LCORL_HUMAN - dbPTM
LCORL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LCORL_HUMAN
UniProt AC Q8N3X6
Protein Name Ligand-dependent nuclear receptor corepressor-like protein
Gene Name LCORL
Organism Homo sapiens (Human).
Sequence Length 602
Subcellular Localization Nucleus .
Protein Description May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity)..
Protein Sequence MDKGRERMAAAAAAAAAAAAAAQCRSPRCAAERRGFRRELDSWRHRLMHCVGFESILEGLYGPRLRRDLSLFEDCEPEELTDWSMDEKCSFCNLQREAVSDCIPSLDSSQSTPTEELSSQGQSNTDKIECQAENYLNALFRKKDLPQNCDPNIPLVAQELMKKMIRQFAIEYISKSGKTQENRNGSIGPSIVCKSIQMNQAENSLQEEQEGPLDLTVNRMQEQNTQQGDGVLDLSTKKTSIKSEESSICDPSSENSVAGRLHRNREDYVERSAEFADGLLSKALKDIQSGALDINKAGILYGIPQKTLLLHLEALPAGKPASFKNKTRDFHDSYSYKDSKETCAVLQKVALWARAQAERTEKSKLNLLETSEIKFPTASTYLHQLTLQKMVTQFKEKNESLQYETSNPTVQLKIPQLRVSSVSKSQPDGSGLLDVMYQVSKTSSVLEGSALQKLKNILPKQNKIECSGPVTHSSVDSYFLHGDLSPLCLNSKNGTVDGTSENTEDGLDRKDSKQPRKKRGRYRQYDHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLEYKVKERSGTLKTPPKKKLRLPDTGLYNMTDSGTGSCKNSSKPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationAAAAQCRSPRCAAER
HHHHHCCCHHHHHHH		25.0728122231
108PhosphorylationDCIPSLDSSQSTPTE
HHCCCCCCCCCCCHH		35.25-
119PhosphorylationTPTEELSSQGQSNTD
CCHHHHHHCCCCCCC		51.45-
142UbiquitinationYLNALFRKKDLPQNC
HHHHHHHCCCCCCCC		43.22-
143UbiquitinationLNALFRKKDLPQNCD
HHHHHHCCCCCCCCC		61.31-
172PhosphorylationIRQFAIEYISKSGKT
HHHHHHHHHHHCCCC		12.3719835603
175UbiquitinationFAIEYISKSGKTQEN
HHHHHHHHCCCCCCC		54.38-
204PhosphorylationQMNQAENSLQEEQEG
HHCHHHHHHHHHHCC		23.9626714015
235PhosphorylationGDGVLDLSTKKTSIK
CCCEEECCCCCCCCC		37.5424275569
236PhosphorylationDGVLDLSTKKTSIKS
CCEEECCCCCCCCCC		43.8024275569
237 (in isoform 3)Ubiquitination-51.1621906983
237 (in isoform 1)Ubiquitination-51.1621906983
237UbiquitinationGVLDLSTKKTSIKSE
CEEECCCCCCCCCCC		51.162190698
240PhosphorylationDLSTKKTSIKSEESS
ECCCCCCCCCCCCCC		36.5824275569
242SumoylationSTKKTSIKSEESSIC
CCCCCCCCCCCCCCC		52.1328112733
243PhosphorylationTKKTSIKSEESSICD
CCCCCCCCCCCCCCC		44.9524275569
246 (in isoform 3)Phosphorylation-22.4325954137
252 (in isoform 3)Phosphorylation-36.7125954137
265 (in isoform 3)Phosphorylation-37.8125954137
278 (in isoform 3)Phosphorylation-25.7025262027
281PhosphorylationEFADGLLSKALKDIQ
HHHHHHHHHHHHHHH		22.4124719451
282 (in isoform 3)Phosphorylation-58.6819664994
319AcetylationLEALPAGKPASFKNK
HHHCCCCCCCCCCCC		39.2526051181
319SumoylationLEALPAGKPASFKNK
HHHCCCCCCCCCCCC		39.2528112733
322PhosphorylationLPAGKPASFKNKTRD
CCCCCCCCCCCCCCC		45.3324719451
337UbiquitinationFHDSYSYKDSKETCA
CCCCCCCCCHHHHHH		49.97-
340SumoylationSYSYKDSKETCAVLQ
CCCCCCHHHHHHHHH		68.1528112733
364UbiquitinationAERTEKSKLNLLETS
HHHHHHHHCCHHHHC		53.08-
397SumoylationMVTQFKEKNESLQYE
HHHHHHHHCCCCCEE		67.6128112733
397UbiquitinationMVTQFKEKNESLQYE
HHHHHHHHCCCCCEE		67.61-
400PhosphorylationQFKEKNESLQYETSN
HHHHHCCCCCEECCC		30.1128555341
403PhosphorylationEKNESLQYETSNPTV
HHCCCCCEECCCCCE		26.8529978859
405PhosphorylationNESLQYETSNPTVQL
CCCCCEECCCCCEEE		28.9529978859
406PhosphorylationESLQYETSNPTVQLK
CCCCEECCCCCEEEE		28.9529978859
409PhosphorylationQYETSNPTVQLKIPQ
CEECCCCCEEEECCE		25.7429978859
413UbiquitinationSNPTVQLKIPQLRVS
CCCCEEEECCEEEEE		34.94-
423PhosphorylationQLRVSSVSKSQPDGS
EEEEEECCCCCCCCC		28.6523532336
430PhosphorylationSKSQPDGSGLLDVMY
CCCCCCCCCHHHHHH		33.3823532336
485PhosphorylationYFLHGDLSPLCLNSK
EECCCCCCCCEEECC		22.1425159151
556PhosphorylationGIYGVPHSTLEYKVK
CCCCCCCCCEEEEEH		28.72-
566PhosphorylationEYKVKERSGTLKTPP
EEEEHHCCCCCCCCC		36.9023312004
568PhosphorylationKVKERSGTLKTPPKK
EEHHCCCCCCCCCCC		26.7423312004
571PhosphorylationERSGTLKTPPKKKLR
HCCCCCCCCCCCCCC		48.1923312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LCORL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LCORL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LCORL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LCORL_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LCORL_HUMAN

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Related Literatures of Post-Translational Modification

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