DCA16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCA16_HUMAN
• UniProt AC: Q9NXF7
• Protein Name: DDB1- and CUL4-associated factor 16
• Gene Name: DCAF16
• Organism: Homo sapiens (Human).
• Sequence Length: 216
• Protein Description: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
• Protein Sequence: MGPRNPSPDHLSESESEEEENISYLNESSGEEWDSSEEEDSMVPNLSPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDPSTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLTSPSRLSRDHATLNGALQFATKQLSRTLSRATPIPEYLKQIPNSCVSGCCCGWLTKTVKETTRTEPINTTYSYTDFQKAVNKLLTASL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Acetylation	WQVKCLLKYSTTWKP HHHHHHHHCCCCCCC	24.98	19608861
79	Ubiquitination	NSWLYHAKLLDPSTP CCEEEEEECCCCCCC	35.95	-
79	Ubiquitination	NSWLYHAKLLDPSTP CCEEEEEECCCCCCC	35.95	23000965
85	Phosphorylation	AKLLDPSTPVHILRE EECCCCCCCHHHHHH	34.42	-
129	Phosphorylation	PPFQKPLTSPSRLSR CCCCCCCCCHHHHCC	47.31	27067055
130	Phosphorylation	PFQKPLTSPSRLSRD CCCCCCCCHHHHCCC	28.67	27067055
135	Phosphorylation	LTSPSRLSRDHATLN CCCHHHHCCCCHHHH	34.25	26657352
150	Ubiquitination	GALQFATKQLSRTLS HHHHHHHHHHHHHHH	45.90	21890473
150	Ubiquitination	GALQFATKQLSRTLS HHHHHHHHHHHHHHH	45.90	22817900
165	Phosphorylation	RATPIPEYLKQIPNS HCCCCHHHHHHCCCC	17.53	27642862
167	Ubiquitination	TPIPEYLKQIPNSCV CCCHHHHHHCCCCCH	45.33	22505724
187	Ubiquitination	GWLTKTVKETTRTEP HHHHHCCCCCCCCCC	55.35	29967540
192	Phosphorylation	TVKETTRTEPINTTY CCCCCCCCCCCCCCE	43.98	24043423
197	Phosphorylation	TRTEPINTTYSYTDF CCCCCCCCCEEHHHH	28.03	24043423
198	Phosphorylation	RTEPINTTYSYTDFQ CCCCCCCCEEHHHHH	13.14	24043423
199	Phosphorylation	TEPINTTYSYTDFQK CCCCCCCEEHHHHHH	9.53	27642862
200	Phosphorylation	EPINTTYSYTDFQKA CCCCCCEEHHHHHHH	21.33	24043423
201	Phosphorylation	PINTTYSYTDFQKAV CCCCCEEHHHHHHHH	10.42	24043423
202	Phosphorylation	INTTYSYTDFQKAVN CCCCEEHHHHHHHHH	25.13	24043423
206	Ubiquitination	YSYTDFQKAVNKLLT EEHHHHHHHHHHHHH	55.05	21906983
210	Ubiquitination	DFQKAVNKLLTASL- HHHHHHHHHHHHCC-	37.97	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCA16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCA16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCA16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM1_HUMAN	PRMT1	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
DDB1_HUMAN	DDB1	physical	16949367
CUL4A_HUMAN	CUL4A	physical	16949367

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61, AND MASS SPECTROMETRY.
PubMed: 19608861