WDR35_HUMAN - dbPTM
WDR35_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR35_HUMAN
UniProt AC Q9P2L0
Protein Name WD repeat-containing protein 35
Gene Name WDR35
Organism Homo sapiens (Human).
Sequence Length 1181
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
Protein Description Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis..
Protein Sequence MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLKVPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MFFYLSKKISI
----CCEEEECCCCC		18.5224719451
6Phosphorylation--MFFYLSKKISIPN
--CCEEEECCCCCCC		22.1124719451
8UbiquitinationMFFYLSKKISIPNNV
CCEEEECCCCCCCCC		38.0129967540
10PhosphorylationFYLSKKISIPNNVKL
EEEECCCCCCCCCEE		40.6524719451
24UbiquitinationLQCVSWNKEQGFIAC
EEEEECCCCCCEEEE		45.1929967540
39UbiquitinationGGEDGLLKVLKLETQ
ECCCCCEEEEEEEEC		51.0329967540
42UbiquitinationDGLLKVLKLETQTDD
CCCEEEEEEEECCCC		47.4629967540
51UbiquitinationETQTDDAKLRGLAAP
EECCCCHHHCCCCCC		45.7921906983
51 (in isoform 1)Ubiquitination-45.7921890473
51 (in isoform 2)Ubiquitination-45.7921890473
63UbiquitinationAAPSNLSMNQTLEGH
CCCCCCCCCCCCCCC		4.9321963094
89PhosphorylationQYQKLTTSDENGLII
HHCCCCCCCCCCEEE		37.3822210691
152UbiquitinationDGNRIWGKDLKGIQL
CCCEECCCCCCCCEE		44.91-
155UbiquitinationRIWGKDLKGIQLSHV
EECCCCCCCCEEEEE		65.1921963094
245UbiquitinationIMRHENDQNPVLIDT
EEECCCCCCCEEEEC		68.6522817900
249UbiquitinationENDQNPVLIDTGMYV
CCCCCCEEEECCCEE		2.8621963094
274UbiquitinationVLAVAGFQKAAMQDK
HHHHHHCHHHHHCCC		33.2921963094
281UbiquitinationQKAAMQDKDVNIVQF
HHHHHCCCCCCEEEE		46.84-
289PhosphorylationDVNIVQFYTPFGEHL
CCCEEEEECCCHHHC		9.0828348404
290PhosphorylationVNIVQFYTPFGEHLG
CCEEEEECCCHHHCC		17.2728348404
298PhosphorylationPFGEHLGTLKVPGKE
CCHHHCCEEECCCCE		29.7528348404
300UbiquitinationGEHLGTLKVPGKEIS
HHHCCEEECCCCEEE		46.34-
304UbiquitinationGTLKVPGKEISALSW
CEEECCCCEEEEEEE		45.8929967540
308UbiquitinationVPGKEISALSWEGGG
CCCCEEEEEEECCCC		15.9821963094
341UbiquitinationNYKWGYCSNTVVYAY
CCCCCCCCCEEEEEE		27.3521890473
353UbiquitinationYAYTRPDRPEYCVVF
EEEECCCCCCEEEEE		28.7421963094
380UbiquitinationVKGLISITTCGDFCI
HCCCEEEEECCCEEE		14.8321890473
446UbiquitinationTHVIAASKEAFYTWQ
CEEEEECHHHHHHHH		48.62-
459UbiquitinationWQYRVAKKLTALEIN
HHHHHHHHCHHHHHH		41.13-
480PhosphorylationKEGRERIYHVDDTPS
CCCCCCEEECCCCCC		11.3027732954
485PhosphorylationRIYHVDDTPSGSMDG
CEEECCCCCCCCCCC		18.1925954137
487PhosphorylationYHVDDTPSGSMDGVL
EECCCCCCCCCCCCC		45.6624719451
487UbiquitinationYHVDDTPSGSMDGVL
EECCCCCCCCCCCCC		45.6621963094
489PhosphorylationVDDTPSGSMDGVLDY
CCCCCCCCCCCCCCC		20.3125954137
496PhosphorylationSMDGVLDYSKTIQGT
CCCCCCCCCCCCCCC		14.1227642862
498UbiquitinationDGVLDYSKTIQGTRD
CCCCCCCCCCCCCCC		43.3421963094
513UbiquitinationPICAITASDKILIVG
CEEEEECCCEEEEEE		30.6821963094
517UbiquitinationITASDKILIVGRESG
EECCCEEEEEECCCC		2.9822817900
539UbiquitinationPNVGLIQKYSLNCRA
CCCCEEEEEECCCEE		29.79-
547PhosphorylationYSLNCRAYQLSLNCN
EECCCEEEEEEECCC		7.2229978859
550PhosphorylationNCRAYQLSLNCNSSR
CCEEEEEEECCCCCC		11.3029978859
555PhosphorylationQLSLNCNSSRLAIID
EEEECCCCCCEEEEE		21.0229978859
556PhosphorylationLSLNCNSSRLAIIDI
EEECCCCCCEEEEEE		19.8129978859
557UbiquitinationSLNCNSSRLAIIDIS
EECCCCCCEEEEEEC		28.1422817900
559UbiquitinationNCNSSRLAIIDISGV
CCCCCCEEEEEECCC		8.7922817900
561UbiquitinationNSSRLAIIDISGVLT
CCCCEEEEEECCCEE		2.9821963094
564PhosphorylationRLAIIDISGVLTFFD
CEEEEEECCCEEEEE		21.07-
568PhosphorylationIDISGVLTFFDLDAR
EEECCCEEEEEECCC		21.61-
579UbiquitinationLDARVTDSTGQQVVG
ECCCEECCCCCHHHH		25.6821963094
579 (in isoform 2)Ubiquitination-25.6821890473
590UbiquitinationQVVGELLKLERRDVW
HHHHHHHHEECCCCC		62.0121906983
590 (in isoform 1)Ubiquitination-62.0121890473
642UbiquitinationICNFEDLEIKSVLLD
ECCCHHCCEEHHHHH		61.7729967540
653UbiquitinationVLLDEILKDPEHPNK
HHHHHHHHCCCCCCC		76.5229967540
667UbiquitinationKDYLINFEIRSLRDS
CCCEEEEEEEEHHHH		32.7621963094
669UbiquitinationYLINFEIRSLRDSRA
CEEEEEEEEHHHHHH		23.5733845483
669 (in isoform 2)Ubiquitination-23.5721890473
673UbiquitinationFEIRSLRDSRALIEK
EEEEEHHHHHHHHHH		48.0121963094
673 (in isoform 2)Ubiquitination-48.0121890473
680UbiquitinationDSRALIEKVGIKDAS
HHHHHHHHHCCCCHH		38.4721906983
680 (in isoform 1)Ubiquitination-38.4721890473
684UbiquitinationLIEKVGIKDASQFIE
HHHHHCCCCHHHHHC		41.1121906983
684 (in isoform 1)Ubiquitination-41.1121890473
698UbiquitinationEDNPHPRLWRLLAEA
CCCCCHHHHHHHHHH		3.5321963094
709UbiquitinationLAEAALQKLDLYTAE
HHHHHHHHCCCEEHH		44.8321963094
712UbiquitinationAALQKLDLYTAEQAF
HHHHHCCCEEHHHHH		6.2429967540
718UbiquitinationDLYTAEQAFVRCKDY
CCEEHHHHHHHCCCC		9.0833845483
723UbiquitinationEQAFVRCKDYQGIKF
HHHHHHCCCCCHHHH		49.2429967540
725PhosphorylationAFVRCKDYQGIKFVK
HHHHCCCCCHHHHHH		8.3019664994
729UbiquitinationCKDYQGIKFVKRLGK
CCCCCHHHHHHHHHH		51.4333845483
732UbiquitinationYQGIKFVKRLGKLLS
CCHHHHHHHHHHHHH		45.0721963094
736UbiquitinationKFVKRLGKLLSESMK
HHHHHHHHHHHHHHH		51.34-
743UbiquitinationKLLSESMKQAEVVGY
HHHHHHHHHHCHHEE		56.4821963094
765UbiquitinationERTYLEMDRRDLAIG
HHHHHHCCHHHHHHH		32.8421890473
765UbiquitinationERTYLEMDRRDLAIG
HHHHHHCCHHHHHHH		32.8421890473
765 (in isoform 2)Ubiquitination-32.8421890473
776UbiquitinationLAIGLRLKLGDWFRV
HHHHHEEEHHHHHHH		43.9521963094
776UbiquitinationLAIGLRLKLGDWFRV
HHHHHEEEHHHHHHH		43.9521890473
776 (in isoform 1)Ubiquitination-43.9521890473
777UbiquitinationAIGLRLKLGDWFRVL
HHHHEEEHHHHHHHH		9.9721963094
788UbiquitinationFRVLQLLKTGSGDAD
HHHHHHHHHCCCCCC		60.4721963094
804UbiquitinationSLLEQANNAIGDYFA
HHHHHHHHHHHHHHH		35.6321890473
804UbiquitinationSLLEQANNAIGDYFA
HHHHHHHHHHHHHHH		35.6321890473
804 (in isoform 2)Ubiquitination-35.6321890473
815UbiquitinationDYFADRQKWLNAVQY
HHHHHHHHHHHHHHH		55.3221890473
815UbiquitinationDYFADRQKWLNAVQY
HHHHHHHHHHHHHHH		55.3221890473
815 (in isoform 1)Ubiquitination-55.3221890473
881UbiquitinationQAVTAFLKCSQPKAA
HHHHHHHHCCCCCHH		25.95-
889UbiquitinationCSQPKAAVDTCVHLN
CCCCCHHHHHHHHHH		8.1729967540
895UbiquitinationAVDTCVHLNQWNKAV
HHHHHHHHHHHHHHH		2.2529967540
900UbiquitinationVHLNQWNKAVELAKN
HHHHHHHHHHHHHHH		51.3429967540
906UbiquitinationNKAVELAKNHSMKEI
HHHHHHHHHCCHHHH		68.7529967540
911UbiquitinationLAKNHSMKEIGSLLA
HHHHCCHHHHHHHHH		49.55-
915PhosphorylationHSMKEIGSLLARYAS
CCHHHHHHHHHHHHH		26.3523403867
916UbiquitinationSMKEIGSLLARYASH
CHHHHHHHHHHHHHH		3.5029967540
918UbiquitinationKEIGSLLARYASHLL
HHHHHHHHHHHHHHH		14.0229967540
927UbiquitinationYASHLLEKNKTLDAI
HHHHHHHHCCCCHHH		64.8129967540
929UbiquitinationSHLLEKNKTLDAIEL
HHHHHHCCCCHHHHH		62.6329967540
930PhosphorylationHLLEKNKTLDAIELY
HHHHHCCCCHHHHHH		38.98-
937UbiquitinationTLDAIELYRKANYFF
CCHHHHHHHHHCHHH		9.4021963094
941UbiquitinationIELYRKANYFFDAAK
HHHHHHHCHHHHHHH		36.8622817900
948UbiquitinationNYFFDAAKLMFKIAD
CHHHHHHHHHHHHCC		42.0521963094
952UbiquitinationDAAKLMFKIADEEAK
HHHHHHHHHCCHHHH		24.0222817900
962PhosphorylationDEEAKKGSKPLRVKK
CHHHHCCCCCCHHHH		39.7224719451
971PhosphorylationPLRVKKLYVLSALLI
CCHHHHHHHHHHHHH		14.2823898821
974PhosphorylationVKKLYVLSALLIEQY
HHHHHHHHHHHHHHH		13.5623898821
981UbiquitinationSALLIEQYHEQMKNA
HHHHHHHHHHHHHHH		8.4422817900
981PhosphorylationSALLIEQYHEQMKNA
HHHHHHHHHHHHHHH		8.4423898821
983UbiquitinationLLIEQYHEQMKNAQR
HHHHHHHHHHHHHHC		47.6522817900
985UbiquitinationIEQYHEQMKNAQRGK
HHHHHHHHHHHHCCC		3.0921963094
992UbiquitinationMKNAQRGKVKGKSSE
HHHHHCCCCCCCCHH		42.8522817900
994UbiquitinationNAQRGKVKGKSSEAT
HHHCCCCCCCCHHHH		65.2022817900
996UbiquitinationQRGKVKGKSSEATSA
HCCCCCCCCHHHHHH		45.1221963094
1081UbiquitinationCACASRAFGTCSKAF
HHHHHHHHCHHCHHH		8.9429967540
1086UbiquitinationRAFGTCSKAFIKLKS
HHHCHHCHHHHHHHC		49.84-
1091UbiquitinationCSKAFIKLKSLETLS
HCHHHHHHHCHHCCC		3.7821963094
1091 (in isoform 2)Ubiquitination-3.7821890473
1092UbiquitinationSKAFIKLKSLETLSS
CHHHHHHHCHHCCCH		48.2529967540
1102UbiquitinationETLSSEQKQQYEDLA
HCCCHHHHHHHHHHH		35.0021963094
1102 (in isoform 1)Ubiquitination-35.0021890473
1104UbiquitinationLSSEQKQQYEDLALE
CCHHHHHHHHHHHHH		51.0921963094
1108UbiquitinationQKQQYEDLALEIFTK
HHHHHHHHHHHHHHH		3.8122817900
1115UbiquitinationLALEIFTKHTSKDNR
HHHHHHHHCCCCCCC		33.8521963094
1119UbiquitinationIFTKHTSKDNRKPEL
HHHHCCCCCCCCCHH		61.2422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR35_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR35_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR35_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IFT43_HUMANIFT43physical
27173435
TT21B_HUMANTTC21Bphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613610Cranioectodermal dysplasia 2 (CED2)
614091Short-rib thoracic dysplasia 7 with or without polydactyly (SRTD7)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR35_HUMAN

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Related Literatures of Post-Translational Modification

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