLNKFYQAAGR
HHHHHHHHHHHHHHH		45.4721890473
877UbiquitinationKRHDLLNKFYQAAGR
HHHHHHHHHHHHHHH		45.4721906983
877UbiquitinationKRHDLLNKFYQAAGR
HHHHHHHHHHHHHHH		45.4721890473
922PhosphorylationADCSRALSYYEKSDT
CCHHHHHHHHHCCCC		25.3727251275
926UbiquitinationRALSYYEKSDTHRFE
HHHHHHHCCCCCCEE		37.1929901268
951AcetylationSLELYVNKMKDKTLW
CCHHHHHHCCHHHHH		36.9690895
951UbiquitinationSLELYVNKMKDKTLW
CCHHHHHHCCHHHHH		36.9622817900
953UbiquitinationELYVNKMKDKTLWRW
HHHHHHCCHHHHHHH		58.6522817900
955UbiquitinationYVNKMKDKTLWRWWA
HHHHCCHHHHHHHHH		39.7422817900
958UbiquitinationKMKDKTLWRWWAQYL
HCCHHHHHHHHHHHH		10.0922505724
986PhosphorylationELARDHFSLVRIHCF
HHHHHHCCEEEEEEE		23.6424719451
995UbiquitinationVRIHCFQGNVQKAAQ
EEEEEECCCHHHHHH		18.9422817900
1013PhosphorylationETGNLAASYHLARQY
HHCCHHHHHHHHHHC		13.8922210691
1014PhosphorylationTGNLAASYHLARQYE
HCCHHHHHHHHHHCC		8.9822210691
1040UbiquitinationYTRAQAFKNAIRLCK
HHHHHHHHHHHHHHH		48.7822505724
1077UbiquitinationAARYYEEKGVQMDRA
HHHHHHHHCCCHHHH		53.0621906983
1090UbiquitinationRAVMLYHKAGHFSKA
HHHHHHHHHCCHHHH		42.3729967540
1091UbiquitinationAVMLYHKAGHFSKAL
HHHHHHHHCCHHHHH		11.9022817900
1096UbiquitinationHKAGHFSKALELAFA
HHHCCHHHHHHHHHH		56.9222817900
1121PhosphorylationAEDLDETSDPALLAR
HHCCCCCCCHHHHHH		39.2822468782
1139PhosphorylationFFIEHSQYERAVELL
HHHCCCHHHHHHHHH		15.4822468782
1173UbiquitinationITEEMAEKMTVAKDS
CCHHHHHHCCCCCCC		30.2722817900
1178UbiquitinationAEKMTVAKDSSDLPE
HHHCCCCCCCCCCCH		54.5322817900
1211UbiquitinationSYHLATKKYTQAGNK
CHHHCCHHCCCHHHH		49.5329967540
1212PhosphorylationYHLATKKYTQAGNKL
HHHCCHHCCCHHHHH		12.9728111955
1213PhosphorylationHLATKKYTQAGNKLK
HHCCHHCCCHHHHHH		22.3328111955
1218AcetylationKYTQAGNKLKAMRAL
HCCCHHHHHHHHHHH		50.9125953088
1218UbiquitinationKYTQAGNKLKAMRAL
HCCCHHHHHHHHHHH		50.9129967540
1228PhosphorylationAMRALLKSGDTEKIT
HHHHHHHCCCCCEEE		41.7029083192
1231PhosphorylationALLKSGDTEKITFFA
HHHHCCCCCEEEEEE		42.5829083192
1235PhosphorylationSGDTEKITFFASVSR
CCCCCEEEEEEECCC		24.6229083192
1239PhosphorylationEKITFFASVSRQKEI
CEEEEEEECCCCCCE		18.5722496350
1312UbiquitinationGALTEAYKCLAKAKA
CHHHHHHHHHHHHHC		29.8029967540
1320UbiquitinationCLAKAKAKSPLDQET
HHHHHHCCCCCCHHH		52.4829967540
1334PhosphorylationTRLAQLQSRMALVKR
HHHHHHHHHHHHHHH		32.39-
1358UbiquitinationEDPKESIKQCELLLE
CCHHHHHHHHHHHHC		59.1729967540
1434PhosphorylationLGLPLPRTVPEQVRH
CCCCCCCCCCHHHHC		38.1724719451
1443PhosphorylationPEQVRHNSMEDAREL
CHHHHCCCHHHHHHH		19.8822617229
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IF140_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IF140_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IF140_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WDR19_HUMANWDR19physical
27173435
IFT43_HUMANIFT43physical
27173435
TULP3_HUMANTULP3physical
27173435
WDR35_HUMANWDR35physical
27173435
IF122_HUMANIFT122physical
27173435
TT21B_HUMANTTC21Bphysical
27173435
NTPCR_HUMANNTPCRphysical
27173435
ACSL3_HUMANACSL3physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
266920Short-rib thoracic dysplasia 9 with or without polydactyly (SRTD9)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IF140_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND MASSSPECTROMETRY.

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